Experience-dependent changes in affective valence of taste in male mice
Rattachement africain : jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Taste plays an essential role in the evaluation of food quality by detecting potential harm and benefit in what animals are about to eat and drink. While the affective valence of taste signals is supposed to be innately determined, taste preference can also be drastically modified by previous taste experiences of the animals. However, how the experience-dependent taste preference is developed and the neuronal mechanisms involved in this process are poorly understood. Here, we investigate the effects of prolonged exposure to umami and bitter tastants on taste preference using two-bottle tests in male mice. Prolonged umami exposure significantly enhanced umami preference with no changes in bitter preference, while prolonged bitter exposure significantly decreased bitter avoidance with no changes in umami preference. Because the central amygdala (CeA) is postulated as a critical node for the valence processing of sensory information including taste, we examined the responses of cells in the CeA to sweet, umami, and bitter tastants using in vivo calcium imaging. Interestingly, both protein kinase C delta (Prkcd)-positive and Somatostatin (Sst)-positive neurons in the CeA showed an umami response comparable to the bitter response, and no difference in cell type-specific activity patterns to different tastants was observed. Meanwhile, fluorescence in situ hybridization with c-Fos antisense probe revealed that a single umami experience significantly activates the CeA and several other gustatory-related nuclei, and especially CeA Sst-positive neurons were strongly activated. Intriguingly, after prolonged umami experience, umami tastant also significantly activates the CeA neurons, but the Prkcd-positive neurons instead of Sst-positive neurons were highly activated. These results suggest a relationship between amygdala activity and experience-dependent plasticity developed in taste preference and the involvement of the genetically defined neural populations in this process.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Experience-dependent changes in affective valence of taste in male mice
- Date Crossref
- 11/03/2023
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Yamanashi pays non établi dans la noticeUniversité ou école supérieure
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Jikei University School of Medicine Institute of Clinical Medicine and Research pays non établi dans la noticeUniversité ou école supérieure
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Nagoya University Department of Molecular/Cellular Neuroscience pays non établi dans la noticeUniversité ou école supérieure
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The University of Tokyo pays non établi dans la noticeUniversité ou école supérieure
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Jikei University Kashiwa hospital pays non établi dans la noticeÉtablissement de santé
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Faculty of Medicine Department of Biochemistry pays non établi dans la noticeUniversité ou école supérieure
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Graduate School of Medicine Department of Neurochemistry pays non établi dans la noticeUniversité ou école supérieure
University of Yamanashi, Institute of Clinical Medicine and Research — Jikei University School of Medicine et Department of Molecular/Cellular Neuroscience — Nagoya University, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.