Cheehoon Ahn

Adiposity and Cognitive Performance in Older Men and Women from the Study of Muscle, Mobility and Aging (SOMMA)

John J. Dubé, Haley N. Barnes, Zofia Ross, Neharika Murthy et autres

BACKGROUND: Aging is accompanied by changes in body composition and cognition. Although adiposity has been linked to metabolic dysfunction and dementia risk, associations with specific cognitive domains in later life remain unclear. METHODS: This cross-sectional study examined associations between adiposity and cognitive …

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Mapping Sedentary Human Fitness And Clinical Features: Multi-omic Baseline Architecture And Acute Exercise Dynamics In The Molecular Transducers Of Physical Activity Consortium (MoTrPAC) Project

Samuel Montalvo, Prashant Rao, Nikolai G. Vetr, Kristen J. Sutton et autres

us, il (code pays fourni par la source)

Exercise Training Remodels The Composition Of Skeletal Muscle Extracellular Matrix And Key Regulators In Adults With Obesity

Tao Zhang, Cheehoon Ahn, Rebecca Tuska, Xinyi Kong et autres

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Multi-omic responses to acute exercise in abdominal subcutaneous adipose tissue of sedentary adults: findings from MoTrPAC

Cheehoon Ahn, Christopher A. Jin, Katie L. Whytock, Gina M. Many et autres

Exercise induces widespread health benefits across multiple tissues, yet the acute molecular responses in human adipose tissue remain poorly defined. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) profiled temporal molecular changes in abdominal subcutaneous adipose tissue (ASAT) following a single bout …

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Multi-Omic, Multi-Tissue Responses to Acute Exercise in Sedentary Adults: Findings from the Molecular Transducers of Physical Activity Consortium

MoTrPAC Study Group, Daniel H. Katz, Christopher A. Jin, Gina M. Many et autres

Regular physical activity represents one of the greatest mechanisms for maintaining human health, yet the underlying molecular transducers of these benefits remain incompletely understood. Multi-omic assays now provide new opportunities to study the coordinated molecular responses of body tissues to different exercise …

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Single‐Nuclei Resolution of Intermuscular Adipose Tissue Indicates an Inflammation‐Associated Cellular Profile in Individuals With Knee Osteoarthritis: Findings From the SOMMA KOA Ancillary Study

Line O. Elingaard‐Larsen, Katie L. Whytock, Adeline Divoux, Cheehoon Ahn et autres

Individuals with knee osteoarthritis (KOA) have skeletal muscle changes around the knee joint including reduced quadricep muscle mass and increased intermuscular adipose tissue (IMAT). We examined the cellular composition and transcriptional profiles using single-nuclei RNA sequencing in IMAT from 6 older women …

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Molecular responses in abdominal subcutaneous adipose tissue after a session of endurance exercise: effects of exercise intensity

Cheehoon Ahn, Tao Zhang, Thomas Rode, Gayoung Yang et autres

Abstract The primary aim of this study was to compare the acute effects of three exercise intensities on abdominal subcutaneous adipose tissue (aSAT) transcriptome in regular exercisers. A total of 45 adults who exercise regularly were assigned to perform a single session …

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Exercise training remodels inter-organ endocrine networks

Cheehoon Ahn, Andrea L. Hevener, Laurie J. Goodyear, Sue C. Bodine et autres

BACKGROUND: Exercise induces organism-wide molecular adaptations, partly mediated by humoral factors released in response to acute and chronic physical activity. However, the extent and specificity of endocrine effects from training-induced secreted factors remain unclear. METHODS: Here, we applied systems genetics approaches to …

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Subcutaneous adipose tissue-secreted proteins as endocrine regulators of physical and cognitive function in older adults

Cheehoon Ahn, Ian Tamburini, James Sanford, Mingqi Zhou et autres

Declines in skeletal muscle and cognitive function in older adults have been linked to abnormalities in abdominal subcutaneous adipose tissue (ASAT), yet the underlying molecular mediators remain poorly understood. Here, leveraging ASAT transcriptomics and explant-conditioned media proteomics from participants in the Study …

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Subcutaneous Adipose Tissue-Secreted Proteins as Endocrine Regulators of Physical and Cognitive Function in Older Adults

Lauren M. Sparks, Cheehoon Ahn, Ian Tamburini, James Sanford et autres

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Acute session of three endurance exercise intensities alters subcutaneous adipose tissue transcriptome in regular exercisers

Cheehoon Ahn, Tao Zhang, Thomas Rode, Gayoung Yang et autres

ABSTRACT The primary aim of this study was to compare the acute effects of three exercise intensities on abdominal subcutaneous adipose tissue (aSAT) transcriptome in regular exercisers. A total of 45 adults who exercise regularly were assigned to perform a single session …

us (code pays fourni par la source)

Exercise training remodels inter-organ endocrine networks

Cheehoon Ahn, Andrea L. Hevener, Laurie J. Goodyear, Sue C. Bodine et autres

Exercise induces organism-wide molecular adaptations, partly mediated by humoral factors released in response to acute and chronic physical activity. However, the extent and specificity of endocrine effects from training-induced secreted factors remain unclear. Here, we applied systems genetics approaches to quantify inter-organ …

us (code pays fourni par la source)