Kaisha Hazel

Cerebral oxygen extraction fraction as a physiological biomarker in vascular cognitive impairment: A study in older adults enriched for small vessel diseases

Jie Song, Wen Shi, Julia Suconic, Kaisha Hazel et autres

INTRODUCTION: Vascular cognitive impairment and dementia (VCID) is a common cause of cognitive impairment, yet validated biomarkers, particularly those reflecting vascular function, remain lacking. Oxygen extraction fraction (OEF), which reflects the functional status of cerebral small vessels, is a potential physiological biomarker …

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Non-invasive MRI mapping of tissue-CSF water exchange reveals glymphatic fluid movement in live human cortex

Z. Wang, Zhiyi Hu, Dengrong Jiang, Jie Song et autres

Efficient metabolic waste clearance, via the postulated glymphatic system, is essential for neural homeostasis. However, direct visualization of tissue-cerebrospinal fluid (CSF) exchange remains limited, leading to ongoing debate in the neuroscientific field. The present work revealed evidence of tissue-CSF water exchange in …

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Elevated brain oxygen extraction fraction (OEF) as a potential marker for vascular cognitive impairment and dementia

Jie Song, Wen Shi, Julia Suconic, Kaisha Hazel et autres

BACKGROUND: Vascular cognitive impairment and dementia (VCID) is the second most common cause of cognitive impairment in older adults. However, identifying reliable biomarkers for VCID remains challenging. Cerebral Oxygen-extraction-fraction (OEF), a key hemodynamic parameter of brain function, has been found elevated in …

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Elevated brain oxygen extraction fraction (OEF) as a potential marker for vascular cognitive impairment and dementia

Jie Song, Wen Shi, Julia Suconic, Kaisha Hazel et autres

BACKGROUND: Vascular cognitive impairment and dementia (VCID) is the second most common cause of cognitive impairment in older adults. However, identifying reliable biomarkers for VCID remains challenging. Cerebral Oxygen-extraction-fraction (OEF), a key hemodynamic parameter of brain function, has been found elevated in …

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The role of venous hemodynamics in cerebral small vessel disease

Wen Shi, Dengrong Jiang, Jie Song, Yifan Gou et autres

Motivation: Post-mortem studies suggested that vascular cognitive impairment and dementia (VCID) are more strongly related to small vein abnormalities than to arteriolosclerosis. However, few studies have investigated the relationship between venous dysfunction and VCID in vivo. Goal(s): To study the role of …

Elevated regional cerebral oxygen extraction fraction was associated with worse cognitive performance in older adults with vascular risks

Jie Song, Wen Shi, Julia Suconic, Kaisha Hazel et autres

Motivation: Cognitive impairment from vascular disease lacks clear biomarkers, complicating early detection. Brain oxygen-extraction-fraction (OEF), an indicator of oxygen utilization, may reveal vascular contributions to cognitive decline, especially in executive function. Goal(s): We aimed at investigating the relationship between cortical and subcortical …

Cerebrovascular reactivity (CVR) MRI as a biomarker for cerebral small vessel disease (SVD) related cognitive decline: Multi‐site validation in the MarkVCID Consortium

Peiying Liu, Zixuan Lin, Kaisha Hazel, George Pottanat et autres

Abstract Background Cerebral small vessel disease (SVD) related vascular contributions represent a major factor contributing to cognitive decline and dementia (VCID) in older adults. However, there has not been a validated biomarker for the diagnosis and treatment monitoring of this condition. Recently, …

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Cerebrovascular reactivity (CVR) MRI as a biomarker for cerebral small vessel disease (SVD) related cognitive decline: Multi‐site validation in the MarkVCID Consortium

Peiying Liu, Zixuan Lin, Kaisha Hazel, George Pottanat et autres

Abstract Background Cerebral small vessel disease (SVD) related vascular contributions represent a major factor contributing to cognitive decline and dementia (VCID) in older adults. However, there has not been a validated biomarker for the diagnosis and treatment monitoring of this condition. Recently, …

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Gas-free cerebrovascular reactivity predicts cognition in older individuals

L. Donaldson, Beini Hu, Mahsa Mayeli, Huajun Liang et autres

Motivation: Small-vessel-disease (SVD), a contributing risk factor in vascular cognitive impairment and dementia (VCID), needs sensitive biomarkers to assess the brain. Goal(s): Our goal is to evaluate whether gas-free cerebrovascular reactivity (CVR) can predict cognitive function in older individuals. Approach: We performed …

Cognitive impairment is associated with elevated oxygen extraction and metabolism in the medial temporal lobe

Jie Song, Wen Shi, Kaisha Hazel, Ebony Jones et autres

Motivation: Currently, the primary MRI-based biomarker for cognitive dysfunction is the atrophy of medial-temporal-lobe (MTL). However, MTL atrophy represents a late stage of tissue damage. Functional biomarkers such as the MTL oxygen metabolism may be more sensitive in early stages. Goal(s): To …

Cerebrovascular reactivity in choroid plexus

Yue Jin, Monroe P. Turner, Kaisha Hazel, Yuguang Zhao et autres

Motivation: Choroid plexus (CP) plays an important role in the production of CSF and the formation of the blood-CSF barrier, but its vascular function is unclear. Goal(s): We aim to quantify cerebrovascular reactivity (CVR) of CP in normal controls. Approach: We applied …

Validation and assessment of venous transit time in the human brain using VICTR MRI

Wen Shi, Dengrong Jiang, Zhiyi Hu, Kaisha Hazel et autres

Motivation: Venous transit time (VTT) is insufficiently investigated and can be a useful marker for clinical populations with abnormalities in the cerebral venous system. Goal(s): To further verify a novel non-contrast VICTR MRI and investigate advanced VTT properties and their age effects …