George A. Edwards

Deep Learning-Based Classification of Temporal Stages of AT8-Labeled Tau Pathology After Experimental Traumatic Brain Injury

Guilherme José de Antunes e Sousa, Rodrigo Afonso Sá, Marcos António Spínola Monteiro Gomes, George A. Edwards et autres

Tauopathies are characterised by a progressive accumulation of hyperphosphorylated tau. However, early and intermediate stages remain challenging to quantify due to subtle and heterogeneous morphological characteristics. This study evaluates a deep learning framework for classifying multiple temporal stages of tauopathy progression using …

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Neuronal subtype governs amyloid structure, cellular response, and cognitive outcome in genetically targeted APP mouse models

Gabriella Perez, Zoe Lai, George A. Edwards, Jacob Dundee et autres

Pathological heterogeneity is increasingly appreciated in Alzheimer’s disease, yet we do not know how distinct aggregate conformations arise or influence cognitive outcomes. In an amyloid mouse model, we found that different brain regions formed structurally distinct Aβ deposits, prompting us to test …

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Additional file 1 of Neuronal subtype governs amyloid structure, cellular response, and cognitive outcome in genetically targeted APP mouse models

Gabriella Perez, Zoe Lai, George A. Edwards, Jacob M. Dundee et autres

Supplementary Material 1

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Additional file 1 of Neuronal subtype governs amyloid structure, cellular response, and cognitive outcome in genetically targeted APP mouse models

Gabriella Perez, Zoe Lai, George A. Edwards, Jacob M. Dundee et autres

Supplementary Material 1

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Advanced Materials Metrology Strategy

A. Mark Pollard, Francisco Enrique Vicente Castro, George A. Edwards, M Gee et autres

Advanced materials are a cross-cutting technology that impacts all aspects of our lives, such as green energy, advanced medicines, quantum technologies and the future of telecommunications. The manufacturing of raw advanced materials contributes approximately £14.4 billion in GVA to the UK economy …

TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy

George A. Edwards, Caleb A. Wood, He Lin Yang, Quynh Nguyen et autres

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Malignant mixed mullerian tumors: a SEER database review of rurality and treatment modalities on disease outcome

N Hasan Zadeh, Arjun N. Bhatt, Vaishnavi Sripiparu, Melisa Pasli et autres

Introduction Malignant Mixed Mullerian Tumors (MMMT) are rare and poorly understood sarcomas with limited research on risk factors, pathogenesis, and optimal treatments. This study aimed to address this knowledge gap and explore the impact of community size, patient characteristics, disease characteristics, and …

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Hantavirus in Panama: Twenty Years of Epidemiological Surveillance Experience

Blas Armién, Carlos Muñoz, Hector Cedeño, Jacqueline R. Salazar et autres

Twenty years have passed since the emergence of hantavirus zoonosis in Panama at the beginning of this millennium. We provide an overview of epidemiological surveillance of hantavirus disease (hantavirus pulmonary syndrome and hantavirus fever) during the period 1999–2019 by including all reported …

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TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy

George A. Edwards, Caleb A. Wood, Quynh Nguyen, Peter J. Kim et autres

TMEM106B is a risk modifier for a growing list of age-associated dementias including Alzheimer’s and frontotemporal dementia, yet its function remains elusive. Two key questions that emerge from past work are whether the conservative T185S coding variant found in the minor haplotype …

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Aged Cattle Brain Displays Alzheimer's Disease-Like Pathology and Promotes Brain Amyloidosis in a Transgenic Animal Model

Inés Moreno‐González, George A. Edwards, Rodrigo A.V. Morales, Claudia A. Duran-Aniotz et autres

Alzheimer's disease (AD) is one of the leading causes of dementia in late life. Although the cause of AD neurodegenerative changes is not fully understood, extensive evidence suggests that the misfolding, aggregation and cerebral accumulation of amyloid beta (Aβ) and tau proteins …

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Longitudinal Assessment of Tau-Associated Pathology by 18F-THK5351 PET Imaging: A Histological, Biochemical, and Behavioral Study

Inés Moreno‐González, George A. Edwards, Omar Hasan, Nazaret Gamez et autres

Several common and debilitating neurodegenerative disorders are characterized by the intracellular accumulation of neurofibrillary tangles (NFTs), which are composed of hyperphosphorylated tau protein. In Alzheimer’s disease (AD), NFTs are accompanied by extracellular amyloid-beta (Aβ), but primary tauopathy disorders are marked by the …

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Induced Pluripotent Stem Cell-Derived Neural Precursors Improve Memory, Synaptic and Pathological Abnormalities in a Mouse Model of Alzheimer’s Disease

Enrique Armijo, George A. Edwards, Andrea Flores, Jorge Amado Rentería Vera et autres

Alzheimer's disease (AD) is the most common type of dementia in the elderly population. The disease is characterized by progressive memory loss, cerebral atrophy, extensive neuronal loss, synaptic alterations, brain inflammation, extracellular accumulation of amyloid-β (Aβ) plaques, and intracellular accumulation of hyper-phosphorylated …

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