Elvis Alvarez Carnero

Mapping Sedentary Human Fitness And Clinical Features: Multi-omic Baseline Architecture And Acute Exercise Dynamics In The Molecular Transducers Of Physical Activity Consortium (MoTrPAC) Project

Samuel Montalvo, Prashant Rao, Nikolai G. Vetr, Kristen J. Sutton et autres

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Changes in Walking Energy Expenditure and Substrate Oxidation during Pregnancy

Ana Martinez Cagiao, Juan Fariñas, Jéssica Rial-Vázquez, María Rúa-Alonso et autres

Abstract Introduction obesity and unhealthy weight gain during pregnancy are associated with risk of pregnancy complications. Management of energy balance during pregnancy needs an accurate assessment of intake and energy expenditure. As pregnancy promotes specific physiological changes, energy expenditure during rest and …

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1211-OR: ADA Presidents' Select Abstract: Impaired Metabolic Flexibility in Type 1 Diabetes May Be Offset by Greater Physical Activity

Daria Igudesman, Audrey Collins, Dessi Zaharieva, Meryem Talbo et autres

Introduction and Objective: Metabolic inflexibility, or an inability to switch between fat and carbohydrate oxidation, has not been thoroughly investigated in T1D despite its close link with skeletal muscle insulin resistance—an established feature of T1D. We investigated whether T1D is characterized by …

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Modeling the microbial contribution to human energy balance using the Digestion, Absorption, and Microbial Metabolism (DAMM) model

Taylor L. Davis, Blake Dirks, Elvis Alvarez Carnero, Karen D. Corbin et autres

Colonic microorganisms have been linked to human health and disease, specifically metabolic disease states such as obesity, but causal relationships remain to be established. Previous work demonstrated that interactions between the host's diet and intestinal microbiome were associated with human energy balance …

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Microbial Feast or Famine: dietary carbohydrate composition and gut microbiota metabolic function

Blake Dirks, Alex E. Mohr, Karen D. Corbin, Elvis Alvarez Carnero et autres

systems, animal models, and human participants, most of these studies focused primarily on microbial-community composition and lacked the functional information that can be gained from transcript-level analyses. In this exploratory analysis, we use metatranscriptomic data to gain a functional perspective on how …

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MoTrPAC Cpet Core Lab - Quality Control And Threshold Determinations

Elvis Alvarez Carnero, Brian J. Coyne, Jeffrey Wilcox Christle, Peter Brubaker et autres

The Molecular Transducers of Physical Activity Consortium (MoTrPAC) protocol includes collection of cardiopulmonary exercise testing (CPET) data as a key clinical outcome. PURPOSE: Due to the large volume of data and institutions involved in MoTrPAC, a CPET Core Lab was created to …

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Global Metabolite Profiling in Feces, Serum, and Urine Yields Insights into Energy Balance Phenotypes Induced by Diet-Driven Microbiome Remodeling

Daria Igudesman, Gongxin Yu, Tumpa Dutta, Elvis Alvarez Carnero et autres

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Physical activity pattern and Pre-eclampsia risk biomarkers: an observational study

Ana Martinez Cagiao, Pablo Aleixandre Diaz Brage, Manuel-Avelino Giráldez, Marta Torres-Tarrío et autres

Screening tests for preterm pre-eclampsia (PE) include maternal risk factors, mean arterial blood pressure (MAP), uterine artery pulsatility index (UtA-PI) and serum placental growth factor (PlGF). Exercise interventions have been shown to improve vascular function in pregnant women, which could mediate improvements …

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Validation of Accelerometry Cut-off Points to Categorize Physical Activity Intensity Along the Pregnancy

Ana Martinez Cagiao, Juan Fariñas, Jéssica Rial-Vázquez, María Rúa-Alonso et autres

Abstract Background Several studies have created and validated accelerometry cut-off points to categorize intensities of physical activity (PA); however, there is not specific cut-off points in pregnant women. Pregnancy promotes specific physiological and biomechanical changes that can modify quantitively the relationship between …

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Exercise alters molecular profiles of inflammation and substrate metabolism in human white adipose tissue

Maria F. Pino, Pieter Ubele Dijkstra, Katie L. Whytock, Cheehoon Ahn et autres

This is the first study to utilize a multiomic (RNAseq, proteomics, and phosphoproteomics) approach to investigate molecular adaptations in WAT after a short-term intervention in sedentary overweight women. We show that supervised aerobic training reduces molecular markers of inflammation and proteins regulating …

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Global metabolite profiling in feces, serum, and urine yields insights into energy balance phenotypes induced by diet-driven microbiome remodeling

Daria Igudesman, Gongxin Yu, Tumpa Dutta, Elvis Alvarez Carnero et autres

Background: Preclinical literature and behavioral human data suggest that diet profoundly impacts the human gut microbiome and energy absorption-a key determinant of energy balance. To determine whether these associations are causal, domiciled controlled feeding studies with precise measurements of dietary intake and …

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MOTRPAC CPET CORE LAB - QUALITY CONTROL AND THRESHOLD DETERMINATIONS

Brian J. Coyne, Elvis Alvarez Carnero, Jeffrey Wilcox Christle, Peter Brubaker et autres

https://youtu.be/KAfCLUuf1XY INTRODUCTION The Molecular Transducers of Physical Activity Consortium (MoTrPAC) protocol includes collection of cardiopulmonary exercise testing (CPET) data as a key clinical outcome. Due to the large volume of data and institutions involved in MoTrPAC, a CPET Core Lab was created …

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