Xin‐Yuan Sun

A new record of late Permian (Wuchiapingian) ammonoid Stacheoceras from an exotic limestone block in the Yarlung-Zangbo Suture Zone, South Xizang (Tibet), China

Xin‐Yuan Sun, Xu Dai, X K Liu, Jiang Shou-yi et autres

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Natural functional sweet-tasting molecules from food-medicine plants: an updated review of their sources and classifications, sensory evaluation, mechanism of sweet taste transduction and safety

Kangmeng Sun, Jiayi Liang, Xin Luan, Xin‐Yuan Sun et autres

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Sodium hexametaphosphate mitigates calcium oxalate stone formation by modulating crystallization and maintaining PPARα signaling

Jun-Yi Xian, Peng Lei, Jun Long, Xuewu Chen et autres

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Symmetric brain-liver circuits mediate lateralized regulation of hepatic glucose output in mice

Zhonglong Wang, Xiangfei Gong, Li Jiang, Ke Wang et autres

Abstract Neural lateralization is well recognized in the control of contralateral somatic movement, yet its relevance to visceral organ regulation remains poorly understood. This study aimed to determine whether the central nervous system exerts lateralized control over hepatic glucose metabolism and to …

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Galnt2 neurons in the ventromedial hypothalamus counterregulate hypoglycemia via a brain-liver neurocircuit

Junjie Wang, Xin‐Yuan Sun, Xiangfei Gong, Wenling Dai et autres

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Therapeutic potential of Desmodium styracifolium polysaccharide in attenuating nano-calcium oxalate induced renal injury and fibrosis

Bang‐Xian Yu, Jun Long, Quan Zhang, Yang Liu et autres

Calcium salt deposition in the kidney induces epithelial-to-mesenchymal transition (EMT) in renal tubular epithelial cells, which is the pathological basis for the progression to renal fibrosis in patients with renal stones; however, effective drugs to prevent and treat this disease have not …

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Gut microbiota-regulated unconjugated bilirubin metabolism drives renal calcium oxalate crystal deposition

Shujue Li, Wenzheng Wu, Yuhao Zhou, Shike Zhang et autres

Gut microbial dysbiosis and the resultant metabolic disorder are intimately associated with calcium oxalate (CaOx) stone formation. Renal CaOx crystal deposition is one of the primary initiating factors of CaOx formation; however, the critical signaling metabolites communicating along the gut-kidney axis, and …

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Structural characterization of polysaccharides from Lygodium japonicum (Thunb.) Sw. and its inhibition ability in calcium oxalate renal stone

Chun-Yao Li, Quan Zhang, Xinyu Shi, Jun Long et autres

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An Ultrasmall Self‐Assembled Gallic‐Acid‐Based Natural Multifunctional Defense Networks for Therapeutic Application in Calcium Oxalate Nephropathies

Quan Zhang, Bang‐Xian Yu, Jun Long, Xuewu Chen et autres

Abstract Kidney stones, which have high prevalence and recurrence rates, often cause severe oxidative damage and inflammation. The ultrasmall hydrodynamic diameter of nanoparticles is crucial for their enrichment in the kidneys to exert biological activity. However, integrating crystallization inhibition and therapeutic functions …

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Gut microbiota modulation via fecal microbiota transplantation mitigates hyperoxaluria and calcium oxalate crystal depositions induced by high oxalate diet

Lingyue An, Shujue Li, Zhenglin Chang, Min Lei et autres

Hyperoxaluria, including primary and secondary hyperoxaluria, is a disorder characterized by increased urinary oxalate excretion and could lead to recurrent calcium oxalate kidney stones, nephrocalcinosis and eventually end stage renal disease. For secondary hyperoxaluria, high dietary oxalate (HDOx) or its precursors intake …

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A pH-responsive PROTAC-based nanosystem triggers tumor-specific ferroptosis to construct in situ tumor vaccines

Linghong Huang, Xin‐Yuan Sun, Qinhua Zuo, Ting Song et autres

served as an adjuvant to promote the maturation and cross-presentation of APCs. Together with the PD1 antibody, this further enhanced the anti-tumor response of the in situ tumor vaccine and reversed the suppressive immune microenvironment. This antigen capture system provides a novel …

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Author response for "Sulfated Undaria pinnatifida polysaccharides inhibit kidney stone formation through crystalline modulation and relieving cellular oxidative damage and inflammation"

Xuewu Chen, Jun Long, Quan Zhang, Linghong Huang et autres