Thomas Misgeld

MassIVE MSV000102814 - Optineurin-dependent checkpoints regulate mitochondrial turnover at synapses

Thomas Misgeld

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MassIVE MSV000102758 - Neuronal compartmentalization results in "minimalist" axonal mitochondria

Thomas Misgeld

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A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes

Julien Klimmt, Carolina Cardoso Gonçalves, Jessica Valentina Montgomery, Stephan A. Müller et autres

Stem-cell-based in vitro models offer promising potential to elucidate human brain cell functions and interactions, but limitations in reproducibility, maturation and cell-type diversity persist. Especially, prolonged incorporation of mature microglia and studies of neuroinflammation have proven challenging. Here, we developed a human …

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Focal astrocyte loss reveals nuclear translocation during lesion repopulation

Marina Herwerth, Matthias T. Wyss, Nicola B. Schmid, Anna Lasne et autres

Astrocyte loss occurs in various neurological conditions and can disrupt local tissue homeostasis. While astrocytes surrounding border-forming lesions adopt reactive states without restoring astrocyte networks, how astrocytes respond to spatially confined astrocyte loss remains poorly understood. Here we used longitudinal in vivo …

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Early demyelination by off-target complement injury in a mouse model of neuromyelitis optica

Selin Kenet, Marina Herwerth, Shahrzad Askari, Katharina Eichenseer et autres

Abstract Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune CNS disease characterized by serum antibodies targeting astrocytes for complement-mediated lysis. NMOSD lesions show not only astrocyte loss but also early demyelination and oligodendrocyte injury – histological hallmarks that converge with those of …

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Selective Cortical Myelination Reflects Axon-Driven Progression of the BCAS1-positive Oligodendrocyte Lineage

Zi Ling Huang, Alexander Goldbrunner, Shahrzad Askari, Katharina Eichenseer et autres

Abstract Myelination in the cerebral cortex is sparse, discontinuous, showing marked heterogeneity across cortical areas and along individual axons, yet the mechanisms that establish this complex and selective architecture remain unclear. Using histological mapping of oligodendrocyte lineage cells across cortical areas combined …

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Local demyelination rekindles oligodendrocyte precursor dynamics and remyelination in old age

Katharina Eichenseer, Shahrzad Askari, Llazar Shkurti, Thomas Misgeld et autres

Abstract Cortical myelination is critical for circuit function, plasticity, and long-term stability in the adult brain. With age and disease, the capacity to restore myelin after oligodendrocyte (OL) loss declines, and this failure is thought to reflect intrinsic limitations of OL precursor …

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Fuelling the brain with calcium

Adrián Martí Pastor, Y. I. Tai, Thomas Misgeld

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A reproducible human brain tissue model to study physiological and disease-associated microglia phenotypes

Julien Klimmt, Carolina Cardoso Gonçalves, Jessica Valentina Montgomery, Stephan A. Müller et autres

Abstract Stem-cell-based in vitro models offer promising potential to elucidate human brain cell functions and interactions under physiological and pathological conditions. However, harnessing this potential is impaired by low reproducibility, maturity, or cell-type diversity of existing models. Especially, prolonged incorporation of mature …

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Mitochondrial hitch-hiking of Mapt mRNA maintains Tau levels in axons

Hariharan Murali Mahadevan, Ayat E. Rehailia, Adrián Martí Pastor, Isabel M.C. Geelhaar et autres

Abstract Hitch-hiking of transcripts on organelles, including mitochondria, has emerged as a common pathway to transport mRNAs into the axon to enable their local translation. However, the extent of mitochondrial mRNA association in vivo has not been established. Here we report the …

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Fuelling the brain with calcium.

Adrian Marti Pastor, Y. I. Tai, Thomas Misgeld

Complement C4d Informs the Differential Diagnosis of Inflammatory Demyelinating CNS Diseases

Carolin Landt, Friederike Held, Konstantina Kolotourou, Mihaela Guranda et autres

BACKGROUND AND OBJECTIVES: Complement-targeting therapies are pivotal in managing neuromyelitis optica spectrum disorder (NMOSD), calling for a deeper understanding of complement activation across idiopathic inflammatory demyelinating diseases (IIDDs) of the CNS. C4d, a covalently bound complement split product, offers prolonged detectability at …

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