Santosh Kumar Yadav

Prevalence of Hemoglobinopathies in Different Age Groups- A One Year Study in Tertiary Care Centre

Sonia Chhabra, Santosh Kumar Yadav, Vaishali, Monika Gupta et autres

Aim and background Hemoglobinopathies such as thalassemia and sickle cell disease are among the most common genetic disorders in India, with carrier rates ranging from 3% to 17%. Each year, 9,000–10,000 new β-thalassemia cases are added, and prevalence is particularly high among …

in (code pays fourni par la source)

A Mathematical Modelling for Non- Newtonian Blood Flow through Stenotic Artery using Forward Time Central Space Scheme

Mahesh Chandra, Santosh Kumar Yadav

Arterial elasticity is a vital factor in regulating blood flow dynamics. Despite its importance, many computational studies simplify this by assuming arteries are rigid, which can lead to errors when predicting wall shear stress and pressure. This research utilizes a two way …

Antiphospholipid syndrome (APS) is a platelet factor 4 (PF4)-centric immunothrombotic disorder

Conroy O. Field, Amrita Sarka, Khalil Bdeir, Hyun‐Jun Kim et autres

Abstract Antiphospholipid syndrome (APS) is an immunothrombotic disorder, frequently attributed to autoantibodies that bind β2-glycoprotein I (β2GPI). A study showed that the platelet-specific chemokine, platelet factor 4 (PF4), binds to β2GPI, enhancing recognition of β2GPI by APS antibodies. APS antibodies induce the …

us, fr, pl (code pays fourni par la source)

Antiphospholipid syndrome (APS) is the newest member of the PF4 immunothrombotic family: Mechanistic and therapeutic insights

Conroy O. Field, Khalil Bdeir, Santosh Kumar Yadav, Kandace L. Gollomp et autres

Abstract Background: APS is an autoimmune thromboinflammatory disorder characterized by venous, arterial, and microvascular thrombosis, adverse pregnancy outcomes and thrombocytopenia. A major antigenic target is b2-glycoprotein I (b2GPI). Prior observations showed: i. b2GPI can bind the platelet chemokine, platelet factor 4 (PF4), …

us, fr (code pays fourni par la source)

Imaging tumor and ascites-associated macrophages in a mouse model of metastatic ovarian cancer

Catherine A. Foss, Flonné B. Wildes, Delia Mezzanzanica, Franca Podo et autres

Abstract Background Tumor-Associated Macrophages (TAMs) play a critical role in the pathogenesis and progression of ovarian cancer, a lethal gynecologic malignancy. [124I]iodo-DPA-713 is a PET radiotracer that is selectively trapped within reactive macrophages. We have employed this radioligand here as well as …

us, it (code pays fourni par la source)

517 Multiomics Atlas of oral and skin tissues reveals fibroblast heterogeneity

D.G. Pereira, Karl Annusver, Thomas B. W. Kirk, Santosh Kumar Yadav et autres

gb, se (code pays fourni par la source)

Why Do Peptidyl Arginine Deiminase (PAD) 4-Deficient Mice Have Improved Survival Following Cecal Ligation and Puncture (CLP) Sepsis? Implications for the Role Neutrophil Extracellular Trap (NETs) in Immune Homeostasis

Veronica Bochenek, Abigail E Skidmore, Anh T. P. Ngo, Samir Maarouf et autres

Background: NETs are webs of decondensed chromatin that capture and kill bacteria. However, when released in a dysregulated manner, NETs can cause collateral tissue injury to the host. In prior studies designed to understand the role of NETs in sepsis, mice deficient …

us (code pays fourni par la source)

Anti-Phospholipid Syndrome (APS) Antibody (Ab)-Induced Thrombosis Can be Blocked By Platelet Factor 4 (PF4)-Directed Abs: A Novel Therapeutic Approach for APS?

Amrita Sarkar, Santosh Kumar Yadav, Conroy O. Field, Kandace L. Gollomp et autres

Background: APS is an autoimmune thromboinflammatory disease characterized by thrombocytopenia, thrombosis, and/or complications in pregnancy. APS occurs in association with one or more antiphospholipid (aPL) Abs/IgGs whose major target is b2-glycoprotein I (b2GPI), a protein previously shown to bind to human (h) …

us, fr (code pays fourni par la source)

Association of neuroanatomical changes with neuropsychological changes in Treated Adult HIV-Positive Patients

Ajin Joy, Rajakumar Nagarajan, Eric S. Daar, Jhelum Paul et autres

This study was designed to use the structural MRI data to characterize volumetric changes in gray matter and white matter, and to determine variations in cortical thickness, in a group of HIV-infected individuals to understand how their brain structural changes are associated …

POS1363 MRI HAND FINDINGS IN PATIENTS WITH EARLY INFLAMMATORY ARTHRITIS: A CROSS-SECTIONAL STUDY

Amey P. Patankar, Santosh Kumar Yadav, Navya Thirumaleshwar Hegde, G K Sachdev et autres

Background: MRI is useful in assessing inflammatory soft tissue and bone involvement, including synovitis, tenosynovitis, osteitis, and erosions, in patients with early inflammatory arthritis (EIA). Over 90% of patients with EIA show MRI evidence of synovitis, and 70-80% have tenosynovitis [1]. It …

in (code pays fourni par la source)

Clinical Outcome of Open Reduction and Internal Fixation of Mandibular Condyle Fracture: A Prospective Observational Study

Arun Kumar Shah, Shailesh Gautam, Nitesh Chaurasia, Santosh Kumar Yadav

Introduction: Condyle of mandible plays crucial role in functioning of jaw. Untimely and inadequate treatment leads to deformity of face along with range of complications. The purpose of this study was to assess outcomes of open reduction and internal fixation of mandibular …

np (code pays fourni par la source)

Role of miRNAs in T‐cell activation and Th17/Treg‐cell imbalance in acquired aplastic anemia

Ghaeeb Sabreen, Khaliqur Rahman, Ruchi Gupta, Chandra Prakash Chaturvedi et autres

Abstract Background Altered T‐cell repertoire with an aberrant T‐cell activation and imbalance of the Th17/Treg cells has been reported in acquired aplastic anemia (aAA). miRNAs are well known to orchestrate T‐cell activation and differentiation, however, their role in aAA is poorly characterized. …

in (code pays fourni par la source)