Charlotte J. Harden

Optimization of SARS-CoV-2 culture from clinical samples for clinical trial applications

Dominic Wooding, Kate Buist, Alessandra Romero-Ramirez, Helen R. Savage et autres

Clinical trials of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) therapeutics often include virological secondary endpoints to compare viral clearance and viral load reduction between treatment and placebo arms. This is typically achieved using quantitative reverse-transcriptase PCR (RT-qPCR), which cannot differentiate replicant …

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Age, anticoagulants, hypertension and cardiovascular genetic traits predict cranial ischaemic complications in patients with giant cell arteritis

Natalie Chaddock, Charlotte J. Harden, Louise Sørensen, Hannah R. Mathieson et autres

Objectives This project aimed to determine whether cranial ischaemic complications at the presentation of giant cell arteritis (GCA) were associated with pre-existing cardiovascular (CV) risk factors, CV disease or genetic risk of CV-related traits. Methods 1946 GCA patients with clinicodemographic data at …

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Histopathology reporting of temporal artery biopsy specimens for giant cell arteritis: results of a modified Delphi study

Dilek Taze, Arundhati Chakrabarty, Ranjana Venkateswaran, Collette Hartley et autres

The temporal artery biopsy (TAB) is regarded as the gold-standard test in the diagnosis of giant cell arteritis (GCA). There is a lack of agreement among experienced pathologists regarding the diagnostic features and classification of inflammation observed in TAB sections in the …

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Multicenter Diagnostic Evaluation of OnSite COVID-19 Rapid Test (CTK Biotech) among Symptomatic Individuals in Brazil and the United Kingdom

Caitlin R. Thompson, Pablo Munoz Torres, Konstantina Kontogianni, Rachel L. Byrne et autres

Evaluating rapid diagnostic tests in diverse populations is essential to improving diagnostic responses as it gives an indication of the accuracy in real-world scenarios. In the case of rapid diagnostic testing within this pandemic, lateral flow tests that meet the minimum requirements …

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A high-resolution melt curve toolkit to identify lineage-defining SARS-CoV-2 mutations

Alice J. Fraser, Caitlin Greenland-Bews, Daniel F. Kelly, Christopher T. Williams et autres

The emergence of severe acute respiratory syndrome 2 (SARS-CoV-2) variants of concern (VOCs), with mutations linked to increased transmissibility, vaccine escape and virulence, has necessitated the widespread genomic surveillance of SARS-CoV-2. This has placed a strain on global sequencing capacity, especially in …

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Multicenter Diagnostic Evaluation of a Novel Coronavirus Antigen Lateral Flow Test among Symptomatic Individuals in Brazil and the United Kingdom

Débora Souza Faffe, Rachel L. Byrne, Richard Body, Terezinha Marta Pereira Pinto Castiñeiras et autres

Since the beginning of the SARS-CoV-2 pandemic, we have witnessed growing numbers of antigen rapid diagnostic tests (Ag-RDTs) being brought to market. In the United Kingdom, this was somewhat controlled indirectly as the government offered free tests from a small number of …

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Temporal artery biopsy: audit of histological diagnosis

Arundhati Chakrabarty, Sarah Mackie, Charlotte J. Harden, Ann Wendy Morgan

Sir, Although temporal artery biopsy (TAB) may be considered a gold standard for the diagnosis of GCA, there is significant debate over how accurately a definitive diagnosis can be made from TAB alone. Furthermore, the Role of Ultrasound Compared to Biopsy of …

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010 Temporal artery biopsy: audit, scoring and reporting

Arundhati Chakrabarty, Sarah Mackie, Charlotte J. Harden, Ann Wendy Morgan

Background: Although temporal artery biopsy (TAB) may be considered a gold standard for the diagnosis of giant cell arteritis (GCA), in histopathology there is much debate over how accurately a clear diagnosis can be made. There have been no clinical audits to …

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102. PROPOSAL FOR A SYNOPTIC SYSTEM FOR REPORTING OF TEMPORAL ARTERY BIOPSIES

Sarah Mackie, Aruna Chakrabarty, Charlotte J. Harden, Ann Wendy Morgan

Background: Access to tocilizumab for UK patients with giant cell arteritis (GCA) requires a case review and diagnostic confirmation by regional centres. We investigated consistency of reporting between different pathologists, and propose a solution. Methods: (1) An audit of UK pathologists was …

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Systematic literature review shows that appetite rating does not predict energy intake

Guy M. Holt, Lauren Owen, Sophie Till, Yanying Cheng et autres

Ratings of appetite are commonly used to assess appetite modification following an intervention. Subjectively rated appetite is a widely employed proxy measure for energy intake (EI), measurement of which requires greater time and resources. However, the validity of appetite as a reliable …

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Systematic literature review shows that appetite rating does not predict energy intake

Guy M. Holt, Lauren Owen, Sophie Till, Yanying Cheng et autres

Ratings of appetite are commonly used to assess appetite modification following an intervention. Subjectively rated appetite is a widely employed proxy measure for energy intake (EI), measurement of which requires greater time and resources. However, the validity of appetite as a reliable …

Systematic Literature Review Shows That Appetite Rating does Not Predict Energy Intake

Guy M. Holt, Lauren Owen, Sophie Till, Yanying Cheng et autres

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