Huijeong Choi

Diazo-6Bx, a Six-Branched Diazo Cross-Linker, Enables High-Fidelity Patterning for Solution-Processed Electronics with Stable Operation

Hyobin Ham, In Cheol Kwak, Daeyeon Lee, Seongjae Lee et autres

Direct photopatterning with photoactivated cross-linkers provides a powerful route to highly integrated, solution-processed electronics. We introduce Diazo-6Bx, a six-branched diazo-based cross-linker that combines high miscibility with organic semiconductors and efficient C-H insertion reactivity. Comparative studies with azide-functionalized cross-linkers (phenyl- and tetrafluorophenyl-based structural …

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Fluorinated Asymmetric 2D Core-Extended Nonfullerene Acceptors for Efficient Organic Solar Cells

Peddaboodi Gopikrishna, Huijeong Choi, Do Hui Kim, Heunjeong Lee et autres

Organic solar cell efficiency can be boosted through the strategic extension of the 2D conjugated core in nonfullerene acceptors (NFAs). In this work, two NFAs, IC-IQ2FDMBO-IC and IC2F-IQ2FDMBO-IC2F, were synthesized based on an asymmetric, fluorinated 2D-extended quinoxaline core featuring an unexpected N,N …

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Microneedle Patch Loaded with Metabolized Elastin-Complexed Ceria Nanoparticles for Oral Ulcer Treatment

Yun‐Jung Lee, Sungjae Yoo, Sang-Chul Kwon, Jae‐Seon Lee et autres

Oral ulcers are prevalent oral health issues with a high recurrence rate that substantially impair oral and systemic health. However, current therapies for oral ulcers are limited to symptom relief without addressing its fundamental pathophysiology. Additionally, their treatment efficacy is limited by …

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Loop structure in poly(A) tail of mRNA vaccine enhances antigen translation efficiency and mRNA stability

Ayoung Oh, Seonghyun Lee, Hyeong-Jun Park, Subin Yoon et autres

As mRNA technology emerges as a groundbreaking innovation, an increasing number of studies are attempting to increase expression levels by optimizing the structure of mRNA, such as the 5' or 3' untranslated regions (UTR). We designed a novel loop structure in the …

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Impact of Quinoxaline Units in Random Terpolymers on Enhancing Indoor Organic Photovoltaics: Lowering HOMO Level and Improving Miscibility

Huijeong Choi, Gyeong Min Lee, Muhammad Ahsan Saeed, Gayoung Ham et autres

The rapid growth in demand for the Internet of Things (IoT) has increased the need for power sources capable of harvesting energy from indoor light sources. Indoor organic photovoltaics (IOPVs) have emerged as promising candidates due to their ability to effectively harness …

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Effective mRNA-based therapy using E7 antigen and IL-12 cytokine in head and neck cancer mice models

Seonghyun Lee, Jisun Lee, Yu‐Sun Lee, Sowon Lee et autres

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Rapid‐Turnaround Co‐Administration of mRNA‐Based MHC‐I and MHC‐II‐Restricted Neoantigens Enhances Immune Responses of Antigen‐Specific CD8 + T Cells and Anti‐Cancer Efficacy in Colorectal Cancer

Seongje Cho, Woori Kwak, Hyunho Yoon, Jisun Lee et autres

Abstract Personalized cancer vaccines (PCVs) represent a promising frontier in cancer immunotherapy; however, challenges in neoantigen prediction and treatment optimization persist. This study aims to introduce an innovative mRNA‐based PCV platform that addresses these limitations. Co‐administration of our major histocompatibility complex (MHC)‐I …

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Rational Design of Lipid Nanoparticles for Enhanced mRNA Vaccine Delivery via Machine Learning (Small 8/2025)

Seo‐Hyeon Bae, Hosam Choi, Jisun Lee, Min‐Ho Kang et autres

Lipid Nanoparticles An innovative integration of artificial intelligence (AI) with in-vivo experiments of mRNA delivery and expression for optimizing the lipid nanoparticles (LNPs) structure. The AI-driven in-silico models, represented by AI mice, enabled the identification of key chemical structures guiding the selection …

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Impact of Quinoxaline Units in Random Terpolymers on Enhancing Indoor Organic Photovoltaics: Lowering Homo Level and Improving Miscibility

Huijeong Choi, Gyeong Min Lee, Junmo Kang, Muhammad Ahsan Saeed et autres

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Rational Design of Lipid Nanoparticles for Enhanced mRNA Vaccine Delivery via Machine Learning

Seo‐Hyeon Bae, Hosam Choi, Jisun Lee, Min‐Ho Kang et autres

Since the coronavirus pandemic, mRNA vaccines have revolutionized the field of vaccinology. Lipid nanoparticles (LNPs) are proposed to enhance mRNA delivery efficiency; however, their design is suboptimal. Here, a rational method for designing LNPs is explored, focusing on the ionizable lipid composition …

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Halogenated 9H‐Indeno[1,2‐b]Pyrazine‐2,3‐Dicarbonitrile End Groups Based Asymmetric Non‐Fullerene Acceptors for Green Solvent‐Processable, Additive‐Free, and Stable Organic Solar Cells

Peddaboodi Gopikrishna, Huijeong Choi, Do Hui Kim, Dong‐Chan Lee et autres

Non-fullerene acceptors (NFAs) significantly enhance photovoltaic performance in organic solar cells (OSCs) using halogenated solvents and additives. However, these solvents are environmentally detrimental and unsuitable for industrial-scale production, and the issue of OSCs' poor long-term stability persists. This report introduces eight asymmetric …

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Trifluoromethyl-substituted asymmetric non-fullerene acceptors enable non-halogenated solvent-processed indoor organic photovoltaics with an efficiency of over 30%

Peddaboodi Gopikrishna, Muhammad Ahsan Saeed, SungHyun Hur, Gyeong Min Lee et autres

Four asymmetric non-fullerene acceptors were synthesized. Additive-free, non-halogen solvent-processed indoor organic photovoltaics achieved efficiencies of 27.1% and 30.2% under 1000 lux LED and fluorescent light, respectively.

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