Xiumiao He

Genetic and pathogenic characterization of a novel infectious bursal disease virus field strain with natural reassortant and recombinant features from southern China

Minhui Zhao, W L Zuo, Huang Zhiyong, Ruiyang Kong et autres

Infectious bursal disease (IBD), caused by infectious bursal disease virus (IBDV), poses a major threat to the global poultry industry. In this study, we identified and characterized a novel field IBDV strain NN040124, which exhibits both reassortment and recombination features. Genotyping identified …

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Chicken caspase-3 promotes IBDV replication via the cleavage of IRF7

Yang Chen, Jie Chen, Yanhua Xiang, Simin Wei et autres

Infectious bursal disease virus (IBDV) is a highly contagious pathogen that causes severe immunosuppression in chickens, leading to significant economic losses. While apoptosis is a critical host defense mechanism, many viruses exploit it to enhance replication. Here, we demonstrate that IBDV infection …

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Advances in Infectious Bursal Disease Virus Vaccines—A Review

Weiwei Wang, Jia‐Feng Wu, Nansong Jiang, Qizhang Liang et autres

Infectious Bursal Disease (IBD) is an immunosuppressive viral disease caused by the Infectious Bursal Disease Virus (IBDV). It primarily affects young chickens, targeting the bursa of Fabricius, and poses significant economic threats to the poultry industry. To date, in addition to strict …

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Infectious bursal disease virus affecting interferon regulatory factor 7 signaling through VP3 protein to facilitate viral replication

Zhiyuan Wang, Yanyan Chen, Rui Chen, Weiwei Wang et autres

Interferon regulatory factor 7 (IRF7)-mediated type I interferon antiviral response is crucial for regulating the host following viral infection in chickens. Infectious bursal disease virus (IBDV) is a double-stranded RNA virus that induces immune suppression and high mortality rates in chickens aged …

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Rapid identification, pathotyping and quantification of infectious bursal disease virus by high-resolution melting curve quantitative reverse transcription PCR analysis: An innovative technology well-suited for real-time large-scale epidemiological surveillance

Weiwei Wang, Yan Zhang, Wenbo Zuo, Yuanzheng Qiao et autres

With the virus continuing to evolve, very virulent IBDV (vvIBDV) and novel variant IBDV (nvIBDV) have become the predominant epidemic strains in China, exacerbated by the widespread use of attenuated vaccine strains (attIBDV), making a complex infection situation of IBDV in the …

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The complete protections induced by the oil emulsion vaccines of the novel variant infectious bursal disease viruses against the homologous challenges indicating the important roles of both VP2 and VP1 in the antigenicity and pathogenicity of the virus

Weiwei Wang, Yu Huang, Yan Zhang, Yuanzheng Qiao et autres

Novel variant infectious bursal disease virus (nvIBDV) is an emerging genotype (A2dB1b) that can cause severe and prolonged immunosuppression in young chickens. Despite current commercial vaccines being proven to lack complete protection against nvIBDV, it remains unclear whether the oil emulsion inactivated …

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Cryptococcus neoformans trehalose-6-phosphate synthase (tps1) promotes organ-specific virulence and fungal protection against multiple lines of host defenses

Kristie D. Goughenour, Arianna Creech, Jintao Xu, Xiumiao He et autres

Trehalose-6-phosphate synthase (TPS1) was identified as a virulence factor for Cryptococcus neoformans and a promising therapeutic target. This study reveals previously unknown roles of TPS1 in evasion of host defenses during pulmonary and disseminated phases of infection. In the pulmonary infection model, …

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RNA-seq reveals role of cell-cycle regulating genes in the pathogenicity of a field very virulent infectious bursal disease virus

Weiwei Wang, S. Li, Zhiyuan Wang, Wenbo Zuo et autres

Infectious bursal disease virus (IBDV) infection causes highly contagious and immunosuppressive disease in poultry. The thymus, serving as the primary organ for T cell maturation and differentiation, plays an important role in the pathogenicity of IBDV in the infected chickens. However, there …

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Genetic and pathogenic characterizations of a naturally occurring reassortant and homologous recombinant strain of the classical infectious bursal disease virus re-emerging in chickens in southern China

Weiwei Wang, Jun Shi, Yan Zhang, Yuanzheng Qiao et autres

Infectious bursal disease (IBD) classical virus strain (cIBDV) can cause morbidity and mortality in young chickens with severe long-term immunosuppression. However, since the emergence and widespread prevalence of very virulent strain (vvIBDV) in China from 1991, reports of cIBDV have become rare. …

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Analysis of the global origin, evolution and transmission dynamics of the emerging novel variant IBDV (A2dB1b): The accumulation of critical aa‐residue mutations and commercial trade contributes to the emergence and transmission of novel variants

Weiwei Wang, Xiumiao He, Yan Zhang, Yuanzheng Qiao et autres

The Chinese IBDV novel variant (nvIBDV), belonging to the genotype A2dB1b, an emerging pathotype that can cause subclinical disease with severe, prolonged immunosuppression, poses a new threat to the poultry industry. The process of the global origin, evolution and transmission dynamics of …

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Differential Modulation of Innate Antiviral Profiles in the Intestinal Lamina Propria Cells of Chickens Infected with Infectious Bursal Disease Viruses of Different Virulence

Rui Chen, Yanhua Xiang, Yanyan Chen, Weiwei Shen et autres

Infectious bursal disease virus (IBDV) is one of the most important infectious diseases of poultry around the world. Gut-associated lymphoid tissues (GALT) are the first line of defense of the host against the infection. The purpose of this study was to investigate …

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Corrigendum to “Transcriptome analysis reveals possible antitumor mechanism of Chlorella exopolysaccharide” [Gene 779 (2021) 145494]

Run Zhong, Jieqiong Li, Siwei Wu, Xiumiao He et autres

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