Katrin Weidenbach

Phosphate backbone epitranscriptomics: Discovery of natural RNA phosphorothioates and their writer machinery

Alexander Maman, Yuko Nobe, Kristin A. Fluke, Katrin Weidenbach et autres

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Guided tour through the small protein landscape of Methanosarcina mazei using proteomics and biochemical approaches

Eva Herdering, Liam Cassidy, Philipp T. Kaulich, Jürgen Bartel et autres

Abstract Small open reading frame (small ORF) encoded proteins fulfil important roles in many cellular processes. In the methanoarchaeon Methanosarcina mazei, numerous small proteins have previously been identified under different nitrogen-availabilities, with only few being subject to functional characterization. Consequently, a detailed …

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Small protein mediates inhibition of ammonium transport in Methanosarcina mazei —an ancient mechanism?

Tim Habenicht, Katrin Weidenbach, Adrián Velázquez‐Campoy, Rubén M. Buey et autres

ABSTRACT In the past decade, small open reading frames (sORFs) coding for proteins less than 70 amino acids (aa) in length have moved into the focus of science. sORFs and the corresponding small proteins have been recently identified in all three domains …

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The power of the small: the underestimated role of small proteins in bacterial and archaeal physiology

Britta Jordan, Katrin Weidenbach, Ruth A. Schmitz

Small proteins encoded by small open-reading frames (sORFs) (≤70 aa) were overlooked for decades due to methodological reasons and are thus often missing in genome annotations. Novel detection methods such as ribosome profiling (Ribo-Seq) and mass spectrometry optimized for small proteins (peptidomics) …

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Small protein mediates inhibition of ammonium transport in Methanosarcina mazei – an ancient mechanism?

Tim Habenicht, Katrin Weidenbach, Adrián Velázquez‐Campoy, Rubén M. Buey et autres

Abstract In the past decade, small open reading frames (sORFs) coding for proteins less than 70 amino acids (aa) in length have moved into the focus of Science. sORFs and corresponding small proteins have been recently identified in all three domains of …

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Artefactual source of 2-hydroxypyridine

Paul Wilmes, Jean‐Pierre Trezzi, Velma T. E. Aho, Christian Jäger et autres

Abstract As part of the revisions of our original manuscript, we performed 13C-labelling experiments with cultures of the microorganism most strongly correlated with 2-hydroxypyridine (2-HP), i.e. the archaeal species Methanobrevibacter smithii. Although unlabelled 2-HP was detected in the cultures, the measurements by …

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Newly Established Genetic System for Functional Analysis of MetSV

Finn O. Gehlert, Katrin Weidenbach, Brian Barüske, Daniela Hallack et autres

The linear chromosome of the Methanosarcina spherical virus with 10,567 bp exhibits 22 ORFs with mostly unknown functions. Annotation using common tools and databases predicted functions for a few genes like the type B DNA polymerase (MetSVORF07) or the small (MetSVORF15) and …

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Dual-RNAseq Analysis Unravels Virus-Host Interactions of MetSV and Methanosarcina mazei

Finn O. Gehlert, Till Sauerwein, Katrin Weidenbach, Urška Repnik et autres

Methanosarcina spherical virus (MetSV), infecting Methanosarcina species, encodes 22 genes, but their role in the infection process in combination with host genes has remained unknown. To study the infection process in detail, infected and uninfected M. mazei cultures were compared using dual-RNAseq, …

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An archaeal compound as a driver of Parkinson’s disease pathogenesis

Paul Wilmes, Jean‐Pierre Trezzi, Velma T. E. Aho, Christian Jäger et autres

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Erratum for Monsees et al., “Label-Free Raman Microspectroscopy for Identifying Prokaryotic Virocells”

Indra Monsees, Victoria Turzynski, Sarah P. Esser, André Soares et autres

CA Monsees CA Probst

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Label-Free Raman Microspectroscopy for Identifying Prokaryotic Virocells

Indra Monsees, Victoria Turzynski, Sarah P. Esser, André Soares et autres

Viruses are highly diverse biological entities shaping many ecosystems across Earth. However, understanding the infection of individual microbial cells and the related biochemical changes remains limited. Using Raman microspectroscopy in conjunction with univariate and multivariate statistics, we established a marker for identification …

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Genetic Methods and Construction of Chromosomal Mutations in Methanogenic Archaea

Johanna Thomsen, Katrin Weidenbach, William W. Metcalf, Ruth A. Schmitz

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