Pierfilippo Crucitti

Primary Low‐Grade Fibromyxoid Sarcoma of the Left Upper Lobe Treated With Uniportal Video‐Assisted Thoracoscopic Lobectomy

Giovanni Tacchi, Luca Frasca, Filippo Longo, Ilaria Suriano et autres

Low-grade fibromyxoid sarcoma (LGFMS) is a rare tumor that usually affects young adults and arises on the proximal extremities and trunk. Primary pulmonary LGFMS is an extremely rare entity. We reported a postsurgical diagnosis of a primary lung LGFMS in a patient …

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The role of tumor dimension among the different thymic tumor histologies: A European Society of Thoracic Surgeons thymic database analysis

Marco Chiappetta, Filippo Lococo, Teresa Ferrazzo, Bernhard Moser et autres

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Vagus nerve management in lung cancer surgery: anatomical preservation, functional modulation and postoperative outcomes—a narrative review

Ilaria Suriano, Luca Frasca, Antonio Sarubbi, Filippo Longo et autres

BACKGROUND AND OBJECTIVE: The vagus nerve plays a fundamental role in regulating bronchomotor tone, cardiac rhythm, cough reflex pathways, and neuroimmune inflammatory responses. During lung cancer surgery, particularly during mediastinal lymphadenectomy, cardiopulmonary vagal branches may be exposed to traction, thermal injury, or …

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Primary Hyperparathyroidism Reveals Limited Adipose Remodeling in Human

A Palermo, Fabio Zaccaria, Andrea Ninni, Anda Mihaela Naciu et autres

ABSTRACT Background Preclinical models implicate the parathyroid hormone/parathyroid-hormone-related protein (PTH/PTHrP)-PTH1 receptor (PTH1R) axis in adipocyte lipolysis, adipose browning, and energy wasting. Whether this catabolic program is reproduced in vivo in humans remains unresolved. Primary hyperparathyroidism (PHPT), a condition of chronic endogenous PTH …

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Germline testing in lung cancer: evidence of enrichment without a standardized selection strategy – a systematic review

Fabrizio Citarella, Roberto Ferrara, Massimo Di Maio, Pierfilippo Crucitti et autres

BACKGROUND: Germline testing (GT) is increasingly integrated into oncology practice, yet its role in lung cancer (LC) remains undefined. While germline predisposition has clinical implications in several malignancies, LC is primarily driven by environmental factors and characterized by a relatively low prevalence …

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[18F]FDG PET/CT Radiomics for Predicting Pathological Risk Subtypes of Thymic Epithelial Tumors: A Bicentric Study

Antonio Sarubbi, Luca Frasca, Fatih Aksu, G Meduri et autres

Background: Thymic epithelial tumors (TETs) are rare mediastinal malignancies whose prognosis is largely determined by histology. Current predictive models rely on clinical variables and subjective imaging interpretation, with unsatisfied performance. Non-invasive pre-treatment risk stratification could guide surgical planning and perioperative management in …

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Evaluation of diagnostic accuracy and molecular adequacy between conventional endobronchial ultrasound, contrast-enhanced endobronchial ultrasound and elastography for hilar and mediastinal lymphadenopathies: a retrospective observational study

Luca Frasca, Ilaria Suriano, Antonio Sarubbi, Filippo Longo et autres

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a cornerstone for mediastinal staging in lung cancer; however, sampling of bulky or necrotic lymph nodes remains challenging, often leading to inadequate tissue for molecular analysis. This study aimed to compare the diagnostic accuracy …

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520P Enriching for pathogenic germline variants (PGVs) in lung cancer (LC): A systematic review of patient selection strategies

Fabrizio Citarella, R. Ferrara, M. Di Maio, Fiorella Gurrieri et autres

PGVs and likely pathogenic germline variants (LPGVs) involving DNA damage repair and cancer predisposition genes have been increasingly reported in patients with LC, particularly in non-small cell lung cancer (NSCLC). Current guidelines do not recommend routine germline testing (GT), and the optimal …

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369P Family history of cancer (FHC) in non-small cell lung cancer (NSCLC): A cross-sectional-prospective study to guide germline referral

Fabrizio Citarella, F.M. Venanzi, K. Takada, Pierfilippo Crucitti et autres

Conclusions: High CT usage shows geographic/smoking-linked variation but no link to early-stage lung cancer detection or resections.Rising scans parallel early detections without causation, questioning opportunistic screening efficacy outside targeted programs.

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Family history enrichment in Non-Small cell Lung Cancer: A cross-sectional − prospective study to inform referral for germline testing

Fabrizio Citarella, F.M. Venanzi, Giulia Di Giovanni, Kazuki Takada et autres

BACKGROUND: Family history of cancer (FHC) is a recognized proxy of inherited cancer susceptibility. In NSCLC, however, the clinical relevance of FHC remains poorly defined, and standardized approaches to identify patients enriched for pathogenic germline variants (PGVs) are lacking. METHODS: FAHIC-Lung (NCT06196424) …

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Inflammatory Indices Related to the Postoperative Prognosis of Thymic Epithelial Neoplasms: A Propensity Score Matching Evaluation

Federica Carlea, Alexandro Patirelis, Emanuele Voulaz, Veronica Maria Giudici et autres

BACKGROUND: Thymic epithelial tumors presented a variable 5-year survival rate, histological subtype dependent. Efforts have been made to identify new prognostic markers. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and Systemic Inflammatory Index (SII) proved effective in predicting survival in other solid tumors. …

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Molecular Landscape of Resected Thymomas: Insights from Mutational Profiling

Luca Frasca, Antonio Sarubbi, Lorenzo Nibid, Ilaria Suriano et autres

Background/Objectives: Thymomas are the most common tumors of the anterior mediastinum. While early-stage disease often has a favorable prognosis, therapeutic options in advanced stages remain limited. Moreover, the molecular profile of thymomas is still poorly characterized. In the present study, we explored …

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