Hannah R. Mathieson

Age, anticoagulants, hypertension and cardiovascular genetic traits predict cranial ischaemic complications in patients with giant cell arteritis

Natalie Chaddock, Charlotte J. Harden, Louise Sørensen, Hannah R. Mathieson et autres

Objectives This project aimed to determine whether cranial ischaemic complications at the presentation of giant cell arteritis (GCA) were associated with pre-existing cardiovascular (CV) risk factors, CV disease or genetic risk of CV-related traits. Methods 1946 GCA patients with clinicodemographic data at …

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Polymyalgia rheumatica shows metabolomic alterations that are further altered by glucocorticoid treatment: Identification of metabolic correlates of fatigue

Julia E. Manning, Emma L. Harris, Hannah R. Mathieson, Louise Sørensen et autres

In polymyalgia rheumatica (PMR), glucocorticoids (GCs) relieve pain and stiffness, but fatigue may persist. We aimed to explore the effect of disease, GCs and PMR symptoms in the metabolite signatures of peripheral blood from patients with PMR or the related disease, giant …

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Subjective loss of clinical response to TNFi in axSpA relates to recurrence of MRI bone marrow oedema particularly with long-acting agents

Stephanie Rose Harrison, Rebecca Ansell, Hannah R. Mathieson, Mira Merashli et autres

OBJECTIVES: Subjective loss of response immediately prior to routine TNFi therapy can occur in axial spondyloarthritis (axSpA). We investigated clinical outcomes in patients taking the first three licenced TNFis and correlated this with recurrence of MRI bone marrow oedema (MRI-BMO). METHODS: Proof-of-concept …

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Combined inhibition of tumour necrosis factor-alpha and interleukin-12/23 for long-standing, refractory psoriatic disease: a differential role for cytokine pathways?

Gabriele De Marco, Dennis McGonagle, Hannah R. Mathieson, Mira Merashli et autres

We hypothesize a differential cutaneous/articular cytokine hierarchy in a subset of psoriatic disease cases. Sir, PsA and psoriasis are closely related chronic inflammatory conditions leading to multi-tissue involvement. Polymorphisms in genes regulating TNFα and the IL-23 and -17 (IL-23/17) axis are risk …

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Assessment of two screening tools to identify psoriatic arthritis in patients with psoriasis

Laura C. Coates, Laura J. Savage, Hector Chinoy, Philip Laws et autres

BACKGROUND: Many patients with psoriasis have undiagnosed psoriatic arthritis. Low specificity is found with many PsA screening tools. A new instrument, the CONTEST questionnaire, was developed utilizing the most discriminative items from existing instruments. OBJECTIVE: The aim of this study was to …

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THU0368 Clinical and imaging characteristics of patients with axial spondyloarthritis reporting flare symptoms immediately prior to next dose in routine tnfi therapy

Rebecca Ansell, Hannah R. Mathieson, Mira Merashli, Noemi Busquets-Pérez et autres

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Poor awareness of inflammatory back pain and axial spondyloarthritis among secondary care specialists

Hannah R. Mathieson, Mira Merashli, Karl Gaffney, Helena Marzo‐Ortega

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E72 Awareness of Inflammatory Back Pain and Axial Spondyloarthopathy in Secondary Care

Hannah R. Mathieson, Mira Merashli, Karl Gaffney, Helena Marzo‐Ortega

Disclosure statement: H.R.M. has received research funding from Pfizer. K.G. has received consultancy fees/and or research funding from AbbVie, UCB, Pfizer, MSD and Novartis. H.M.O. has received honoraria or research grants from AbbVie, Celgene, Jansen, MSD, Novartis, Pfizer and UCB. The other …

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Axial spondyloarthritis: diagnosis and management

Hannah R. Mathieson, Helena Marzo‐Ortega

Primary care plays a vital role in the identification and early referral of axial spondyloarthritis. Here, the authors discuss how to recognise the signs and recommend a multidisciplinary approach to management.

Diurnal variation of gait in patients with rheumatoid arthritis: The DIVIGN study

Michael Ross Backhouse, David A. Pickles, Hannah R. Mathieson, Lucy Edgson et autres

BACKGROUND: Circadian variation of joint stiffness (morning stiffness) and its impact on functional ability are widely recognised in rheumatoid arthritis. Subsequent within-day variation of walking ability is important due to the increased availability of instrumented gait analysis. This study aimed to quantify …

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Basic Science * 208. Stem Cell Factor Expression is Increased in the Skin of Patients with Systemic Sclerosis and Promotes Proliferation and Migration of Fibroblasts in vitro

Sarah Karrar, Shiwen Xu, Joanne Nikotorowicz-Buniak, David Abraham et autres

Background: Previous research has suggested that the severity of RA has decreased over time. This study examines the pattern of disease severity in patients with inflammatory polyarthritis (IP) at time of registration into the Norfolk Arthritis Register (NOAR). Methods: NOAR is a …

A pilot study of the effect of a nutrition education programme on the nutrition knowledge and practice of nurses

Sean O’Mahony, J. Hutchinson, Athena McConnell, Hannah R. Mathieson et autres

Background: The Royal College of Nursing (RCN) recognises the key role that nurses play in the identification and management of nutritional issues as they have the most frequent contact with patients(Green & Watson, 2007). However, it has been suggested that under-nutrition is …

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