Madeleine Julie Oudin

Targeting fibroblast activation suppresses chemotherapy-induced pro-invasive remodeling of the extracellular matrix

Anna Yui, Liyi Peng, Katie C. Lew, Dylan J. Landau et autres

Abstract Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that accounts for nearly 20% of breast cancer diagnoses. Despite recent approvals of novel therapeutic agents for TNBC, neoadjuvant chemotherapy remains part of standard of care treatment for TNBC patients. …

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Cell-line specific role of Cathepsin B in triple-negative breast cancer growth, invasion and response to chemotherapy

Charlotte Kelley, Justinne R. Guarin, Emily Henrich, Jackson P. Fatherree et autres

Cathepsins are papain-family cysteine proteases known to play a cell-intrinsic role in protein degradation in the lysosome, as well as in digesting ECM and surface proteins after being secreted. Both of these functions are known to mediate pro-tumorigenic effects of CTSB in …

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A splice-switching antisense oligonucleotide approach for pediatric genetic epilepsies

Haley B. Dame, Hema Kopalle, Belén Miñana, Zin‐Juan Klaft et autres

Summary Paragraph Variants in ion channel genes are common causes of pediatric epilepsy, often leading to intractable seizures, developmental delay and other comorbidities, which increases risk of death. Pathogenic variants in the SCN8A gene, which encodes a voltage-gated sodium channel critical for …

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Entangled cellular and molecular relationships at the sensory neuron-cancer interface

Debpali Sur, Yi Zeng, Hiroki Hill Kobayashi, Xiaofei Zhi et autres

Entangled cellular and molecular relationships at the sensory neuron-cancer interface

Debpali Sur, Yi Zeng, Hiroki Hill Kobayashi, Xiaofei Zhi et autres

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A research roadmap for SCN8A-related disorders: addressing knowledge gaps and aligning research priorities across stakeholders

Anne T. Berg, Christopher B. Burge, Gabi Conecker, Dylann Cordova-Martinez et autres

BACKGROUND: Despite significant scientific progress since the 2012 discovery that variants in the SCN8A gene can cause human epilepsy, disease mechanisms and best practices for management of SCN8A-related disorders (SCN8A-RD) remain incompletely understood. To accelerate the rate of progress, the International SCN8A …

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Triple-Negative Breast Cancer Cells Activate Sensory Neurons via TRPV1 to Drive Nerve Outgrowth and Tumor Progression

Hanan Bloomer, Savannah R. Parker, Wesley P. Clawson, M. Caron et autres

Abstract The tumor microenvironment in triple-negative breast cancer (TNBC) is characterized by increased sensory nerve density, which contributes to cancer progression by promoting migration and metastasis. However, the origin of tumor-innervating nerves and the mechanisms driving sensory innervation into tumors remain poorly …

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Investigation of TNBC metastatic potential following synergistic photodynamic therapy and chemotherapy

Jeanne Duong, Rachel A. McGinn, Nashielli Diaz, Deepti H. Srinivasan et autres

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer due to a lack of targetable receptors and a high rate of metastasis. The current standard of care for TNBC involves neoadjuvant chemotherapy, such as doxorubicin (DOX), a systemic intervention …

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Neuronal mimicry in tumors: lessons from neuroscience to tackle cancer

Hanan Bloomer, Haley B. Dame, Savannah R. Parker, Madeleine Julie Oudin

Cellular plasticity and the ability to avoid terminal differentiation are hallmarks of cancer. Here, we review the evidence that tumor cells themselves can take on properties of neurons of the central nervous system, which can regulate tumor growth and metastasis. We discuss …

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Cenobamate as add‐on treatment for SCN8A developmental and epileptic encephalopathy

Cathrine Elisabeth Gjerulfsen, Madeleine Julie Oudin, Francesca Furia, Sopio Gverdtsiteli et autres

OBJECTIVES: Developmental and epileptic encephalopathies (DEEs) caused by pathogenic variants in SCN8A are associated with difficult-to-treat and early-onset seizures, developmental delay/intellectual disability, impaired quality of life, and increased risk of early mortality. High doses of sodium channel blockers are typically used to …

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Human Retinal Progenitor Cell (hRPC) Migration in Three‐Dimensional (3D) Environments of Varying Stiffness and Composition

J. K. Kundu, Douglas Blanton, Mahboobeh Rezaeeyazdi, Madeleine Julie Oudin et autres

Retinal degeneration is the leading cause of blindness worldwide. Subretinal implantation of human retinal progenitor cells (hRPCs) has shown great promise in models of retinal degeneration for restoration of vision but is limited by extremely low (< 2%) integration into the retina. …

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Cenobamate as add-on treatment for SCN8A developmental and epileptic encephalopathy

Cathrine Elisabeth Gjerulfsen, Madeleine Julie Oudin, Francesca Furia, Sopio Gverdtsiteli et autres

Abstract Objectives Developmental and epileptic encephalopathies (DEEs) caused by pathogenic variants in SCN8A are associated with difficult-to-treat and early-onset seizures, developmental delay/intellectual disability, impaired quality of life, and increased risk of early mortality. Commonly used antiseizure medications (ASMs) for SCN8A- related disorders, …

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