Jolina Lombardi

Coronary artery disease and neurocognitive performance among older adults in Uganda

Richard Migisha, Jolina Lombardi, Pauline Byakika‐Kibwika, Noeline Nakasujja et autres

Ouganda, us (code pays fourni par la source)

Longitudinal functional network connectivity changes across the clinical stages of C9orf72 hexanucleotide repeat expansion carriers

Liwen Zhang, Suvi Häkkinen, Youjin Jung, Maria Luisa Mandelli et autres

INTRODUCTION: Intrinsic functional connectivity network abnormalities in C9orf72 hexanucleotide repeat expansion carriers emerge during the asymptomatic phase, yet longitudinal studies remain limited. We examined cross-sectional abnormalities and longitudinal connectivity changes across clinical stages. METHODS: We analyzed task-free functional magnetic resonance imaging (fMRI) …

cn, us (code pays fourni par la source)

Survival estimates and their predictors in genetic frontotemporal dementia: an international, retrospective, cohort study

Arabella Bouzigues, Mario Grassi, Valentina Cantoni, Enrico Premi et autres

BACKGROUND: What drives the heterogeneity of survival estimates in genetic frontotemporal dementia is unknown. We sought to understand the natural history and predictors of disease trajectory, which are crucial not only for effective care but also for the design of therapeutic clinical …

ca, gb, it, nl, es, se, be, pt, de, fr, fi (code pays fourni par la source)

Trajectories of brain structure and function in young adult carriers of genetic frontotemporal dementia variants

Isis So, Jolina Lombardi, Adam M. Staffaroni, Kristy Coleman et autres

ABSTRACT Background and Objectives Converging evidence hints at neurodevelopmental effects in genetic frontotemporal degeneration (FTD). In cross-sectional studies, for some genes, young adult FTD variant carriers show differences in brain volumes and cognition compared to familial non-carriers. However, longitudinal trajectories may more …

ca, us, gb, nl, it, be, fr, fi, de, es, pt, se (code pays fourni par la source)

Peripheral microRNA signature in genetic frontotemporal dementia—findings from the GENFI initiative

Chiara Fenoglio, María Serpente, Marina Arcaro, Tiziana Carandini et autres

Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT, GRN, and C9ORF72. Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to …

it, gb, nl, es, ca, se, us, be, pt, de, fr, my (code pays fourni par la source)

Educational attainment and sex modulate clinical outcomes in genetic frontotemporal dementia

Enrico Premi, Damiano Archetti, Alberto Redolfi, Valeria Bracca et autres

Abstract Individuals with autosomal dominant frontotemporal dementia (FTD) exhibit considerable variability in disease onset and progression. Both modifiable and non-modifiable factors—such as sex, educational attainment or geographic region of residence—may contribute to this heterogeneity, potentially through their influence on cognitive reserve. The …

it, us, fr, gb, nl, es, ca, se, ru, be, pt, de, hk (code pays fourni par la source)

Bridging neurodevelopment and neurodegeneration in genetic frontotemporal dementia and Alzheimer's disease

Youjin Jung, Jolina Lombardi, Rowan Heffelfinger, Sarah Inkelis et autres

BACKGROUND: The current conceptualization of genetic frontotemporal dementia (FTD) and Alzheimer's disease (AD) is that they are neurodegenerative diseases characterized by symptoms that develop late in life. Yet, studies in animal models and humans support the notion that autosomal dominant genes, whose …

us, gb (code pays fourni par la source)

Longitudinal functional network connectivity changes across the clinical stages of C9orf72 hexanucleotide repeat expansion carriers

Liwen Zhang, Suvi Häkkinen, Youjin Jung, Maria Luisa Mandelli et autres

ABSTRACT INTRODUCTION Intrinsic functional connectivity network abnormalities in C9orf72 hexanucleotide repeat expansion carriers emerge during the asymptomatic phase, yet longitudinal studies remain limited. We examined cross-sectional abnormalities and longitudinal connectivity changes across clinical stages. METHODS We analyzed task-free fMRI and structural MRI …

cn, us (code pays fourni par la source)

Cellular signatures underlying functional resilience in presymptomatic frontotemporal dementia

Kamen A. Tsvetanov, Maura Malpetti, P. Simon Jones, Timothy Rittman et autres

Frontotemporal dementia (FTD) shows autosomal dominant transmission in up to a third of families, enabling the study of presymptomatic and prodromal phases. Despite self-reported well-being and normal daily cognitive functioning, brain structural changes are evident a decade or more before the expected …

gb, pt, de, it, nl, es, ca, se, ru, us, be, fr (code pays fourni par la source)

Cerebrovascular Reactivity at Rest and Its Association With Cognitive Function in People With Genetic Frontotemporal Dementia

Ivana Kancheva, Arabella Bouzigues, Lucy L. Russell, Phoebe H. Foster et autres

BACKGROUND AND OBJECTIVES: Cerebrovascular reactivity (CVR) is an indicator of cerebrovascular health, and its signature in familial frontotemporal dementia (FTD) remains unknown. The primary aim was to investigate CVR in genetic FTD using an fMRI index of vascular contractility termed resting-state fluctuation …

nl, gb, es, ca, se, it, us, be, pt, de, fr (code pays fourni par la source)

Multiparametric MRI-based biomarkers in the non-fluent and semantic variants of primary progressive aphasia

Marco Michelutti, Hans‐Jürgen Huppertz, Heiko Volkmann, Sarah Anderl‐Straub et autres

BACKGROUND: The non-fluent (nfPPA) and semantic (svPPA) variants of primary progressive aphasia exhibit distinct clinical features. We investigated whether diffusion tensor imaging (DTI) and atlas-based volumetry (ABV) could reveal divergent patterns of longitudinal changes in brain white matter microstructure and gray matter …

it, de, ch (code pays fourni par la source)

Anatomical progression of genetic frontotemporal lobar degeneration across the lifespan

Vincent Planche, Boris Mansencal, Vladimir Fonov, José V. Manjón et autres

The recent development of brain charts for the human lifespan offers an ideal modelling framework for pathologies such as genetic frontotemporal lobar degeneration (FTLD) which likely involve both neurodevelopmental and neurodegenerative processes over a lifetime. We have therefore combined this new methodological …

fr, ca, es, gb, nl, se, ru, it, be, pt, de, us (code pays fourni par la source)