Carmen P. Wong

The Gut Microbiome and Diet Interact to Dictate Personalized Response to Broccoli Sprout Consumption

Alexandra Alexiev, Laura M. Beaver, John A. Bouranis, Carmen P. Wong et autres

ABSTRACT Broccoli sprouts produce sulforaphane (SFN), a dietary isothiocyanate with anti‐cancer and anti‐inflammatory properties. Human intervention trials observe large variation in metabolite generation and bioactivity with broccoli sprout consumption across individuals. We hypothesize that interactions between pre‐intervention diet and personalized gut microbiome …

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Almond Consumption Shifts Gut Microbiota Composition and Oxylipin Profiles to Improve Cardiometabolic Health in Participants With Metabolic Syndrome

Emily Ho, Mahak Hosseinika, Laura M. Beaver, Edward W. Davis et autres

Objectives: Intestinal dysbiosis can contribute to the progression of metabolic syndrome and affect the risk of cardiometabolic diseases, especially in people consuming poor diets. Almonds are a rich dietary source of bioactive food components such as fiber, micronutrients, polyphenols and unsaturated fatty …

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Preconception metabolic-bariatric surgery and child health outcomes: Identification and cohort profile of the POSIT study protocol

Jonathan Q. Purnell, Darios Getahun, Kimberly K. Vesco, Sijia Qiu et autres

Abstract Preconception weight loss by metabolic-bariatric surgery (MBS) improves maternal-fetal outcomes, but little is known about its impact on offspring growth and health. The preconception bariatric surgery and child health outcomes (POSIT) study aims to estimate the effects of maternal MBS-induced preconception …

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Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station - white adipose tissue (WAT) data

Carmen P. Wong, Urszula T. Iwaniec, Russell T. Turner

Sixteen-week-old female C57BL/6J mice were sacrificed aboard the International Space Station after 37 days of flight (RR-1 mission) and frozen carcasses returned to Earth. RNA was isolated from interscapular brown adipose tissue (BAT) and gonadal white adipose tissue (WAT). Spaceflight resulted in …

Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station - brown adipose tissue (BAT) data

Carmen P. Wong, Urszula T. Iwaniec, Russell T. Turner

Sixteen-week-old female C57BL/6J mice were sacrificed aboard the International Space Station after 37 days of flight (RR-1 mission) and frozen carcasses returned to Earth. RNA was isolated from interscapular brown adipose tissue (BAT) and gonadal white adipose tissue (WAT). Spaceflight resulted in …

Introduction of Mature Mast Cells into Bone Marrow Alters Bone Metabolism in Growing Mice

Carmen P. Wong, Jessica Keune, Kenneth A. Philbrick, Adam J. Branscum et autres

There is evidence that mast cells contribute to skeletal response to injury, but it is less clear whether these immune cells directly influence normal bone growth and turnover. Mature mast cells are common in the bone marrow of humans and rats, but …

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Cruciferous Vegetables, Bioactive Metabolites, and Microbiome for Breast Cancer Prevention

Emily Ho, Carmen P. Wong, John A. Bouranis, Jackilen Shannon et autres

Breast cancer is a heterogeneous disease with varying subtypes, prognoses, and treatment responses. Cruciferous vegetables have shown promise in reducing breast cancer risk. This review discusses ( a ) the efficacy of sulforaphane (SFN) and indole-3-carbinol (I3C)/3,3′-diindolylmethane (DIM) on breast cancer risk, …

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Protective role of dietary zinc on DNA damage, oxidative stress, and metal toxicity

Carmen P. Wong, Laura M. Beaver, Emily Ho

Dr. Bruce Ames illustrious career spanned many decades with far-reaching impacts both on our knowledge of DNA and in public health. In the 1990s he explored the connection between inadequate intake of micronutrients and single- and double-strand DNA breaks, genome instability due …

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Adoptive Transfer of Lepr+ Bone Marrow Cells Attenuates the Osteopetrotic Phenotype of db/db Mice

Russell T. Turner, Carmen P. Wong, Kenneth A. Philbrick, Jessica Keune et autres

Leptin-deficient (ob/ob) and leptin receptor (Lepr)-deficient db/db mice develop a mild form of osteoclast-rich osteopetrosis, most evident in long bone epiphyses, implying leptin is important for normal replacement of cartilage during skeletal maturation. However, it is unclear whether leptin acts as a …

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Combinatorial Effects of Zinc Status and Aging on Bone in Male Mice

Laura M. Beaver, Carmen P. Wong, Emily Ho, Adam J. Branscum et autres

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Beneficial Changes in Total and LDL-Cholesterol, Gut Health Parameters, and Vitamin E Status in Adults With Metabolic Syndrome Consuming Almonds as Snacks

Laura M. Beaver, Scott W. Leonard, Sandra L. Uesugi, Carmen P. Wong et autres

Objectives: Poor gut health and chronic inflammation contribute to the progression of metabolic syndrome and affect the development of cardiometabolic diseases, especially in persons consuming diets with limited bioactive compounds. Almonds are a rich source of bioactive compounds with antioxidant and anti-inflammatory …

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Beneficial changes in total cholesterol, LDL-C, biomarkers of intestinal inflammation, and vitamin E status in adults with metabolic syndrome consuming almonds as snack foods: a randomized controlled clinical trial

Laura M. Beaver, Scott W. Leonard, Sandra L. Uesugi, Carmen P. Wong et autres

• A daily snack of almonds benefited people with metabolic syndrome. • Almond snacking improved gut inflammation biomarkers. • Almond snacking increased α-tocopherol, soluble fiber, copper, magnesium intakes. • Almond snacking improved plasma α-tocopherol/cholesterol ratio. • Almond snacking improved low-density lipoprotein and …

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