Katharina Eisenächer

Interferon-induced activation of dendritic cells and monocytes by yellow fever vaccination correlates with early antibody responses

Elena Winheim, Antonio Santos‐Peral, Tamara Ehm, Linus Rinke et autres

Yellow fever vaccination provides long-lasting protection and is a unique model for studying the immune response to an acute RNA virus infection in humans. To elucidate the early innate immune events preceding the rapid generation of protective immunity, we performed transcriptome analysis …

hr, de, us, vn, fr (code pays fourni par la source)

Interferon-induced activation state of circulating dendritic cells and monocytes triggered by yellow fever vaccination correlates with early protective antibody responses

Elena Winheim, Antonio Santos‐Peral, Tamara Ehm, Linus Rinke et autres

Abstract Yellow fever vaccination provides long-lasting protection and is a unique model for studying the immune response to an acute RNA virus infection in humans. To elucidate the early innate immune events preceding the rapid generation of protective immunity, we performed transcriptome …

de, hr, fr (code pays fourni par la source)

Distinct and dynamic activation profiles of circulating dendritic cells and monocytes in mild COVID‐19 and after yellow fever vaccination

Elena Winheim, Tabea M. Eser, Flora Deák, Mohamed I. M. Ahmed et autres

Dysregulation of the myeloid cell compartment is a feature of severe disease in hospitalized COVID-19 patients. Here, we investigated the response of circulating dendritic cell (DC) and monocyte subpopulations in SARS-CoV-2 infected outpatients with mild disease and compared it to the response …

de (code pays fourni par la source)

Author response for "Distinct and dynamic activation profiles of circulating dendritic cells and monocytes in mild COVID‐19 and after yellow fever vaccination"

Elena Winheim, Tabea M. Eser, Flora Deák, Mohamed I. M. Ahmed et autres

Comparison of iron-reduced and iron-supplemented semisynthetic diets in T cell transfer colitis

Anamarija Markota, Rebecca Metzger, Alexander F. Heiseke, Lisa Jandl et autres

Clinical observations in inflammatory bowel disease patients and experimental studies in rodents suggest that iron in the intestinal lumen derived from iron-rich food or oral iron supplementation could exacerbate inflammation and that iron depletion from the diet could be protective. To test …

de (code pays fourni par la source)

Enteric Virome Sensing—Its Role in Intestinal Homeostasis and Immunity

Rebecca Metzger, Anne Krug, Katharina Eisenächer

Pattern recognition receptors (PRRs) sensing commensal microorganisms in the intestine induce tightly controlled tonic signaling in the intestinal mucosa, which is required to maintain intestinal barrier integrity and immune homeostasis. At the same time, PRR signaling pathways rapidly trigger the innate immune …

de (code pays fourni par la source)

Nucleic Acid Recognition in Dendritic Cells

Alexander F. Heiseke, Katharina Eisenächer, Anne Krug

de (code pays fourni par la source)

Virus-associated activation of innate immunity induces rapid disruption of Peyer’s patches in mice

Simon M Heidegger, David Anz, Nicolas Stephan, Bernadette Bohn et autres

Early in the course of infection, detection of pathogen-associated molecular patterns by innate immune receptors can shape the subsequent adaptive immune response. Here we investigate the influence of virus-associated innate immune activation on lymphocyte distribution in secondary lymphoid organs. We show for …

de, ch (code pays fourni par la source)

Regulation of RLR-mediated innate immune signaling – It is all about keeping the balance

Katharina Eisenächer, Anne Krug

de (code pays fourni par la source)

Functional analysis of cytosolic sensors of viral nucleic acids and their role for innate antiviral immune defense

Katharina Eisenächer

The cytoplasmic RNA helicases RIG-I, MDA5 and LGP2 sense viral RNA, leading to the induction of innate antiviral immunity. RIG-I is specifically activated by 5´-triphosphate RNA. Structural analyses revealed the presence of the regulatory domain (RD) at the C-terminus of RIG-I. The …

The IFN regulatory factor 7‐dependent type I IFN response is not essential for early resistance against murine cytomegalovirus infection

Christian Steinberg, Katharina Eisenächer, Olaf Groß, Wolfgang Reindl et autres

IFN regulatory factor 7 (IRF7) has been described as the master regulator of type I IFN responses and has been shown to be critical for innate antiviral immunity in vivo. In addition to type I IFN, NK cell responses are involved in …

de (code pays fourni par la source)

Extracellular and Intracellular Pattern Recognition Receptors Cooperate in the Recognition of Helicobacter pylori

Roland Rad, Wibke Ballhorn, Petra Voland, Katharina Eisenächer et autres

gb, de (code pays fourni par la source)