Rebecca Metzger

CCL17 Promotes Colitis-Associated Tumorigenesis Dependent on the Microbiota

Rebecca Metzger, Lis Winter, Nassim Bouznad, Debora Garzetti et autres

Colorectal cancer is one of the most common cancers and a major cause of mortality. Proinflammatory and antitumor immune responses play critical roles in colitis-associated colon cancer. CCL17, a chemokine of the C-C family and ligand for CCR4, is expressed by intestinal …

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Chemokine receptor 8 expression may be linked to disease severity and elevated interleukin 6 secretion in acute pancreatitis

Mwangala Nalisa, Ekene Emmanuel Nweke, Martin D. Payne Smith, J. Omoshoro–Jones et autres

BACKGROUND: Acute pancreatitis (AP) is an inflammatory disease, which presents with epigastric pain and is clinically diagnosed by amylase and lipase three times the upper limit of normal. The 2012 Atlanta classification stratifies the severity of AP as one of three risk …

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Increased Incidence of Colon Tumors in AOM-Treated Apc1638N/+ Mice Reveals Higher Frequency of Tumor Associated Neutrophils in Colon Than Small Intestine

Rebecca Metzger, Mahulena Marušková, Sabrina Krebs, Klaus‐Peter Janssen et autres

Colorectal cancer (CRC) is one of the most common cancers and a major cause of mortality. Mice with truncating Apc germline mutations have been used as a standard model of CRC, but most of the Apc-mutated lines develop multiple tumors in the …

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Comparison of iron-reduced and iron-supplemented semisynthetic diets in T cell transfer colitis

Anamarija Markota, Rebecca Metzger, Alexander F. Heiseke, Lisa Jandl et autres

Clinical observations in inflammatory bowel disease patients and experimental studies in rodents suggest that iron in the intestinal lumen derived from iron-rich food or oral iron supplementation could exacerbate inflammation and that iron depletion from the diet could be protective. To test …

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Digitale Patientenakten: Potential ausgeschöpft?

A. Parasta, Rebecca Metzger, H. Till, P. Kampmann et autres

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