Adam Cristaudo

Prognostic value of carcinoembryonic antigen in colorectal adenocarcinoma: expanding hypotheses into clinical practice

Adam Cristaudo, David L. Morris

PURPOSE: This study seeks to resolve a fundamental question in oncology: Why do appendiceal and colorectal adenocarcinomas exhibit distinct liver metastasis rates? Building on our prior hypothesis published in the British Journal of Surgery, our institution has investigated potential DNA mutations within …

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Mutations of the CEACAM5 Gene PELPK Motif in Patients With Appendiceal or Colorectal Adenocarcinoma

Adam Cristaudo, Shoma Barat, Nima Ahmadi, David L. Morris

BACKGROUND/AIM: The study examines whether DNA level mutations in the carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) gene Pro-Glu-Leu-Pro-Lys (PELPK) motif differ between patients with appendiceal or colorectal adenocarcinoma. Significant differences between these two groups in correlation with development of metachronous liver …

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Comparison Of carcinoembryonic antigen levels between Portal and PERipheral blood in patients with appendiceal adenocarcinoma (COPPER) trial

Adam Cristaudo, David L. Morris, Mohammad Breakeit

In 1987, Tabuchi et al.1 conducted a study to investigate the drainage of carcinoembryonic antigen (CEA) in colorectal cancer, which suggested that CEA is released into the portal blood from primary colonic cancer lesions. Recently, the role of CEA in promoting liver …

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Re: Development and validation of a multivariable prediction model in open abdomen patients for entero‐atmospheric fistula

Adam Cristaudo, Kerry Hitos, Ronny Gunnarsson, Alan de Costa et autres

We would like to provide an update regarding a retrospective cohort study published in the ANZ Journal of Surgery in 2022 describing the development and validation of a multivariable prediction model for entero-atmospheric fistula in patients managed with an open abdomen (OA).1 …

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Increased Incidence of Liver Metastases in ColorectalVersusAppendiceal Adenocarcinoma Peritonectomy Patients Despite Equivocal Survival

Celine Garrett, Adam Cristaudo, Shoma Barat, David L. Morris

BACKGROUND/AIM: Colorectal adenocarcinoma (CRAdenoCa) and appendiceal adenocarcinoma (AAdenoCa) are diseases of the same histopathological type that metastasise to the liver and peritoneum. In selected subgroups, peritonectomy and heated intraperitoneal chemotherapy (HIPEC) may be indicated as part of the multimodal treatment plan. However, …

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The ‘Starburst’ Sign: A Novel Description of PET Images in Carcinoma of Unknown Primary

Adam Cristaudo, David L. Morris, Shoma Barat

BACKGROUND/AIM: Carcinoma of unknown primary (CUP) poses a formidable diagnostic challenge, characterised by high mortality rates and an elusive primary tumour site. While Positron emission tomography (PET) scans are routinely employed in the initial evaluation of CUP patients, identifying the primary tumour …

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Comparison of Proportion of Elevated Carcinoembryonic Antigen Levels in Patients With Appendiceal and Colorectal Adenocarcinoma: A Systematic Review and Meta-analysis

Adam Cristaudo, Scott Jennings, David L. Morris

BACKGROUND/AIM: The proportion of patients with liver metastases in patients with appendiceal versus colorectal adenocarcinomas was 3.1 percent and 24 percent, respectively, in our peritonectomy centre. From our internal analyses, carcinoembryonic antigen (CEA) was potentially involved. A hypothesis was proposed regarding the …

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Development and validation of a multivariable prediction model in open abdomen patients for entero‐atmospheric fistula

Adam Cristaudo, Kerry Hitos, Ronny Gunnarsson, Alan de Costa

BACKGROUND: Laparostomy or Open Abdomen (OA) has matured into an effective strategy in the management of abdominal catastrophe. Single prognostic factors have been identified in a previous systematic review regarding entero-atmospheric fistula (EAF). Unfortunately, no prognostic multivariable model for EAF exist. The …

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Hypothesis to explain the disparity in the proportion of liver metastases between appendiceal and colorectal cancer

Adam Cristaudo, David L. Morris

Dear Editor Within our institution, the authors recently noted a significant disparity in the proportion of liver metastases between appendiceal and colorectal adenocarcinomas (3.1 and 24 per cent respectively). This is consistent with current literature, which describes 2–5 per cent of patients …

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Prognostic factors in the management of the open abdomen

Adam Cristaudo

In the management of critically ill surgical patients with an open abdomen, predicting their probability of developing a certain complication or outcome might aid in their safe management until definitive fascial closure can be achieved. The objectives of this research were to …

EP-1568 Long-term results of [18F] Fluorocholine PET/CT guided SBRT in patients with prostate cancer

Francesco Pasqualetti, M. Panichi, Paola Cocuzza, Alessandra Gonnelli et autres

Purpose or Objective Aim: In the last years, functional imaging has given a significant contribution to the clinical decision making of biochemical relapsed prostate cancer (PCa), allowing early diagnosis of metastatic disease with a limited tumor burden, the so-called oligometastatic patients, and …

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EP-1496: The natural history of pulmonary micronodules evidenced at initial CT scan in pts affected by LARC

S. Montrone, Francesco Pasqualetti, Riccardo Morganti, B. Manfredi et autres