Dana L. Hasselschwert

Molecular examination of the endogenous opioid system in rhesus macaque monkeys with self‐injurious behavior

Marques Jackson, Brittany L. Foret, Jane A. Fontenot, Dana L. Hasselschwert et autres

Self-injurious behavior (SIB) can lead to serious injury and occurs in approximately 1%-4% of the adult population, with higher incidences in adolescent and institutionalized populations, as well as in children with developmental disorders such as Autism. SIB also spontaneously occurs in a …

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Tuberculosis detection in nonhuman primates is enhanced by use of testing algorithms that include an interferon-γ release assay

JoAnn L. Yee, Kamm Prongay, Koen K. A. Van Rompay, Suthirote Meesawat et autres

OBJECTIVE: To develop a testing algorithm that incorporates multiple assays to evaluate host cellular and humoral immunity and antigen detection concerning Mycobacterium tuberculosis complex (MTBC) infection in captive nonhuman primates. ANIMALS: Cohorts of captive-bred and wild-caught macaques from 5 different geographic regions. …

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Insulin-like Growth Factor 1 and Prolactin Levels in Chimpanzees (Pan troglodytes) Across the Lifespan

Anat Ben-Shlomo, Sandra M. McLachlan, Jennifer Hwe, Holly A. Aliesky et autres

Abstract As human and chimpanzee genomes show high homology for IGF1 and PRL, we analyzed the sera of 367 healthy chimpanzees obtained during routine physical examinations in a single colony and measured chimpanzee insulin-like growth factor (IGF)-1 and prolactin (PRL) levels across …

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Endogenous Specialized Proresolving Mediator Profiles in a Novel Experimental Model of Lymphatic Obstruction and Intestinal Inflammation in African Green Monkeys

Felix Becker, Emily Romero, Jason E. Goetzmann, Dana L. Hasselschwert et autres

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Dynamic gut microbiome changes following regional intestinal lymphatic obstruction in primates

Felix Becker, Felicity N. E. Gavins, Jane A. Fontenot, Paul Jordan et autres

The pathogenesis of inflammatory bowel disease (IBD) has been linked with lymphostasis, but whether and how lymphatic obstruction might disturb the intestinal microbiome in the setting of Crohn's Disease (CD) is currently unknown. We employed a new model of CD in African …

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Bacteria as Ovipositional Attractants for Aedes Aegypti (Diptera: Culicidae)

Dana L. Hasselschwert, C. Lee Rockett

The effectiveness of selected bacterial species as ovipositional attractants for Aedes aegypti was compared. Bacterial washes, in glass containers, were utilized as ovipositional substrates and subsequent egg counts determined the degree of ovipositional attractiveness. Among others, Bacillus cereus and Pseudomonas aeruginosa were …

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The Final (Oral Ebola) Vaccine Trial on Captive Chimpanzees?

Peter D. Walsh, Drishya Kurup, Dana L. Hasselschwert, Christoph Wirblich et autres

Could new oral vaccine technologies protect endangered wildlife against a rising tide of infectious disease? We used captive chimpanzees to test oral delivery of a rabies virus (RABV) vectored vaccine against Ebola virus (EBOV), a major threat to wild chimpanzees and gorillas. …

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Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1)

Michael J. Fuller, Benoît Callendret, Baogong Zhu, Gordon James Freeman et autres

Hepatitis C virus (HCV) persistence is facilitated by exhaustion of CD8+ T cells that express the inhibitory receptor programmed cell death 1 (PD-1). Blockade of PD-1 signaling improves in vitro proliferation of HCV-specific T lymphocytes, but whether antiviral function can be restored …

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P4‐304: Effects of elevated plasma cholesterol on CSF lipids and Alzheimer's disease CSF biomarkers in African green monkeys

Ikuo Hayashi, Katherine Tugusheva, Peter Szczerba, Dana L. Hasselschwert et autres

Mounting genetic, biochemical and epidemiological evidence suggests that abnormalities in cholesterol metabolism play an important role in the pathogenesis of Alzheimer's disease (AD). It has been previously shown that high-fat/high-cholesterol diet exacerbates brain amyloid burden and memory deficits in amyloid model mice, …

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Transmission of Clonal Hepatitis C Virus Genomes Reveals the Dominant but Transitory Role of CD8+T Cells in Early Viral Evolution

Benoît Callendret, Jens Bukh, Heather B. Eccleston, Ryan A. Heksch et autres

The RNA genome of the hepatitis C virus (HCV) diversifies rapidly during the acute phase of infection, but the selective forces that drive this process remain poorly defined. Here we examined whether Darwinian selection pressure imposed by CD8(+) T cells is a …

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Exhaustion of intra-hepatic CD8+ T cells targeting intact and escaped MHC class I epitopes in chronic phase of hepatitis C virus infection (39.20)

Benoît Callendret, David Geoffrey Bowen, Michael J. Fuller, Heather B. Eccleston et autres

Abstract Hepatitis C virus (HCV)-specific CD8+ T cells persist in the chronically infected liver but provide no apparent control of virus replication. Epitopes targeted by some of these T cells contain escape mutations while others remain intact. Studies in acutely infected humans …

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Selection-Driven Immune Escape Is Not A Significant Factor in the Failure of Cd4 T Cell Responses in Persistent Hepatitis C Virus Infection

Michael J. Fuller, Naglaa H. Shoukry, Toshifumi Gushima, David Geoffrey Bowen et autres

UNLABELLED: Immune escape driven by selection pressure from virus-specific CD8 T cells has been demonstrated in both chimpanzees and humans infected with the hepatitis C virus (HCV). Although escape mutations have also been characterized in major histocompatibility complex (MHC) class II-restricted HCV …

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