Zahra Reynolds

Coronary artery disease and neurocognitive performance among older adults in Uganda

Richard Migisha, Jolina Lombardi, Pauline Byakika‐Kibwika, Noeline Nakasujja et autres

Ouganda, us (code pays fourni par la source)

B‐Cell Depletion Relative to Tumor Necrosis Factor Inhibition Extends the Duration of Viral Shedding in COVID‐19 Among Autoimmune Disease Patients: A Matched Prospective Cohort Study

Liya S. Getachew, Xiaosong Wang, Naomi J. Patel, Zachary S. Wallace et autres

OBJECTIVE: To investigate SARS-CoV-2 viral shedding duration in autoimmune patients using B cell depleting (BCD) therapy or tumor necrosis factor inhibitors (TNFi) and immunocompetent comparators. METHODS: We conducted a matched cohort analysis among participants in POSITIVES, a prospective study enrolling outpatients with …

us (code pays fourni par la source)

Post-infection immune response in adults with COVID-19 with and without nirmatrelvir-ritonavir treatment and virologic rebound

Dibya Ghimire, Chloe M. Hasund, John Bianchi Colangeli, May Y. Liew et autres

Background: Nirmatrelvir-ritonavir (N-R) reduces morbidity and mortality from COVID-19 in high-risk individuals; however, N-R use has been associated with risk of SARS-CoV-2 virologic rebound. The mechanisms contributing to virologic rebound after N-R treatment are currently unknown. One plausible mechanism is that antiviral …

us (code pays fourni par la source)

Long-term trends in HIV-related stigma among older adults with and without HIV: a cohort study from Mbarara, Uganda

Chase Mandell, Janet Seeley, Samuel Maling, Noeline Nakasujja et autres

BACKGROUND AND OBJECTIVES: Perceived HIV stigma is a persistent challenge, contributing to reduced antiretroviral therapy adherence among people with HIV. Although perceived stigma declined with treatment rollout, it is unknown if that trend has continued, particularly among the growing population of older …

us, gb, Afrique du Sud, Ouganda, Zambie (code pays fourni par la source)

Prevalence and Correlates of Steatotic Liver Disease Among People With HIV in Uganda

Prossy Bibangambah, Moses Acan, Brian Ghoshhajra, Geoffrey Erem et autres

Abstract Background Liver disease is an important cause of morbidity and mortality among people with HIV (PWH). Steatotic liver disease (SLD) is a leading cause of liver disease among PWH in the Global North. However, there is a dearth of data on …

Ouganda, us, Afrique du Sud, tw (code pays fourni par la source)

Age-related disparities in viral suppression among older individuals living with HIV in rural Uganda

J. Tumwesigyire, Eliza Passell, Flavia Atwiine, Edna Tindimwebwa et autres

BACKGROUND: The number of people living with HIV (PLWH) in sub-Saharan Africa who are over 50 years old is increasing rapidly, and expected to triple by 2040. Yet, how older PLWH sustain access to care and viral suppression is not well known. …

Ouganda, us, gb, Zambie (code pays fourni par la source)

The Landscape of Non-Communicable Disease (NCD) Clinical Trials in Africa

Atwine Daniel, Elna Owembabazi, Juliet Mwanga-Amumpaire, June Fabian et autres

Growing recognition of NCDs as a major threat to health and development in Africa has generated increasing interest in strengthening research systems capable of producing locally relevant evidence. However, effective investment and policy decisions require a comprehensive understanding of the existing evidence …

The Uganda Aging Cohort Study: Current Lessons and Future Opportunities

Stephen Asiimwe, Moses Acan, Samuel Maling, Noeline Nakasujja et autres

BACKGROUND: Over 25 million people with HIV (PWH) in sub-Saharan Africa (sSA) are reaching older age in light of the success of antiretroviral therapy (ART). Older PWH are hypothesised to experience a greater burden of Alzheimer's disease and related dementias (ADRDs) due …

Ouganda, us, Zambie (code pays fourni par la source)

Chronic HIV Infection Association with Cognition and ADRD Plasma Biomarkers in Uganda

Jeremy A. Tanner, Roslyn Valdespino, Tiffany F. Kautz, Godfrey Masette et autres

Abstract Background Sub‐Saharan Africa (sSA) is projected to have the fastest population growth in older adults globally, a >250% increase in Alzheimer's Disease (AD), and rapid growth in older people living with HIV (PLWH) well‐treated on antiretroviral therapies (ARTs) in the coming …

us, Ouganda, gb (code pays fourni par la source)

Adaptation and Validation of Brief Tablet‐Based Cognitive Assessment Tool in Uganda

Roslyn Valdespino, Gabrielle Hromas, Chen‐Pin Wang, Robert Paul et autres

BACKGROUND: Sub-Saharan Africa (SSA) faces accelerated growth of older adults, older people living with HIV (PLWH), and Alzheimer's Disease (AD). However, there is a shortage of human resources and contextually relevant diagnostic tools to assess cognitive impairment (CI) in the region. The …

us, Ouganda, gb (code pays fourni par la source)

Plasma Biomarker Association with Cognition in Uganda

Jeremy A. Tanner, Roslyn Valdespino, Tiffany F. Kautz, Godfrey Masette et autres

Abstract Background Over 60% of individuals with ADRDs live in low‐ and middle‐income countries (LMICs). Sub‐Saharan Africa (SSA) is projected to have the fastest growth in older adults, including people living with HIV (PLWH). Plasma ADRD biomarkers are promising diagnostic tools, but …

us, Ouganda, gb (code pays fourni par la source)

Virologic characteristics of SARS-CoV-2 infection across evolving Omicron subvariants

Julie Boucau, Owen T. Glover, Caitlin Marino, Gregory E. Edelstein et autres

BACKGROUNDSARS-CoV-2 has evolved subvariants since the emergence of the Omicron variant in 2021. Whether these changes impact viral shedding and transmissibility is not known.METHODSPOSITIVES is a prospective longitudinal cohort of individuals with mild SARS-CoV-2 infection. Ambulatory, immunocompetent participants who did not receive …

us, Afrique du Sud (code pays fourni par la source)