Nicholas Rachmaninoff

Single‐Cell Profiling Identifies Skin‐Resident Memory CD4 + T Cells as a Potential Correlate of Immunity During Staphylococcus aureus Skin Infection

Jonah Clegg, Giovanni Cova, Alberto Carignano, Megan Smith et autres

ABSTRACT Staphylococcus aureus is a leading cause of skin and soft tissue infections (SSTIs), yet the cellular mediators of protective memory remain incompletely defined. Using a self‐resolving murine SSTI model, we combined longitudinal single‐cell RNA sequencing with flow cytometry to characterize immune …

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Longitudinal single cell multi-omic profiling of Nicaraguan children reveals trajectories of pediatric immune development and variation 2840

Leon Bichmann, Nicholas Rachmaninoff, Stephen J. Popper, Neha M. Bansal et autres

Abstract Description The state of the immune system varies widely within individuals over time and between populations. These variations make it difficult to predict the response to infection, vaccination, and other stimuli. Recent studies have begun to highlight how age, sex, genes, …

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GZMK+CD8+ T cells target a specific acinar cell type in Sjögren's disease

Thomas J. F. Pranzatelli, Paola Pérez, Anson T. Ku, Bruno Fernandes Matuck et autres

OBJECTIVES: Sjögren's disease (SjD) is a systemic autoimmune disorder characterized by dysfunction of exocrine glands, particularly the salivary and lacrimal glands, with no clear etiology or effective therapy. This study explores the complex interplay of varied cell types in the salivary glands …

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Acute and persistent responses after H5N1 vaccination in humans

Richard Apps, Angélique Biancotto, Julián Candia, Yuri Kotliarov et autres

To gain insight into how an adjuvant impacts vaccination responses, we use systems immunology to study human H5N1 influenza vaccination with or without the adjuvant AS03, longitudinally assessing 14 time points including multiple time points within the first day after prime and …

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GZMK+CD8+ T cells Target A Specific Acinar Cell Type in Sjögren’s Disease

Thomas J. F. Pranzatelli, Paola Pérez, Anson T. Ku, Bruno Fernandes Matuck et autres

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A unified metric of human immune health

Rachel Sparks, Nicholas Rachmaninoff, William W. Lau, Dylan Hirsch et autres

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GZMK+CD8+ T cells Target a Specific Acinar Cell Type in Sjögren’s Disease

Blake M. Warner, Thomas J. F. Pranzatelli, Paola Pérez, Anson T. Ku et autres

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Sex and prior exposure jointly shape innate immune responses to a live herpesvirus vaccine

Foo Cheung, Richard Apps, Lesia K. Dropulic, Yuri Kotliarov et autres

Background: Both sex and prior exposure to pathogens are known to influence responses to immune challenges, but their combined effects are not well established in humans, particularly in early innate responses critical for shaping subsequent outcomes. Methods: We employed systems immunology approaches …

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Author response: Sex and prior exposure jointly shape innate immune responses to a live herpesvirus vaccine

Foo Cheung, Richard Apps, Lesia K. Dropulic, Yuri Kotliarov et autres

In a study of a herpes simplex virus (HSV) vaccine, the combination of sex and prior exposure to the virus resulted in HSV naive women mounting a prominent type I interferon response associated with reduced neutralizing titers to HSV.

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Early human B cell signatures of the primary antibody response to mRNA vaccination

Lela Kardava, Nicholas Rachmaninoff, William W. Lau, Clarisa M. Buckner et autres

Messenger RNA (mRNA) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are highly effective at inducing protective immunity. However, weak antibody responses are seen in some individuals, and cellular correlates of immunity remain poorly defined, especially for B cells. Here we …

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Pre-vaccination and early B cell signatures of the antibody response to SARS-CoV-2 mRNA vaccine

Lela Kardava, Nicholas Rachmaninoff, William W. Lau, John S. Tsang et autres

The data presented in Code repository for Kardava, L., Rachmaninoff, N., Lau, W. W., Buckner, C. M., Trihemasava, K., Blazkova, J., ... & Moir, S. (2022). Early human B cell signatures of the primary antibody response to mRNA vaccination. Proceedings of the …

Pre-vaccination and early B cell signatures of the antibody response to SARS-CoV-2 mRNA vaccine

Lela Kardava, Nicholas Rachmaninoff, William W. Lau, John S. Tsang et autres

The data presented in Code repository for Kardava, L., Rachmaninoff, N., Lau, W. W., Buckner, C. M., Trihemasava, K., Blazkova, J., ... & Moir, S. (2022). Early human B cell signatures of the primary antibody response to mRNA vaccination. Proceedings of the …