2026
article
OpenAlex
Asmaa Yousif, Amir Yousif, Ava Lowin, Abbey Saadey et autres
Abstract Introduction Exhaustion of CD8 T cells during cancer or chronic infections remains a significant barrier to T cell immunotherapies. Recent studies showed that distinct epigenetic changes drive exhaustion by silencing effector and memory-related genes, thereby establishing the dysfunctional state of exhausted …
us
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2026
article
OpenAlex
Abbey Saadey, Amir Yousif, Ava Lowin, Kelley Ptak et autres
Abstract Introduction Cytotoxic CD8+ T cells progressively lose function and become terminally exhausted during chronic infections and cancer. We previously showed that chronic antigen exposure plus TGFβ1 signals drive epigenetically imprinted terminal exhaustion programs in CD8 T cells. In contrast, activating bone …
us
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2026
conference-abstract
OpenAlex
Achintya Perumal, Grant Brennan, Jiayao Ye, Hu Chen et autres
Abstract For tumor immunotherapy to succeed, CD8+ T cells must efficiently migrate into tumor sites, yet the molecular pathways controlling this critical step of T-cell trafficking remain only partially understood. Using a novel reverse-engineered strategy—starting from antigen-experienced CD8+ T cells that either …
us
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Accès ouvert
2025
article
OpenAlex
Abbey A. Saadey, Amir Yousif, Ava M. Lowin, Kelley Ptak et autres
Abstract Description T cell exhaustion is a major barrier to effective cytotoxic CD8+ T cell immune responses during chronic infections or cancer. Epigenetic silencing of key effector function and memory-related genes reinforces T cell exhaustion, limiting the capacity of CD8+ T cells …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Amir Yousif, Abbey A. Saadey, Ava M. Lowin, Ankita Saini et autres
Epigenetic scarring of terminally dysfunctional (TDysf) CD8+ T cells hinders long-term protection and response to immune checkpoint blockade during chronic infections and cancer. We developed a faithful in vitro model for CD8+ T cell terminal dysfunction as a platform to advance T …
ca, gb, us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Amir Yousif, Abbey A. Saadey, Ava M. Lowin, Ankita Saini et autres
Abstract Epigenetic scarring of terminally dysfunctional CD8 T cells hinders long-term protection and response to immune checkpoint blockade during chronic infections and cancer. We developed a faithful in vitro model for CD8 T cell terminal dysfunction as a platform to advance T …
us
(code pays fourni par la source)
1999
article
OpenAlex
Kelley Ptak, Ge´rard Hilaire
fr
(code pays fourni par la source)