Jeryn Chang

Multimodal ultra-high-field MRI, clinical, cognitive, and genetic profiles across the ALS–FTD spectrum

Thomas B. Shaw, Aiman Al Najjar, Markus Barth, Steffen Bollmann et autres

This dataset was acquired and curated to explore the spectrum of Motor Neuron Disease (MND) and Fronto-Temporal Dementia (FTD) with Ultra-High Field Magnetic Resonance Imaging (7 Tesla) and compare these to non-neurodegenerative disease controls (known colloquially as "The 7 T hEalthy Ageing …

au, us, at (code pays fourni par la source)

Multimodal ultra-high-field MRI, clinical, cognitive, and genetic profiles across the ALS–FTD spectrum.

Thomas Shaw, Aiman al Najjar, Markus Barth, Steffen Bollmann et autres

N/A

Multimodal ultra-high-field MRI, clinical, cognitive, and genetic profiles across the ALS–FTD spectrum.

Thomas Shaw, Aiman al Najjar, Markus Barth, Steffen Bollmann et autres

N/A

Multimodal ultra-high-field MRI, clinical, cognitive, and genetic profiles across the ALS–FTD spectrum.

Thomas Shaw, Aiman al Najjar, Markus Barth, Steffen Bollmann et autres

N/A

A multimodal investigation of hypothalamic and multisystem contributions to appetite dysregulation in motor neuron disease

Jeryn Chang

White matter changes in reward circuits of amyotrophic lateral sclerosis: a fixel-based study of appetite loss

Jeryn Chang, Harry Lipscombe, Jinglei Lv, Pamela A. McCombe et autres

BACKGROUND: Non-motor symptoms such as appetite loss contribute to weight and fat mass reduction in people living with Amyotrophic Lateral Sclerosis (plwALS), both of which are strong prognostic factors in the disease. Consequently, understanding the neural mechanisms underlying appetite and other non-motor …

au (code pays fourni par la source)

Multimodal ultra-high-field MRI, clinical, cognitive, and genetic profiles across the ALS–FTD spectrum.

Thomas Shaw, Aiman al Najjar, Markus Barth, Steffen Bollmann et autres

N/A

Segmentation of the human tongue musculature using MRI: Field guide and validation in motor neuron disease

Thomas B. Shaw, Fernanda Lenita Ribeiro, Patrick Aiken, Saskia Bollmann et autres

This work addresses the challenge of reliably measuring the muscles of the human tongue, which are difficult to quantify due to complex interwoven muscle types. We introduce a new semi-automated method, enabled by a manually curated dataset of MRI scans to accurately …

au, gb (code pays fourni par la source)

Deciphering hypothalamic pathology in ALS: insights into non-motor symptoms and disease progression

Jeryn Chang, A. Teo, Thomas B. Shaw, Luc Dupuis et autres

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with highly heterogeneous clinical presentations. Among the non-motor features increasingly recognised as clinically relevant is the dysregulation of energy balance, with weight loss-particularly due to fat mass loss-emerging as a significant modifier of …

au, fr (code pays fourni par la source)

An fMRI dataset for appetite neural correlates in people living with Motor Neuron Disease

Jeryn Chang, Jinglei Lv, Christine Cong Guo, Diana Lucia et autres

The dataset investigates the neural correlates of appetite in people living with motor neuron disease (plwMND) compared to non-neurodegenerative disease controls. Thirty-six plwMND and twenty-three controls underwent two fMRI sessions: one in a fasted state and one postprandial. Participants viewed visual stimuli …

au (code pays fourni par la source)

Appetite loss in patients with motor neuron disease: impact on weight loss and neural correlates of visual food cues

Jeryn Chang, Thomas B. Shaw, Pamela McCombe, Robert D. Henderson et autres

Abstract Motor Neuron Disease (MND) is associated with significant non-motor symptoms, including the loss of appetite. Loss of appetite has emerged as a dominant feature of the disease that may contribute to negative energy balance, faster disease progression and earlier death. We …

au, sg (code pays fourni par la source)

Long-term fixation impact on archived human nervous tissues for sequencing-based transcriptomics

Stephanie M. Howe, Heather McCann, Zherui Xiong, Quan Nguyen et autres

The advent of transcriptomics technologies compatible with formalin-fixed paraffin-embedded tissues has enabled greater opportunities for scientists to interrogate the transcriptome of archived tissues, especially those from rare neurodegenerative diseases. Tissues from brain banks are often placed in fixative for weeks or years …

au (code pays fourni par la source)