Scott Jennings

Myeloperoxidase gene knockout causes local inflammation and dysbiosis in the murine gut

Yawen Hu, Scott Jennings, Meng Luo, Christopher M. Taylor et autres

Myeloperoxidase (MPO), predominantly expressed in neutrophils, catalyzes the production of hypochlorous acid (HOCl) that plays an integral role in the host defense against invading pathogens. However, little is known about its role in maintaining normal gut microbiome and function. Here, we report …

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Normalization of Cystic Fibrosis Immune System Reverses Intestinal Neutrophilic Inflammation and Significantly Improves the Survival of Cystic Fibrosis Mice

Callie Scull, Yawen Hu, Scott Jennings, Guoshun Wang

BACKGROUND & AIMS: Cystic fibrosis (CF) is an autosomal recessive genetic disorder, affecting multiple organ systems. CF intestinal disease develops early, manifesting as intestinal bacterial overgrowth/dysbiosis, neutrophilic inflammation, and obstruction. As unresolvable infection and inflammation reflect host immune deficiency, we sought to …

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Loss of CFTR function in macrophages alters the cell transcriptional program and delays lung resolution of inflammation

Dianne Wellems, Yawen Hu, Scott Jennings, Guoshun Wang

Cystic fibrosis (CF) is an autosomal recessive genetic disorder caused by mutations in the CF Transmembrane-conductance Regulator (CFTR) gene. The most severe pathologies of CF occur in the lung, manifesting as chronic bacterial infection, persistent neutrophilic inflammation, and mucopurulent airway obstruction. Despite …

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Aberrant immune programming in neutrophils in cystic fibrosis

Yawen Hu, Christine M. Bojanowski, Clemente J. Britto, Dianne Wellems et autres

Cystic fibrosis is a life-shortening genetic disorder, caused by mutations in the gene that encodes cystic fibrosis transmembrane-conductance regulator, a cAMP-activated chloride and bicarbonate channel. Persistent neutrophilic inflammation is a major contributor to cystic fibrosis lung disease. However, how cystic fibrosis transmembrane-conductance …

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Data from TLE1 Is an Anoikis Regulator and Is Downregulated by Bit1 in Breast Cancer Cells

Chris Brunquell, Hector Biliran, Scott Jennings, Shubha Kale Ireland et autres

Abstract TLE1 is a Groucho-related transcriptional repressor protein that exerts survival and antiapoptotic function in several cellular systems and has been implicated in the pathogenesis of cancer. In the present study, we found that TLE1 is a regulator of anoikis in normal …

Neutrophil defect and lung pathogen selection in cystic fibrosis

Scott Jennings, Yawen Hu, Dianne Wellems, Meng Luo et autres

Cystic fibrosis is a life-threatening genetic disorder caused by mutations in the CFTR chloride channel. Clinically, over 90% of patients with cystic fibrosis succumb to pulmonary complications precipitated by chronic bacterial infections, predominantly by Pseudomonas aeruginosa and Staphylococcus aureus. Despite the well-characterized …

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ABERRANT IMMUNE PROGRAMMING IN NEUTROPHILS IN CYSTIC FIBROSIS

Yawen Hu, Christine M. Bojanowski, Clemente J. Britto, Dianne Wellems et autres

ABSTRACT Cystic fibrosis (CF) is a life-shortening genetic disorder, caused by mutations in the gene that encodes Cystic Fibrosis Transmembrane-conductance Regulator (CFTR), a cAMP-activated chloride and bicarbonate channel. Although multiple organ systems can be affected, CF lung disease claims the most morbidity …

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Cftr deletion in mouse epithelial and immune cells differentially influence the intestinal microbiota

Callie Scull, Meng Luo, Scott Jennings, Christopher M. Taylor et autres

Cystic fibrosis (CF) is a life-threatening genetic disorder, caused by mutations in the CF transmembrane-conductance regulator gene (cftr) that encodes CFTR, a cAMP-activated chloride and bicarbonate channel. Clinically, CF lung disease dominates the adult patient population. However, its gastrointestinal illness claims the …

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Comparison of Proportion of Elevated Carcinoembryonic Antigen Levels in Patients With Appendiceal and Colorectal Adenocarcinoma: A Systematic Review and Meta-analysis

Adam Cristaudo, Scott Jennings, David L. Morris

BACKGROUND/AIM: The proportion of patients with liver metastases in patients with appendiceal versus colorectal adenocarcinomas was 3.1 percent and 24 percent, respectively, in our peritonectomy centre. From our internal analyses, carcinoembryonic antigen (CEA) was potentially involved. A hypothesis was proposed regarding the …

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977TiP Role of microbiome as a biomarker in locoregionally-advanced oropharyngeal squamous cell carcinoma 2 (ROMA LA-OPSCC2)

Geoffrey Alan Watson, Marc Oliva, B. Chen, Anneli Eliason et autres

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Myeloid CFTR loss-of-function causes persistent neutrophilic inflammation in cystic fibrosis

Hang Pong Ng, Scott Jennings, Dianne Wellems, Fei Sun et autres

Persistent neutrophilic inflammation is a hallmark of cystic fibrosis (CF). However, the mechanisms underlying this outstanding pathology remain incompletely understood. Here, we report that CFTR in myeloid immune cells plays a pivotal role in control of neutrophilic inflammation. Myeloid CFTR-Knockout (Mye-Cftr-/-) mice …

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Operative Results of Mitral Valve Repair and Replacement in Chronic Ischaemic Mitral Valve Regurgitation

Damian Gimpel, Michael Cheung, Levi Bassin, Scott Jennings et autres

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