Marco Terenzio

MYC-driven gliosis impairs neuron-glia communication in amyotrophic lateral sclerosis

Paolo Vincenzo Fioretti, Anna Barbieri, Alice Migazzi, Davide Bressan et autres

Chronic activation of glial cells leads to the dysfunction and degeneration of motor and cortical neurons in amyotrophic lateral sclerosis and frontotemporal dementia with an unknown mechanism. To shed light on the molecular pathogenetic processes underlying the exordium and contribution of gliosis …

it, us, gb, lb, es, bg, jp (code pays fourni par la source)

Impairment in axonal translation and cytoplasmic viscosity during aging in sensory neurons

Maria Fransiska Emily, Laurent Guillaud, Salvador Ruíz-Correa, Riya Agrawal et autres

Abstract Mitochondria are trafficked along axons and provide the energy required for several intracellular mechanisms including molecular transport and local translation, which is believed to contribute to the homeostasis of the axonal compartment. Decline in mitochondria activity is one of the hallmarks …

jp (code pays fourni par la source)

Loss of intracellular ATP affects axoplasmic viscosity and pathological protein aggregation in mammalian neurons

Laurent Guillaud, Anna Garanzini, Sarah Zakhia, Sandra de la Fuente et autres

Neurodegenerative diseases display synaptic deficits, mitochondrial defects, and protein aggregation. We show that intracellular adenosine triphosphate (ATP) regulates axoplasmic viscosity and protein aggregation in mammalian neurons. Decreased intracellular ATP upon mitochondrial inhibition leads to axoterminal cytosol, synaptic vesicles, and active zone component …

jp (code pays fourni par la source)

BPS2025 - SUPREM: An engineered non-site-specific m6A RNA methyltransferase with highly improved efficiency

Yoshiki Ochiai, Ben E. Clifton, Madeleine Le Coz, Marco Terenzio et autres

jp (code pays fourni par la source)

Nanographene-Based Polymeric Nanoparticles as Near-Infrared Emissive Neuronal Tracers

Hao Zhao, Laurent Guillaud, Maria Fransiska Emily, Xiushang Xu et autres

High Resolution Image Download MS PowerPoint Slide Precise tracking of axonal transport is key to deciphering neuronal functions. To achieve long-term imaging at both ultrastructural and macroscopic resolutions, it is critical to develop fluorescent transport tracers with high photostability and biocompatibility. Herein, …

jp, de (code pays fourni par la source)

Local translatome sustains synaptic function in impaired Wallerian degeneration

Maria Paglione, Leonardo Restivo, Sarah Zakhia, Arnau Llobet Rosell et autres

Abstract After injury, severed axons separated from their somas activate programmed axon degeneration, a conserved pathway to initiate their degeneration within a day. Conversely, severed projections deficient in programmed axon degeneration remain morphologically preserved with functional synapses for weeks to months after …

ch, jp (code pays fourni par la source)

SUPREM: an engineered non-site-specific m6A RNA methyltransferase with highly improved efficiency

Yoshiki Ochiai, Ben E. Clifton, Madeleine Le Coz, Marco Terenzio et autres

N 6-Methyladenine (m6A) RNA methylation plays a key role in RNA processing and translational regulation, influencing both normal physiological and pathological processes. Yet, current techniques for studying RNA methylation struggle to isolate the effects of individual m6A modifications. Engineering of RNA methyltransferases …

jp (code pays fourni par la source)

Intrinsic Burst-Blinking Nanographenes for Super-Resolution Bioimaging

Xingfu Zhu, Qiang Chen, Hao Zhao, Qiqi Yang et autres

Single-molecule localization microscopy (SMLM) is a powerful technique to achieve super-resolution imaging beyond the diffraction limit. Although various types of blinking fluorophores are currently considered for SMLM, intrinsic blinking fluorophores remain rare at the single-molecule level. Here, we report the synthesis of …

de, jp (code pays fourni par la source)

Roles of mRNA Axonal Localization and Translation in Neurodegenerative Diseases

Madeleine Le Coz, Sarah Zakhia, Marco Terenzio

Neurons are highly polarized cells with processes that extend over a meter in humans, thus requiring careful management of the structural and metabolic needs of their network. Indeed, neurons need to tightly regulate the flux of information from the periphery to the …

jp (code pays fourni par la source)

Mechanisms of axonal degeneration and regeneration of the nervous system

Miki Otsuki, Marco Terenzio

jp (code pays fourni par la source)

FMRP Long-Range Transport and Degradation Are Mediated by Dynlrb1 in Sensory Neurons

Sara Emad El-Agamy, Laurent Guillaud, Keiko Kono, Yibo Wu et autres

The fragile X messenger ribonucleoprotein 1 (FMRP) is a multifunctional RNA-binding protein implicated in human neurodevelopmental and neurodegenerative disorders. FMRP mediates the localization and activity-dependent translation of its associated mRNAs through the formation of phase-separated condensates that are trafficked by microtubule-based motors …

jp, ch (code pays fourni par la source)

SUPREM: an engineered non-site-specific m 6 A RNA methyltransferase with highly improved efficiency

Yoshiki Ochiai, Ben E. Clifton, Madeleine Le Coz, Marco Terenzio et autres

Abstract m 6 A RNA methylation plays a key role in RNA processing and translational regulation, influencing both normal physiological and pathological processes. Yet, current techniques for studying RNA methylation struggle to isolate the effects of individual m 6 A modifications. Engineering …

jp (code pays fourni par la source)