Isabel Haro

Determining Marine Protected Area Zoning Under Multiple Objectives: Do Marine Managers’ Priorities Align?

Sean Pascoe, Louisa Coglan, Ella Dewilde, Toni Cannard et autres

Globally, marine protected areas (MPAs) have been designated with the aim of protecting marine biodiversity, primarily from extractive activities such as fishing. Most MPAs also include a range of zones with different fishing or other activities allowed in each, generally referred to …

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Abatacept versus hydroxychloroquine for prevention of rheumatoid arthritis in individuals with palindromic rheumatism: a randomized open-label trial

Raimon Sanmarti, Carolina Pérez-García, Francisco J. de-Toro, Georgina Salvador et autres

per day) could reduce the frequency of RA development in individuals with palindromic rheumatism positive for rheumatoid factor and/or anticitrullinated protein antibody. The primary outcome was the development of persistent arthritis that fulfilled the 2010 RA classification criteria of the American College …

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Self‐Assembly of Anti‐Inflammatory Peptide Amphiphiles for Mucosal Health

María J. Gómara, Ignacio Pérez‐Pomeda, Ramón Pons, Paul Ziprin et autres

Broad spectrum anti‐inflammatory peptide amphiphiles (AIF‐PAs) have been developed as an innovative strategy for the treatment of chronic mucosal inflammation and the prevention of HIV transmission. Novel lipopeptides based on two linear sequences of anti‐inflammatory peptides were obtained by solid‐phase peptide chemistry. …

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Structural Study of a Peptide Epitope Bearing Multiple Post-Translational Modifications in Rheumatoid Arthritis

María J. Gómara, Cristina García-Moreno, Oriol Bárcenas, Raúl Castellanos‐Moreira et autres

Given the limited knowledge of the effect of post-translational modifications (PTMs) on protein structure, in this study we investigated whether introducing one-to-three RA-related PTMs into the α-fibrin (617-631) peptide influences the conformation and structure of the peptide antigen that could be responsible …

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OP0105 EFFECTS OF ABATACEPT VERSUS HYDROXYCHLOROQUINE ON THE PROGRESSION TO RHEUMATOID ARTHRITIS IN PALINDROMIC RHEUMATISM: A TWO-YEAR MULTICENTER RANDOMIZED CLINICAL TRIAL. THE PALABA STUDY

R. Sanmarti, C Perez-Garcia, F. J. De-Toro-Santos, Georgina Salvador Alarcon et autres

Background: Patients with palindromic rheumatism (PR), a form of intermittent arthritis/periarthritis, have a high risk of developing rheumatoid arthritis (RA), especially those with positive rheumatoid factor (RF) and/or anti-citrullinated protein antibodies (ACPA). Treatment of PR is empirical, with hydroxychloroquine being one of …

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Fisheries’ Economic Impacts from the Rezoning of the Multi-Use Moreton Bay Marine Park

Sean Pascoe, Louisa Coglan, Marjoleine M.H. Roos, Toni Cannard et autres

Marine protected areas (MPAs) have been implemented globally to protect marine habitats and enhance biodiversity, often displacing commercial and recreational fishing activities previously occurring in the area. While the ecological impacts of MPAs have been the subject of considerable attention, the economic …

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Novel Tissue-Specific Multifunctionalized Nanotechnological Platform Encapsulating Riluzole Against Motor Neuron Diseases

Gerard Esteruelas, Miren Ettcheto, Isabel Haro, Mireia Herrando‐Grabulosa et autres

Background: Motor neuron diseases are neurological disorders characterized by progressive degeneration of upper and/or lower motor neurons. Amyotrophic Lateral Sclerosis (ALS) is the most common form of motor neuron diseases, where patients suffer progressive paralysis, muscle atrophy and finally death. Despite ALS …

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A lipid hydrogel to transport and release an anti-HIV-1 peptide into vaginal mucosa

Noèlia Loza-Rodríguez, Aïna Millán‐Sánchez, Aleix Benítez, Ramón Pons et autres

A graphical representation of the development process of a lipidic hydrogel loaded with an anti-HIV peptide for pre-exposure prophylaxis: characterization, ex vivo mucosa permeation, and efficacy testing in vaginal mucosa.

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Anti-Modified Peptide Antibodies (AMPAs) in Rheumatoid Arthritis: Study of the Diagnostic Value of Citrullinated, Homocitrullinated, and Acetylated Fibrin/Filaggrin Chimeric Peptides

Isabel Haro, Raúl Castellanos‐Moreira, Raimón Sanmartí, María J. Gómara

Background/Objectives. The presence of anti-citrullinated peptide/protein antibodies (ACPAs), anti-carbamylated peptide/protein antibodies (anti-CarPs), and anti-acetylated peptide/protein antibodies (AAPAs), collectively termed as anti-modified peptide/protein antibodies (AMPAs), is a hallmark of rheumatoid arthritis. These autoantibodies play a crucial role in the complex autoimmune responses observed …

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Engineering PSMA-targeted nanoparticles co-encapsulating mitoxantrone and indocyanine green for precise combinatory therapy in prostate cancer

Sobia Khan, D. Mansoor Hussain, Amarachi Obinyima, Clara Pina-Coronado et autres

Prostate cancer is the 2nd most common cancer in men worldwide. Chemotherapeutic treatment of prostate cancer with mitoxantrone (MTX) has limited efficacy due to severe side effects in which cardiotoxicity and myelosuppression are the two major causes of its dose-limiting toxicity. This …

Novel Chimeric Peptides Based on the Enolase Peptide Antigen (CEP-1) Bearing Three Post-Translational Modifications (Citrullination, Homocitrullination and Acetylation) for Determining the Diagnosis and Severity of Rheumatoid Arthritis

María J. Gómara, Juan Camilo Sarmiento-Monroy, Raúl Castellanos‐Moreira, José A. Gómez‐Puerta et autres

With the aim of improving the uncertainties associated with the correct diagnosis of seronegative rheumatoid arthritis (RA) and identifying those at risk of developing interstitial lung disease (ILD), we have designed new peptide antigens bearing three post-translational modifications (PTMs) (citrulline, homocitrulline and …

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Neutrophilic Activity Biomarkers (Plasma Neutrophil Extracellular Traps and Calprotectin) in Established Patients with Rheumatoid Arthritis Receiving Biological or JAK Inhibitors: A Clinical and Ultrasonographic Study

Beatriz Frade‐Sosa, Andrés Ponce, Estíbaliz Ruiz‐Ortiz, Noemí de Moner et autres

INTRODUCTION: This study assesses the accuracy of neutrophil activation markers, including neutrophil extracellular traps (NETs) and calprotectin, as biomarkers of disease activity in patients with established rheumatoid arthritis (RA). We also analyse the relationship between NETs and various types of therapies as …

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