Yi Wolf Zhang

Assessing the impact of the Inflation Reduction Act on Medicare prescription drug coverage

Yi Wolf Zhang, Michael G. Blyumin, Cori Qu, Xu Guo et autres

PURPOSE: The Inflation Reduction Act (IRA) introduced significant reforms to Medicare Part D in 2025, aiming to reduce medication costs for beneficiaries by eliminating the coverage gap ("donut hole") with a $2,000 annual out-of-pocket cap. However, insurers' responses to these policy reforms-and …

us (code pays fourni par la source)

Assessing the Impact of the Inflation Reduction Act on Medicare Prescription Drug Coverage

Yi Wolf Zhang, Michael G. Blyumin, Chongbing Qu, Xuhong Guo et autres

Abstracts Importance The Inflation Reduction Act (IRA) introduced significant reforms to Medicare Part D in 2025, aiming to reduce medication costs for beneficiaries by eliminating the coverage gap (“donut hole”) with a $2,000 annual out-of-pocket cap. However, insurers’ responses to these policy …

us (code pays fourni par la source)

Omniligase-1-Mediated Phage-Peptide Library Modification and Insulin Engineering

Yi Wolf Zhang, Nai-Pin Lin, Xu Guo, Nicolas Szabo‐Fresnais et autres

Chemical and enzymatic modifications of peptide-displayed libraries have been successfully employed to expand the phage display library. However, the requirement of specific epitopes and scaffolds has limited the scope of protein engineering using phage display. In this study, we present a novel …

us (code pays fourni par la source)

Supramolecular approaches for insulin stabilization without prolonged duration of action

Rolande Meudom, Yanxian Zhang, Michael A. VandenBerg, Lei Zou et autres

Aggregation represents a significant challenge for the long-term formulation stability of insulin therapeutics. The supramolecular PEGylation of insulin with conjugates of cucurbit[7]uril and polyethylene glycol (CB[7]‒PEG) has been shown to stabilize insulin formulations by reducing aggregation propensity. Yet prolonged in vivo duration …

us (code pays fourni par la source)

Serine-mediated hydrazone ligation displaying insulin-like peptides on M13 phage pIII

Yi Wolf Zhang, Nan Zheng, Danny Hung‐Chieh Chou

Phage display has emerged as a tool for the discovery of therapeutic antibodies and proteins. However, the effective display and engineering of structurally complex proteins, such as insulin, pose significant challenges due to the sequence of insulin, which is composed of two …

us (code pays fourni par la source)

Suboptimal antimicrobial discharge prescriptions at a tertiary referral children’s hospital

Yi Wolf Zhang, Sruti Paturi, Lauren M. Puckett, David Scheinker et autres

Objective: To determine the rate of and factors associated with suboptimal discharge antimicrobial prescribing at a tertiary referral children's hospital. Design: Retrospective cohort. Setting: Tertiary referral children's hospital. Population: All enteral antimicrobial discharge prescriptions at Lucile Packard Children's Hospital Stanford from January …

us (code pays fourni par la source)

Synthesis and Characterization of Phenylboronic Acid-Modified Insulin With Glucose-Dependent Solubility

Nai-Pin Lin, Nan Zheng, Landa Purushottam, Yi Wolf Zhang et autres

Glucose-responsive insulin represents a promising approach to regulate blood glucose levels. We previously showed that attaching two fluorophenylboronic acid (FPBA) residues to the C-terminal B chain of insulin glargine led to glucose-dependent solubility. Herein, we demonstrated that relocating FPBA from B chain …

us (code pays fourni par la source)

Symmetric and asymmetric receptor conformation continuum induced by a new insulin

Xiaochun Xiong, Alan Blakely, Jin Hwan Kim, John G. T. Menting et autres

us, au, de, dk (code pays fourni par la source)

Omniligase-1-mediated ligation for insulin analog synthesis in solu-tion and on phage surface

Nai-Pin Lin, Yi Wolf Zhang, Nicolas Szabo‐Fresnais, Danny Hung‐Chieh Chou

The B-chain C-terminal region of insulin has been mutated or modified to achieve improved therapeutic efficacies. For ex-ample, all FDA-approved insulin analogs have altered C-terminal segments, which leads to improved pharmacokinetic prop-erties and provide significant clinical benefits on blood sugar regulation. Nonetheless, …

us (code pays fourni par la source)

Omniligase-1-mediated ligation for insulin analog synthesis in solu-tion and on phage surface

Nai-Pin Lin, Yi Wolf Zhang, Nicolas Szabo‐Fresnais, Danny Hung‐Chieh Chou

The B-chain C-terminal region of insulin has been mutated or modified to achieve improved therapeutic efficacies. For ex-ample, all FDA-approved insulin analogs have altered C-terminal segments, which leads to improved pharmacokinetic prop-erties and provide significant clinical benefits on blood sugar regulation. Nonetheless, …

us (code pays fourni par la source)

Omniligase-1-mediated ligation for insulin analog synthesis in solu-tion and on phage surface

Danny Hung‐Chieh Chou, Nai-Pin Lin, Yi Wolf Zhang, Nicolas Szabo‐Fresnais

The B-chain C-terminal region of insulin has been mutated or modified to achieve improved therapeutic efficacies. For ex-ample, all FDA-approved insulin analogs have altered C-terminal segments, which leads to improved pharmacokinetic prop-erties and provide significant clinical benefits on blood sugar regulation. Nonetheless, …

us (code pays fourni par la source)

Omniligase-1-mediated ligation for insulin analog synthesis in solu-tion and on phage surface

Danny Hung‐Chieh Chou, Nai-Pin Lin, Yi Wolf Zhang, Nicolas Szabo‐Fresnais

The B-chain C-terminal region of insulin has been mutated or modified to achieve improved therapeutic efficacies. For ex-ample, all FDA-approved insulin analogs have altered C-terminal segments, which leads to improved pharmacokinetic prop-erties and provide significant clinical benefits on blood sugar regulation. Nonetheless, …

us (code pays fourni par la source)