Ji-Hoon Jang

Prognostic Implications of High Platelet Reactivity According to DAPT Score After Drug-eluting Stent Implantation: Insight from the PTRG-DES Consortium

Seong Huan Choi, K J Lee, Ji-Hoon Jang, Yong‐Soo Baek et autres

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Precision Pharmacokinetics of Quetiapine: A Physiologically Based Model Incorporating Liver Cirrhosis and CYP3A4 Polymorphisms

Seung Min Lee, Ji-Hoon Jang, Seung‐Hyun Jeong

Quetiapine, an atypical antipsychotic primarily metabolized by CYP3A4, exhibits altered pharmacokinetics (PK) in patients with liver cirrhosis and individuals with CYP3A4 polymorphisms. This study aimed to develop and validate a physiologically based pharmacokinetic (PBPK) model to predict the effects of hepatic impairment …

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Identifying PRKAG2 syndrome—a rare cause of wolff-Parkinson-white syndrome and left ventricular hypertrophy: a case report

Ji-Hoon Jang, Yong‐Soo Baek, Woori Jang, Dae-Young Kim et autres

Background: In young patients presenting with Wolff-Parkinson-White syndrome and left ventricular hypertrophy (LVH), a genetic aetiology should be considered, particularly when cardiovascular risk factors such as hypertension or valvular heart disease are not present, or when there is a suggestive family history …

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ASSOCIATION BETWEEN FREQUENT HOME BLOOD PRESSURE MEASUEMENT AND BLOOD PRESSURE CONTROL RATE IN HYPERTENSIVE PATIENTS

Eun Mi Lee, Jin Oh Na, Ji-Hoon Jang, Sung‐Hee Shin

Objective: Home blood pressure measurement (HBPM) is recommended for accurate diagnosis and effective management of hypertension. Prior studies have demonstrated that HBPM is more closely associated with target organ damage and cardiovascular outcomes than office BP measurements. However, real-world data on the …

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Association of Right Ventricular–Pulmonary Arterial Coupling and Progression of Tricuspid Regurgitation in Patients With Atrial Fibrillation

Dae‐Young Kim, Sung Kee Ryu, Ji-Hoon Jang, Seong‐Huan Choi et autres

Background Tricuspid regurgitation (TR) severity is associated with poor prognosis in patients with atrial fibrillation (AF). Recently, right ventricular–pulmonary arterial (RV‐PA) coupling has been shown to be related to clinical outcomes in patients with TR. However, data on the relationship of RV‐PA …

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Use of artificial intelligence-powered ECG to differentiate between cardiac and pulmonary pathologies in patients with acute dyspnoea in the emergency department

Ji-Hoon Jang, Sang‐Won Lee, Daeyoung Kim, Sung‐Hee Shin et autres

BACKGROUND: Acute dyspnoea is common in acute care settings. However, identifying the origin of dyspnoea in the emergency department (ED) is often challenging. We aimed to investigate whether our artificial intelligence (AI)-powered ECG analysis reliably distinguishes between the causes of dyspnoea and …

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Beyond One-Size-Fits-All: Tailoring Teicoplanin Regimens for Normal Renal Function Patients Using Population Pharmacokinetics and Monte Carlo Simulation

Yong-Kyun Kim, Kyeong-Min Jo, Jaeha Lee, Ji-Hoon Jang et autres

In patients with normal renal function, significant teicoplanin dose adjustments are often necessary. This study aimed to develop a population pharmacokinetic (PK) model for teicoplanin in healthy adults and use it to recommend optimal dosage regimens for patients with normal renal function. …

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Intrapulmonary and Systemic Pharmacokinetics of Colistin Following Nebulization of Low-Dose Colistimethate Sodium in Patients with Ventilator-Associated Pneumonia Caused by Carbapenem-Resistant Acinetobacter baumannii

Dong Hwan Lee, Shin Young Kim, Yong-Kyun Kim, Soyoung Jung et autres

Colistimethate sodium (CMS) nebulization is associated with reduced systemic toxicity compared to intravenous injection, with potentially enhanced clinical efficacy. This study aimed to assess the pharmacokinetic (PK) properties of colistin during low-dose CMS nebulization in patients with ventilator-associated pneumonia (VAP) caused by …

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Epithelial Yap/Taz are required for functional alveolar regeneration following acute lung injury

Gianluca T. DiGiovanni, Wei Han, Taylor P. Sherrill, Chase J. Taylor et autres

A hallmark of idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases is dysregulated repair of the alveolar epithelium. The Hippo pathway effector transcription factors YAP and TAZ are implicated as essential for type 1 and type 2 alveolar epithelial cell (AT1 …

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Epithelial Yap/Taz are required for functional alveolar regeneration following acute lung injury

Gianluca T. DiGiovanni, Wei Han, Taylor P. Sherrill, Chase J. Taylor et autres

Abstract A hallmark of idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases is dysregulated repair of the alveolar epithelium. The Hippo pathway effector transcription factors YAP and TAZ have been implicated as essential for type 1 and type 2 alveolar epithelial …

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New Prognostic Scoring System for Mortality in Idiopathic Pulmonary Fibrosis by Modifying the Gender, Age, and Physiology Model With Desaturation During the Six-minute Walk Test

Ji-Hoon Jang, J.H. Lee

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Dosage exploration of meloxicam according to CYP2C9 genetic polymorphisms based on a population pharmacokinetic‐pharmacodynamic model

Ji-Hoon Jang, Seung‐Hyun Jeong, Yong‐Bok Lee

Abstract Background Meloxicam, used for treating inflammatory diseases, shows large differences in metabolism according to CYP2C9 genetic polymorphisms; however, there are few studies on dose regimen setting based on quantitative predictions. Objective The aim of this study was to determine the appropriate …

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