Hirokazu Wakuda

Forensic implications of ethyl glucuronide and ethyl sulfate pharmacokinetics in Japanese adults: the influence of dose, genetic polymorphisms, and habitual alcohol consumption

Yuko Suefusa-Shimogori, Hirokazu Wakuda, Shin‐ichi Nureki, Megumi Kai et autres

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Correction: Assessing Immunogenicity in Drug Reviews and Prescribing Information in Japan

Mitsuru Ishibai, Megumi Kai, Hirokazu Wakuda, Ichiro Oikawa et autres

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Assessing Immunogenicity in Drug Reviews and Prescribing Information in Japan

Mitsuru Ishibai, Megumi Kai, Hirokazu Wakuda, Ichiro Oikawa et autres

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Flecainide Toxicity From Clinical Pharmacology Perspectives

Naoyuki Otani, Hirokazu Wakuda, Ichiro Oikawa, Naoto Uemura et autres

We report a case comparing the measured half-life of flecainide with the half-life stated on the label. An 84-year-old woman presented with symptoms of anorexia and exertional dyspnea. She had undergone mitral and aortic valve replacements and excision of the membranous septum …

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Completion Report of the Overseas Training Program Awarded by Japanese Society of Clinical Pharmacology and Therapeutics in 2021

Hirokazu Wakuda

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Association between psychomotor function and ALDH2 genotype after consuming barley shochu: A randomized crossover trial

Keiko Matsuura, Satoshi Kushio, Hiromitsu Imai, Hideo Kudo et autres

Sustained exposure to acetaldehyde, the major metabolite of ethanol, may influence psychomotor performance even after the breath ethanol level significantly drops several hours following ethanol consumption. We examined the relationship between psychomotor function and changes in exhaled ethanol and acetaldehyde concentrations after …

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Creating an in vivo hypoxic environment by gas inhalation for the potential evaluation of new pulse oximeters

Naoyuki Otani, Hirokazu Wakuda, Masae Kuranari, Ichiro Oikawa et autres

Pulse oximetry is a noninvasive technique for the continuous monitoring of arterial oxygen saturation using an oximeter, a standard medical device used for assessing respiratory function. The development of pulse oximeters for the production of generic medical devices is expected to continue. …

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Pharmacokinetics of lanoconazole in human skin after repeated topical application

Hiromitsu Imai, Satoru Hashimoto, Ryo Ninomiya, Jingna Luo et autres

Drug disposition after topical application to the skin has not been fully elucidated, especially after repeated application. We conducted a clinical trial to evaluate the pharmacokinetics in the stratum corneum of healthy adults after repeated application of lanoconazole cream as a model …

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Scientific misconduct in sponsored clinical trials in Japan: published cases are the “tip of the iceberg”

Kiyomi HIRAYAMA, Masae Kuranari, Hirokazu Wakuda, Naoyuki Otani et autres

Although cases of research misconduct in sponsored clinical trials have been sporadically reported, no systematic reviews or national surveys on this topic have been conducted in Japan. Thus, this study aimed to: 1) systemically review publicly available information on scientific misconduct reported …

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