Longitudinal Assessment of Tau-Associated Pathology by 18F-THK5351 PET Imaging: A Histological, Biochemical, and Behavioral Study
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Le résumé fourni par la source
Several common and debilitating neurodegenerative disorders are characterized by the intracellular accumulation of neurofibrillary tangles (NFTs), which are composed of hyperphosphorylated tau protein. In Alzheimer’s disease (AD), NFTs are accompanied by extracellular amyloid-beta (Aβ), but primary tauopathy disorders are marked by the accumulation of tau protein alone, including forms of frontotemporal dementia (FTD), corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP), among others. 18F-THK5351 has been reported to bind pathological tau as well as associated reactive astrogliosis. The goal of this study was to validate the ability of the PET tracer 18F-THK5351 to detect early changes in tau-related pathology and its relation to other pathological hallmarks. We demonstrated elevated in vivo 18F-THK5351 PET signaling over time in transgenic P301S tau mice from 8 months that had a positive correlation with histological and biochemical tau changes, as well as motor, memory, and learning impairment. This study indicates that 18F-THK5351 may help fill a critical need to develop PET imaging tracers that detect aberrant tau aggregation and related neuropathology in order to diagnose the onset of tauopathies, gain insights into their underlying pathophysiologies, and to have a reliable biomarker to follow during treatment trials.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Longitudinal Assessment of Tau-Associated Pathology by 18F-THK5351 PET Imaging: A Histological, Biochemical, and Behavioral Study
- Date Crossref
- 12/10/2021
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Biomedical Research Networking Center on Neurodegenerative Diseases pays non établi dans la noticeStructure de recherche
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Instituto de Investigación Biomédica de Málaga pays non établi dans la noticeStructure de recherche
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Universidad de Málaga pays non établi dans la noticeUniversité ou école supérieure
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The University of Texas Health Science Center at Houston Department of Neurology pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Sicences Department of Cell Biology pays non établi dans la noticeUniversité ou école supérieure
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Networking Biomedical Research Center on Neurodegenerative Diseases (CIBERBED) pays non établi dans la noticeStructure de recherche
Biomedical Research Networking Center on Neurodegenerative Diseases, Instituto de Investigación Biomédica de Málaga et Universidad de Málaga, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.