Sayaka Takemoto‐Kimura

A hypofunctional PREX1 variant (p.Y191C) leads to neurodevelopmental abnormalities and epilepsy by attenuating RAC1 signaling

Masashi Nishikawa, Yuri Uchiyama, Kazuyuki Nakamura, Mitsuhiro Kato et autres

The RAC subfamily of Rho family small GTPases plays a crucial role in neurodevelopment by regulating cellular signaling pathways and the actin cytoskeleton. The activity of RAC is controlled by guanine nucleotide exchange factors (GEFs), which facilitate the transition from an inactive …

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A preoptic circuit triggers rewarming from torpor

Akinobu Ohba, Madoka Narushima, Chengru Shao, Chijung Hung et autres

Abstract Torpor is an adaptive hypometabolic state that enables homeotherm to survive periods of energetic challenge. This strategy ranges from short bouts of daily torpor to prolonged hibernation. During torpor, animals markedly suppress metabolic rate, body temperature, heart rate, and respiration, while …

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Neurotensin in the extended amygdala maintains wakefulness in novel environments

Chi Jung Hung, Shuhei Ueda, Sheikh Mizanur Rahaman, Mikiyasu Yamamoto et autres

Animals remain awake in unfamiliar environments to assess potential safety threats, a process involving changes in neuronal activity within sleep–wake regulatory brain regions. However, the specific circuits and neurotransmitters involved remain poorly understood. Here, we show that neurotensin (NTS) peptides in corticotropin-releasing …

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Cortical excitatory and inhibitory neuron deficits may underlie the cognitive and social impairments in a mouse model of schizophrenia with exonic Reln deletion

Kanako Kitagawa, Daisuke Mori, Tetsuo Matsuzaki, Taku Nagai et autres

Reelin is an essential extracellular matrix glycoprotein that regulates cortical layers formation and has been implicated in several neuropsychiatric conditions, including schizophrenia (SCZ). To explore its role in brain function and its potential involvement in SCZ, we developed a Reln heterozygous deletion …

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Divergent and subnucleus-specific gene expression responses to chronic stress hormone exposure in the amygdala

Shuhei Ueda, Manami Kakita, Masahito Hosokawa, Koji Arikawa et autres

Major depressive disorder (MDD) is one of the most prevalent mental disorders, posing a significant socioeconomic burden worldwide. Its development involves both genetic and environmental factors, among which chronic stress is considered a major contributor. The amygdala, a key brain region for …

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Cortical excitatory and inhibitory neuron deficits may underlie the cognitive and social impairments in a mouse model of schizophrenia with exonic Reln deletion

Kanako Kitagawa, Daisuke Mori, Tetsuo Matsuzaki, Taku Nagai et autres

Abstract Reelin is an essential extracellular matrix glycoprotein involved in the formation of cortical layers and has been associated with several neuropsychiatric conditions, such as schizophrenia (SCZ). To explore its role in brain function and its potential involvement in SCZ, we developed …

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A hyper-activatable CAMK2A variant associated with intellectual disability causes exaggerated long-term potentiation and learning impairments

Miao Pan, Pin-Wu Liu, Yukihiro Ozawa, Fumiko Arima‐Yoshida et autres

Intellectual disability (ID) is a neurodevelopmental disorder (NDD) characterized by impairments in intellectual and adaptive functioning, and is highly co-morbid with other NDDs. Recently, de novo missense variants in the gene, CAMK2A, which encodes calcium/calmodulin-dependent protein kinase IIα (CaMKIIα), an abundant neuronal …

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EXPLORING MOLECULAR CHANGES IN THE EXTENDED AMYGDALA INDUCED BY CHRONIC CORTICOSTERONE ADMINISTRATION

Shuhei Ueda, Masahito Hosokawa, Manami Kakita, Koji Arikawa et autres

Abstract Chronic stress is a significant risk factor for multiple psychiatric disorders, including depression. When exposed to social and/or environmental stressors, the hypothalamic-pituitary-adrenal (HPA) axis becomes activated, leading to the release of glucocorticoids (cortisol in humans, corticosterone in rodents) from the adrenal …

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Exploring the molecular and neuronal bases involved in central amygdala-dependent control of emotional behaviors

Shuhei Ueda, Sayaka Takemoto‐Kimura

The central extended amygdala, including the central nucleus of the amygdala (CeA) and the lateral division of the bed nucleus of the stria terminalis (BNSTL), is a pivotal brain region involved in the threat processing responsible for emotional states such as fear …

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Ca2+ Imaging in Immature Cortical Neurons

Shin‐ichiro Horigane, Sayaka Takemoto‐Kimura

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Lipidation states orchestrate CLICK-III/CaMKIγ's stepwise association with Golgi and rafts-enriched membranes and specify its functional coupling to STEF-Rac1-dependent neurite extension

Natsumi Ageta‐Ishihara, Sayaka Takemoto‐Kimura, Yayoi Kondo, Michiko Okamura et autres

CLICK-III/CaMKIγ is a lipid-anchored neuronal isoform of multifunctional Ca2+/calmodulin-dependent protein kinases, which mediates BDNF-dependent dendritogenesis in cultured cortical neurons. We found that two distinct lipidation states of CaMKIγ, namely, prenylation and palmitoylation, controlled its association with detergent-resistant microdomains in the dendrites and …

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Experience-dependent changes in affective valence of taste in male mice

Shun Hamada, Kaori Mikami, Shuhei Ueda, Masashi Nagase et autres

Taste plays an essential role in the evaluation of food quality by detecting potential harm and benefit in what animals are about to eat and drink. While the affective valence of taste signals is supposed to be innately determined, taste preference can …

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