Lauren M. Puckett

Successful Implementation of Nirsevimab and Factors Influencing Uptake in Neonatal Care

Lauren M. Puckett, Lauren E. Kushner, Laura L. Bio, Sean Cornell et autres

OBJECTIVE: To describe the implementation of nirsevimab for the prevention of respiratory syncytial virus-associated lower respiratory tract disease in a pediatric hospital, focusing on strategies to ensure equitable access and address logistic challenges. Additionally, we aimed to identify predictors of nirsevimab deferral …

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Utilization of Hepatitis C Virus‐Infected Donor Hearts in Two Children and Two Young Adults: Initial Experience at a Pediatric Transplant Center

Lauren E. Kushner, Lauren M. Puckett, Joanne Lee, Hayley A. Gans et autres

BACKGROUND: Although adult transplant centers are successfully transplanting organs from hepatitis C virus (HCV)-infected donors with detectable viral load by nucleic acid testing (NAT+) into HCV-negative recipients, this practice has not yet been adopted widely by the pediatric heart transplant community. METHODS: …

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Outpatient parenteral antimicrobial therapy in pediatrics: the role of antimicrobial stewardship

Daniel J Trisno, Lauren M. Puckett, Alexandria M. Jensen, Hayden T. Schwenk

This study characterized outpatient parenteral antimicrobial therapy (OPAT) orders and associated antimicrobial stewardship program (ASP) pharmacist recommendations made in a freestanding children's hospital. Recommendations occurred in over 50% of orders, indicating an opportunity for the review of OPAT by ASP pharmacists.

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2945. Audit and Feedback Informed ASP Interventions Lead to Sustained Reductions in Suboptimal Antibiotic Prescribing at Hospital Discharge

Lauren M. Puckett, Laura L. Bio, Sean Cornell, Hayden T. Schwenk

Abstract Background Antimicrobial stewardship programs (ASPs) have traditionally focused on the inpatient setting; however, a significant proportion of antibiotics initiated during hospital stays are continued at the time of discharge. Previous studies have found that rates of suboptimal antibiotic prescribing at the …

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Suboptimal antimicrobial discharge prescriptions at a tertiary referral children’s hospital

Yi Wolf Zhang, Sruti Paturi, Lauren M. Puckett, David Scheinker et autres

Objective: To determine the rate of and factors associated with suboptimal discharge antimicrobial prescribing at a tertiary referral children's hospital. Design: Retrospective cohort. Setting: Tertiary referral children's hospital. Population: All enteral antimicrobial discharge prescriptions at Lucile Packard Children's Hospital Stanford from January …

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949. Impact of Antimicrobial Stewardship Pharmacist Participation in Pediatric Infectious Diseases Rounds on Prospective Audit and Feedback Recommendations

Laura L. Bio, Lauren M. Puckett, Torsten A. Joerger, Hayden T. Schwenk

Abstract Background Prospective audit and feedback (PAF) is a core strategy of antimicrobial stewardship programs (ASPs). To improve communication of PAF recommendations to the inpatient pediatric infectious diseases (ID) consult service, the ASP pharmacists at our hospital were integrated into ID rounds. …

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Successful nasoenteric administration of glecaprevir/pibrentasvir for donor‐derived hepatitis C in two young adult heart transplant recipients at a pediatric transplant center

Lauren E. Kushner, Lauren M. Puckett, Joanne Lee, Torsten A. Joerger et autres

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Leveraging antimicrobial stewardship programs in response to the coronavirus disease 2019 (COVID-19) public health emergency

Torsten A. Joerger, Laura L. Bio, Lauren M. Puckett, Hayden T. Schwenk

The coronavirus disease 2019 (COVID-19) pandemic has strained antimicrobial stewardship programs (ASPs) but offered new opportunities. This review summarizes the impact of the COVID-19 pandemic on ASPs, review the contributions ASPs have made in the pandemic response, and highlight the potential role …

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159. Characterization of Suboptimal Discharge Antimicrobial Prescriptions and Effect of Inpatient Audit and Feedback on Quality of Antimicrobial Prescribing

Lauren M. Puckett, Laura L. Bio, Sean Cornell, Torsten A. Joerger et autres

Abstract Background Approximately 30% of children are discharged from the hospital with an antimicrobial prescription; nearly a third of these prescriptions are suboptimal. Although the best approach to antimicrobial stewardship of discharge prescriptions remains uncertain, prospective audit and feedback (PAF) has improved …

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Impact of Direct From Blood Culture Identification of Pathogens Paired With Antimicrobial Stewardship Interventions in a Pediatric Hospital

Lauren M. Puckett, Poonam Rajkotia, Lisa Coppola, Lori Baumgartner et autres

OBJECTIVE Identification of organisms directly from positive blood culture by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has the potential for improved clinical outcomes through earlier organism identification and shorter time to appropriate clinical intervention. The uses of this technology in …

Advancing pediatric antimicrobial stewardship: Has pharmacodynamic dosing for gram-negative infections taken effect?

Lauren M. Puckett, Jason G. Newland, Jennifer Ellis Girotto

Objective: To characterize pharmacodynamic dosing strategies used at children's hospitals using a national survey. Design: Survey. Setting: Children's hospitals. Participants: Volunteer sample of antimicrobial stewardship program (ASP) respondents. Methods: A nationwide survey was conducted to gain greater insight into the current adoption …

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