Paul B. Rosenberg

Prognostic Value of Blood-Based P-Tau217 Levels for Progression to Cognitive Impairment

Rachel F. Buckley, Diana L Townsend, Colin Birkenbihl, Madison Cuppels et autres

Importance: Blood-based biomarkers for Alzheimer disease, particularly plasma phosphorylated tau 217 (p-tau217), accurately reflect early Alzheimer disease brain pathology in cognitively unimpaired individuals, but estimates of absolute risk of progression to cognitive impairment across multiple cohorts are needed. Objective: To estimate absolute …

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Predictors of cognitive resilience in the old‐old: An observational study using real‐world electronic health record data

Konstantina Skolariki, Paul B. Rosenberg, Esther S Oh, Jeannie Leoutsakos et autres

INTRODUCTION: Understanding factors associated with cognitive resilience is critical for developing interventions to preserve cognitive health in the old-old. Our aim is identifying clinical predictors of cognitive resilience in a large real-world cohort of adults aged 75+. METHODS: Longitudinal analysis of electronic …

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Amyloid Imaging and APOE Genotype Disclosure and Short-Term Psychological Distress

Joshua D. Grill, REMA RAMAN, Shunran Wang, Karin B. Ernstrom et autres

Importance: Alzheimer disease (AD) biomarker and genetic testing results are increasingly disclosed to cognitively unimpaired adults in research and could in the future inform clinical treatment decisions in this population. Objectives: To assess psychological outcomes after returning 3 categories of amyloid biomarker …

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Non-invasive MRI mapping of tissue-CSF water exchange reveals glymphatic fluid movement in live human cortex

Z. Wang, Zhiyi Hu, Dengrong Jiang, Jie Song et autres

Efficient metabolic waste clearance, via the postulated glymphatic system, is essential for neural homeostasis. However, direct visualization of tissue-cerebrospinal fluid (CSF) exchange remains limited, leading to ongoing debate in the neuroscientific field. The present work revealed evidence of tissue-CSF water exchange in …

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Blood biomarkers for Alzheimer's disease are correlated with measures of agitation and cognition in a randomized trial assessing the effects of escitalopram on agitation

Maansi Barnwal, Sheriza Baksh, Zahinoor Ismail, David M. Shade et autres

Abstract INTRODUCTION Escitalopram for Agitation in Alzheimer's Disease (S‐CitAD) is a National Institutes of Health–funded randomized controlled trial that randomized 173 participants with clinically diagnosed Alzheimer's disease (AD) and agitation to escitalopram or placebo for 12 weeks, assessing efficacy and safety. There …

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Impact of long-term systolic blood pressure on cognitive disorder risk: Across different age groups and antihypertensive medication timing

Konstantina Skolariki, Paul B. Rosenberg, Sevil Yaşar, Esther S. Oh et autres

BackgroundElevated blood pressure (BP) is considered a risk factor for cognitive disorders. This study examined the continuous relationship between 2-year mean systolic BP (SBP) and incident cognitive disorders in a large, real-world primary care cohort.ObjectiveTo evaluate the associations of 2-year mean SBP …

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Elevated brain oxygen extraction fraction (OEF) as a potential marker for vascular cognitive impairment and dementia

Jie Song, Wen Shi, Julia Suconic, Kaisha Hazel et autres

BACKGROUND: Vascular cognitive impairment and dementia (VCID) is the second most common cause of cognitive impairment in older adults. However, identifying reliable biomarkers for VCID remains challenging. Cerebral Oxygen-extraction-fraction (OEF), a key hemodynamic parameter of brain function, has been found elevated in …

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Elevated brain oxygen extraction fraction (OEF) as a potential marker for vascular cognitive impairment and dementia

Jie Song, Wen Shi, Julia Suconic, Kaisha Hazel et autres

BACKGROUND: Vascular cognitive impairment and dementia (VCID) is the second most common cause of cognitive impairment in older adults. However, identifying reliable biomarkers for VCID remains challenging. Cerebral Oxygen-extraction-fraction (OEF), a key hemodynamic parameter of brain function, has been found elevated in …

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Sleep variables in the S‐CitAD RCT of escitalopram for agitation in Alzheimer's disease

Paul B. Rosenberg, Carol A Manning, Anton P. Porsteinsson, Kostas G. Lyketsos et autres

BACKGROUND: Sleep commonly is disturbed in Alzheimer's disease (AD) and poor sleep may accelerate AD progression. Disturbed sleep may contribute to neuropsychiatric symptoms (NPS) of AD, including agitation. We examined associations between actigraphic sleep parameters with baseline agitation and changes in agitation …

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Who stands to lose the most: impact of delirium on long‐term cognitive impairment in a hip fracture repair cohort

Mfon E. Umoh, Anirudh Sharma, Jeannie‐Marie Leoutsakos, Kostas G. Lyketsos et autres

BACKGROUND: Delirium, an acute disorder of attention and cognition, is a potentially preventable contributor to poor outcomes in older adults including future cognitive decline. The goal of this study was to determine the cognitive impact of postoperative delirium on patients who underwent …

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Correction: Five-year dementia prediction and decision support system based on real-world data

Themis P. Exarchos, Georgios Dimakopoulos, Konstantinos Lazaros, Marios G. Krokidis et autres

[This corrects the article DOI: 10.3389/fnagi.2025.1670609.].

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A Randomized Controlled Trial of the Safety and Efficacy of Dronabinol for Agitation in Alzheimer’s Disease

Paul B. Rosenberg, Halima Amjad, Haroon Burhanullah, Milap A. Nowrangi et autres

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