Roberto de la Rica

Diagnostic accuracy of PCT, IL-6, and MR-ProADM for early identification of sepsis in the emergency department

Sofía Tejada, Antonio Clemente, Antònia Socías, Andrés Giglio et autres

OBJECTIVE: To evaluate the diagnostic accuracy of the biomarkers procalcitonin (PCT), interleukin-6 (IL-6), and mid-regional pro-adrenomedullin (MR-ProADM), individually and in combination, for early detection of sepsis and septic shock during emergency department (ED) triage. MATERIALS AND METHODS: A retrospective observational study was …

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Hospital-Wide Sepsis Detection: A Machine Learning Model Based on Prospectively Expert-Validated Cohort

Marcío Borges-Sa, Andres Giglio, Maria Aranda, Antònia Socías et autres

Background/Objectives: Sepsis detection remains challenging due to clinical heterogeneity and limitations of traditional scoring systems. This study developed and validated a hospital-wide machine learning model for sepsis detection using retrospectively developed data from prospectively expert-validated cases, aiming to improve diagnostic accuracy beyond …

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Hospital-Wide Sepsis Detection: A Machine Learning Model Based on Prospectively Expert-Validated Cohort

Marcío Borges-Sa, Andrés Giglio, María Aranda, Antònia Socías et autres

Background/Objectives: Sepsis detection remains challenging due to clinical heterogene-ity and limitations of traditional scoring systems. This study developed and validated a hospital-wide machine learning model for sepsis detection using retrospectively devel-oped data from prospectively expert-validated cases, aiming to improve diagnostic accu-racy beyond …

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Plug-in paper biosensors for the rapid detection of multiple sepsis biomarkers in blood at the emergency department

Francisco M. Bouzada, Bartomeu Mestre, Andreu Vaquer, Sofía Tejada et autres

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Circulating NETs enable early identification of thrombotic risk in sepsis at emergency care onset

Sofía Tejada, Antonio Clemente, Antònia Socías, María Aranda et autres

Introduction: Sepsis involves a dysregulated host response to infection and is frequently complicated by coagulopathy, contributing to organ dysfunction and mortality. Early detection of coagulation disturbances in the emergency department (ED) remains clinically challenging. Neutrophil extracellular traps (NETs) have emerged as key …

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NanoArrayPAD−X: Nanoprobe Array and 3D-µPAD for the Simultaneous Detection of Respiratory Pathogens and Biomarkers at the Point of Care

Andreu Vaquer, Francisco M. Bouzada, Sofía Tejada, Antonio Clemente et autres

Microfluidic paper-based analytical devices (µPADs) are ideal for point-of-care diagnostics due to their low cost, compact size, and ease of use. However, current designs have limited multiplexing capabilities, making it difficult to simultaneously detect pathogens and biomarkers in the same sample. In …

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Decoding Sepsis: A 16-Year Retrospective Analysis of Activation Patterns, Mortality Predictors, and Outcomes from a Hospital-Wide Sepsis Protocol

Marcío Borges-Sa, Andrés Giglio, María Aranda, Antònia Socías et autres

Background: Sepsis remains a leading cause of mortality in hospitalized patients. We evaluated characteristics and outcomes of patients identified through a comprehensive hospital-wide sepsis protocol over a 16-year period. Methods: This retrospective cohort study analyzed hospital-wide sepsis protocol activations at a tertiary …

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Decoding Sepsis: A 16-Year Retrospective Analysis of Activation Patterns, Mortality Predictors, and Outcomes from a Hospital-Wide Sepsis Protocol

Marcío Borges-Sa, Andrés Giglio, María Aranda, Antònia Socías et autres

Background: Sepsis remains a leading cause of mortality in hospitalized patients. We evaluated characteristics and outcomes of patients identified through a comprehensive hospital-wide sepsis protocol over a 16-year period. Methods: This retrospective cohort study analyzed hospital-wide sepsis protocol activations at a tertiary …

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A Nanoparticle-Based Immunoassay on Facemasks for Evaluating Neutrophilic Airway Inflammation in COPD Patients

Bartomeu Mestre, Núria Toledo-Pons, Andreu Vaquer, Sofía Tejada et autres

Patients with chronic obstructive pulmonary disease (COPD) often experience acute exacerbations characterized by elevated neutrophilic inflammation in the lungs. Currently, this condition is diagnosed through visual inspection of sputum color and volume, a method prone to personal bias and unsuitable for patients …

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Nanoparticle-Based Detection of Myeloperoxidase Adhered to Facemasks for the Non-invasive Assessment of Airway Neutrophilic Inflammation in COPD Patients

Roberto de la Rica, Bartomeu Mestre, Andreu Vaquer, Silvia Tejada et autres

Abstract RATIONALE: Myeloperoxidase (MPO) is an enzyme released by neutrophils during chronic airway inflammation whose levels increase during exacerbations in patients with chronic obstructive pulmonary disease (COPD). This study proposes the use of nanoparticle-based immunosensors as a quick, non-invasive method for detecting …

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Detecting Respiratory Pathogens for Diagnosing Lower Respiratory Tract Infections at the Point of Care: Challenges and Opportunities

Francisco M. Bouzada, Bartomeu Mestre, Andreu Vaquer, Sofía Tejada et autres

Lower respiratory tract infections (LRTIs) are a leading cause of mortality worldwide, claiming millions of lives each year and imposing significant healthcare costs. Accurate detection of respiratory pathogens is essential for the effective management of LRTIs. However, this process often relies on …

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A multirange paper-based analytical device for identifying low, moderate, and high P. aeruginosa bacterial loads in sputum samples

Cristina Adrover-Jaume, Antonio Clemente, Julia Viana-Ramírez, Estrella Rojo‐Molinero et autres

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