Simone Ceccobelli

Correction to: Integrative multi-omics analysis identifies C-type lectin CNVs as functional targets for breeding mastitis-resistant dairy goats

Ying Yuan, He Cong, Tao Ren, Pengcheng Ruan et autres

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Host genetic architecture and gut microbiota cooperatively regulate early growth in goats

Hui‐Long Mou, Zi-Xuan Wang, M Zhang, Liu Y et autres

Early postnatal growth is a critical determinant of meat production efficiency and long-term genetic improvement in goats; however, the molecular mechanisms underlying individual variation in growth performance remain poorly understood. In this study, a total of 123 Hechuan white goats were included. …

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Targeting Myostatin for Sustainable Meat Production: Insights From Multiple Species

Chiara Santomassimo, Francesco Perini, Daniele Colombi, Stefano Bettini et autres

Myostatin gene (MSTN), a TGF-β superfamily member, negatively regulates skeletal muscle growth, positioning it as a prime genetic target for enhancing livestock meat production. This review synthesizes evidence from 1979 to 2025 on MSTN mutations across cattle, pigs, poultry, sheep, goats, and …

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Microencapsulated Functional Additives in Commercial Diets: Effects on Growth, Health, and Intestinal Pro-Inflammatory Gene Expression in Juvenile Rainbow Trout (Oncorhynchus mykiss)

Elena Antonia Belfiore, Federico Conti, Matteo Zarantoniello, Eleonora Spinozzi et autres

Functional feed additives can improve growth, health, and fillet quality in farmed fish, but their stability during feed processing is limited. This study evaluated the effects of dietary microencapsulated rosemary essential oil (REO), astaxanthin (AX), and butyric acid (BA) on growth, oxidative …

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Multi-omics dissection of heat stress reveals CIITA as a central regulator of metabolic thermotolerance in cattle (Bos taurus)

刘承利, Pengcheng Ruan, Zixuan Wang, Yongfu Huang et autres

Climate-driven heat stress disrupts metabolic homeostasis in livestock, yet the molecular mechanisms underlying adaptive responses remain poorly understood. Here, we integrated newly generated plasma metabolomic data from 111 heat-stressed cows with previously published whole-genome sequencing datasets from the same animals, identifying 30 …

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Cross-population analyses between cashmere, angora and non-fibre-producing goats identified signatures of divergent selection

Stefano Pallotti, Simone Ceccobelli, Christian Persichilli, Fabio Pilla et autres

Angora and Cashmere goats differ in hair follicle biology and fibre traits. To explore the genetic basis of these differences, Whole Genome Sequencing (WGS) of Cashmere, Angora, and non-fibre goats were used to identify divergent selection signatures and allele frequency differences. Cross-population …

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Single-cell transcriptomic profiling of goat milk somatic cells highlights immune heterogeneity and epithelial cell-related networks

Tao Ren, Cong He, Ruan Pengcheng, Long Hao-yuan et autres

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Integrative Transcriptomic and Proteomic Analysis Reveals CaMK4-Mediated Regulation of Proliferation in Goat Skeletal Muscle Satellite Cells

He Cong, Yaolong Liu, Zixuan Wang, Tao Ren et autres

CaMK4, a calcium/calmodulin-dependent protein kinase, is an important mediator of cellular signal transduction, yet its role in the regulation of skeletal muscle satellite cells (MuSCs) in goats has remained unclear. In this study, CaMK4 overexpression and knockdown models were established, and integrated …

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Insights into pedigree- and genome-based inbreeding patterns in Martina Franca donkey breed

Vincenzo Landi, Simone Ceccobelli, Stefania Bruno, Claudia Pierini et autres

Conserving small, endangered equine populations demands tools that capture both recent and historical inbreeding more accurately than pedigree alone. The Martina Franca donkey ( MF ), a large indigenous breed from southern Italy that approached extinction in the 1980s, offers a relevant …

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Author Correction: Population structure and identification of genomic regions associated with productive traits in five Italian beef cattle breeds

Daniele Colombi, Giacomo Rovelli, María Gracia Luigi‐Sierra, Simone Ceccobelli et autres

The original version of this Article contained errors. In the Results and discussion section, under the subheading ‘Genome-wide association study for productive traits’,

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Selection Signatures in Italian Goat Populations Sharing the “facciuto” Phenotype

Simona Tarricone, Nikola Schlosserová, Silvia Bruno, Maria Teresa Sardina et autres

Background: The presence of light-pigmented facial stripes, parallel on both sides of the cranial region, is a widespread characteristic in various goat breeds of European origin and beyond. In Italy, this phenotype is relatively common from the north to the south of …

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Genome-Wide Association Integrating a Transcriptomic Meta-Analysis Suggests That Genes Related to Fat Deposition and Muscle Development Are Closely Associated with Growth in Huaxi Cattle

Chengli Liu, Tao Ren, Pengcheng Ruan, Simone Ceccobelli et autres

Growth traits are among the most important economic phenotypes targeted in the genetic improvement of beef cattle. To understand the genetic basis of growth traits in Huaxi cattle, we performed a genome-wide association study (GWAS) on body weight, eye muscle area, and …

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