Keiko Matsuura

Tumorigenesis of Hepatocellular Carcinoma Related to Metabolic Disorders With a Focus on the Hippo Pathway

Haruto Nishida, Keiko Matsuura, Tsutomu Daa

The Hippo pathway has been implicated in the tumorigenesis of hepatocellular carcinoma (HCC). We aimed to determine the expression of Hippo pathway-related proteins in HCC using immunohistochemical staining and compare the data among patients with different underlying clinical background diseases. We collected …

jp (code pays fourni par la source)

Water intake during drinking does not alleviate hangover symptoms

Hiromitsu Imai, Satoshi Kushio, Keiko Matsuura, Akihiro Nakamura et autres

Background: Hangovers can impair the ability to drive a car or work in industrial settings, in addition to causing unpleasant symptoms such as headaches and fatigue. As for reducing hangover symptoms, the effect of consuming water between drinks, often referred to as …

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High-effect synergy from dual HDAC6 and YAP–TEAD inhibition in ovarian clear cell carcinoma

Sumika Zaitsu, Mitsutake Yano, Sohei Sakashita, Maiko Miwa et autres

BACKGROUND: Ovarian clear cell carcinoma (OCCC) is an aggressive epithelial subtype characterized by intrinsic chemoresistance and limited targeted therapies. Transcriptional programs driven by Yes-associated protein (YAP) and TEA domain (TEAD) factors support tumor stress adaptation, suggesting that this axis represents therapeutic vulnerability. …

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Lipid droplet distribution quantification method based on lipid droplet detection by constrained reinforcement learning

Yoshitomi Harada, Haruto Nishida, Keiko Matsuura

We previously proposed the lipid droplet detection by reinforcement learning (LiDRL) method using a limited dataset of pathological images. The method automatically detects lipid droplets using reinforcement learning to optimize filter combinations based on their size and grayscale contrast. In this study, …

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Metabolic dynamics of human external urethral sphincter myoblast differentiation and the effects of tricarboxylic acid cycle inhibition

Shinro Hata, Noriko Hamamatsu, Mayuka Shinohara, Keiko Matsuura et autres

Stress urinary incontinence commonly arises with aging or following prostatectomy, yet its underlying mechanisms remain unclear. To address this, we investigated the role of metabolic pathways-particularly the tricarboxylic acid (TCA) cycle-in the differentiation of human external urethral sphincter myoblasts. Immortalized sphincter cells …

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Metabolic Dynamics of Human External Urethral Sphincter Myoblast Differentiation and the Effects of Tricarboxylic Acid Cycle Inhibition

Shinro Hata, Noriko Hamamatsu, Mayuka Shinohara, Keiko Matsuura et autres

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Exploring the Replication and Pathogenic Characteristics of Alpha, Delta, and Omicron Variants of SARS-CoV-2

Sakirul Khan, Takaaki Yahiro, Kazunori Kimitsuki, Takehiro Hashimoto et autres

The variants of concern (VOCs) of SARS-CoV-2 have exhibited different phenotypic characteristics in clinical settings which are yet to be fully explored. This study aimed to characterize the viral replication features of major VOCs of SARS-CoV-2 and their association with pathogenicity. The …

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Lipid droplet detection in histopathological images using reinforcement learning

Yoshitomi Harada, Haruto Nishida, Keiko Matsuura

The identification and analysis of lipid droplets in pathological images are pivotal owing to the variations in their size, shading and shape. The development of an artificial intelligence-based automatic detection method can facilitate the analysis of complex pathological images and provide essential …

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Novel insight into the genetic diversity of strongylid nematodes infecting South-East and East Asian primates

Bethan Mason, Barbora Červená, Liesbeth Frías, Benoît Goossens et autres

Abstract With many non-human primates (NHPs) showing continued population decline, there is an ongoing need to better understand their ecology and conservation threats. One such threat is the risk of disease, with various bacterial, viral and parasitic infections previously reported to have …

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Association between psychomotor function and ALDH2 genotype after consuming barley shochu: A randomized crossover trial

Keiko Matsuura, Satoshi Kushio, Hiromitsu Imai, Hideo Kudo et autres

Sustained exposure to acetaldehyde, the major metabolite of ethanol, may influence psychomotor performance even after the breath ethanol level significantly drops several hours following ethanol consumption. We examined the relationship between psychomotor function and changes in exhaled ethanol and acetaldehyde concentrations after …

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Developmental Stages of Grassenema procaviae Petter, 1959 (Cosmocercoidea: Atractidae) Found in the Stomach of Cape Hyrax (Procavia capensis)

Hideo Hasegawa, Kei Hayashi, Yuko Akita, Yumi Une et autres

Morphological examination was made of the larval forms of Grassenema procaviae (Cosmocercoidea: Atractidae), an autoinfective and viviparous nematode parasite in the stomach of Cape hyrax (Procavia capensis). Three different larval stages (second-, third- and fourth-stages), and the adult stage were found among …

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Notes on Morphology and Life History of Probstmayria gombensis (Nematoda: Cosmocercoidea: Atractidae), Parasitic in Eastern Chimpanzees, Pan troglodytes schweinfurthii, in Bulindi, Uganda

Hideo Hasegawa, Matthew R. McLennan, Michael A. Huffman, Keiko Matsuura

Probstmayria gombensis File, 1976 (Nematoda: Cosmocercoidea: Atractidae) individuals discharged in the feces of eastern chimpanzees, Pan troglodytes schweinfurthii, in Bulindi, Uganda, were examined morphologically. Adults and fourth-stage larvae, all females, found in the feces, and the third-stage larvae excised from the uterus …

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