Cheng Peng

Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injury

Yaying Zhu, Chengxiang Deng, Bo Chen, Jia He et autres

Hepatocytes undergo extensive proliferation to facilitate liver repair after injury, yet early adaptive changes prior to proliferation remain unclear. Here, we report that during early acetaminophen (APAP)-induced liver injury, hepatocytes exhibit transient proliferation suppression that is most pronounced in mid-zone hepatocytes, consistent …

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The cell-type specific interaction based drug repurposing for psychiatric disorders

Yiyuli Tang, Yuzhuo Zhou, Zhenning Wei, Yan Wen et autres

Psychiatric disorders severely challenge the public health, but the development of new psychotropic medications cannot keep pace with clinical needs. The rapid accumulation of single-cell RNA data provides opportunities to develop new computational approaches of drug repurposing. However, there is a lack …

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The C9orf72/SMCR8 complex maintains microglial homeostasis via RAB8A-ESCRT-mediated lysosomal repair

Shan Li, Shidong Xu, Feng Li, Qirui Zhao et autres

Microglia are critical regulators of neuroinflammation and neurodegeneration. Haploinsufficiency of C9orf72, the most frequently mutated gene in amyotrophic lateral sclerosis and frontotemporal dementia, has been linked to autophagy-lysosomal pathway defects, but the role of C9orf72 in microglia remains unclear. Here, we identify …

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scTumorDrug: predicting cell-type-specific drug responses for heterogeneous tumors

Qiang Zhang, Q J Zhang, Chunming Guo, Cheng Peng

It is important to predict cell-type-specific drug responses within the heterogeneous tumors for precision medicine. The single-cell RNA sequencing (scRNA-seq) technique together with drug responses data provides opportunities for this mission. The previous methods were mainly evaluated in datasets derived from cancer …

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Ferroptosis as a therapeutic vulnerability in ARID1A-deficient bladder cancer

Mengxue Zhao, Xuefeng Wang, Xianbin Duan, Chunyue Wu et autres

ARID1A is among the most frequently mutated genes in bladder cancer, yet no targeted therapy exists for this molecular subset. Here, we identify ferroptosis induction as a synthetic lethal strategy in ARID1A-deficient bladder cancer. We found that ARID1A loss impaired the NRF2-SLC7A11-glutathione …

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A Parameter-Efficient Transfer Learning Approach through Multitask Prompt Distillation and Decomposition for Clinical NLP

Cheng Peng, Mengxian Lyu, Ziyi Chen, Yonghui Wu

Existing prompt-based fine-tuning methods typically learn task-specific prompts independently, imposing significant computing and storage overhead at scale when deploying multiple clinical natural language processing (NLP) systems. We present a multitask prompt distillation and decomposition framework that learns a single shared metaprompt from …

Mechanisms of Phillygenin and Forsythiaside A in Liver Fibrosis Based on Hepatocyte-Derived Exosomes

Shenglin Zhang, Lihong Gong, Yuxin Yao, Yanzhi Li et autres

Liver fibrosis is a dynamic process characterized by excessive extracellular matrix (ECM) deposition due to chronic liver injury. Emerging evidence highlights the pivotal role of intercellular crosstalk in hepatic fibrogenesis, particularly via exosomes mediated communication. Forsythia suspensa (Thunb.) Vahl, a traditional Chinese …

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Correction to “A Bioinspired Nanovaccine for Personalized Cancer Immunotherapy”

Lanqing Luo, Junyao Li, Xueying Shen, Xinyan Li et autres

Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injury

Yaying Zhu, Chengxiang Deng, Bo Chen, Jia He et autres

Hepatocytes undergo extensive proliferation to facilitate liver repair after injury, yet early adaptive changes prior to proliferation remain unclear. Here, we report that during early acetaminophen (APAP)-induced liver injury, hepatocytes exhibit transient proliferation suppression that is most pronounced in mid-zone hepatocytes, consistent …

cn (code pays fourni par la source)

Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injury

Chengxiang Deng, Bo Chen, Jia He, Yanan Liu et autres

Hepatocytes undergo extensive proliferation to facilitate liver repair after injury, yet early adaptive changes prior to proliferation remain unclear. Here, we report that during early acetaminophen (APAP)-induced liver injury (AILI), hepatocytes exhibit transient proliferation suppression, most pronounced in mid-zone hepatocytes due to …

cn (code pays fourni par la source)

Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injury

Chengxiang Deng, Bo Chen, Jia He, Yanan Liu et autres

Abstract Hepatocytes undergo extensive proliferation to facilitate liver repair after injury, yet early adaptive changes prior to proliferation remain unclear. Here, we report that during early acetaminophen (APAP)-induced liver injury, hepatocytes exhibit transient proliferation suppression that is most pronounced in mid-zone hepatocytes, …

cn (code pays fourni par la source)

A single-cell V(D)J sequencing dataset of peripheral blood cells in multibacillary leprosy

Zhe Li, Jie Jia, Qiang Zhang, Huifang Tan et autres

Leprosy is a chronic infectious disease caused by Mycobacterium leprae (Mlep), and is classified as a tropical disease by the WHO. While prior research has documented the various phenotypes and functions of T cells and B cells in Mlep infection, the specific …

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