Huang‐Kai Kao

Probiotics and Extracellular Vesicles as Redox Modulators in Wound Healing: From Microbial Therapeutics to Engineered Nanotherapeutic Strategies

Aline Yen Ling Wang, Ana Elena Aviña, Jerry Tsing-Kai Lin, Yen‐Yu Liu et autres

Chronic wounds are characterized by prolonged inflammation, excess oxidative stress, unregulated angiogenesis, and faulty tissue regeneration that are associated with slow wound healing and poor clinical outcomes. Reactive oxygen species (ROS) signaling deregulation is involved in the pathway of chronic wound pathophysiology, …

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Occurrence, Risk Factors, and Early Clinical Outcomes of Dysphagia on Postoperative Day 7 in Patients With Oral Cancer Undergoing Free‐Flap Reconstruction Surgery: A Hospital‐Based Retrospective Study

Wen‐Pin Yu, Hui‐Mei Han, Huang‐Kai Kao, Hsiao‐Yean Chiu

BACKGROUND: Dysphagia is common in patients with oral cancer undergoing flap reconstruction surgery. Surgical resection and reconstruction can affect the sensory and motor functions associated with swallowing. Studies on dysphagia have not investigated patients with oral cancer undergoing flap reconstruction surgery. In …

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Microbial allies in skin trauma recovery: from immune modulation to engineered probiotic therapeutics

Aline Yen Ling Wang, Ana Elena Aviña, Yen‐Yu Liu, Huang‐Kai Kao

Abstract Research shows that the microbiome of the skin is present as an active contributor to wound healing processes by moving past its historical infection-related function. The review investigates how commensal and probiotic bacteria affect immunomodulation while accelerating epithelial growth, together with …

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Artificial intelligence outperforms a nomogram for osteoradionecrosis prognostication following fibula free flap reconstruction in oral cancer patients

Dany Y. Matar, Gina Alicia Mackert, Anthony Y. Matar, Angela Chien-Yu Chen et autres

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PS11.5: Globo H ceramide promotes retention and quality of tissue stromal vascular fraction graft.

Hui-Yun Cheng, Jing‐Yan Cheng, Jung‐Tung Hung, Gonzalo Mallarino Restrepo et autres

Background: Fat grafting is widely utilized in plastic surgery; however, inconsistent graft retention remains a key clinical issue. One major limitation is the poor ischemic tolerance of transplanted adipose tissue, aiming to timely improving the vascularity of the grafted fat. Among various …

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Incidence and Risk of Occult Cancer in Advanced-Stage Mandibular Osteoradionecrosis

Hanpon Klibngern, Shao‐Yu Hung, Chung‐Kan Tsao, Huang‐Kai Kao et autres

BACKGROUND: Advanced mandibular osteoradionecrosis (ORN) often requires segmental resection and reconstruction. Although ORN has distinct clinical and radiographic features, detecting occult cancer preoperatively remains challenging. The goal of this study was to determine the incidence and risk factors of occult cancer in …

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Enhancing retention and quality of tissue stromal vascular fraction graft with globo H ceramide

Jing‐Yan Cheng, Hui-Yun Cheng, Jung‐Tung Hung, Gonzalo Mallarino Restrepo et autres

Fat grafting has been extensively used in plastic surgery practice, yet unstable retention in the recipient site remains a significant clinical challenge. The limited tolerance of injected adipose tissue to ischemia has prompted strategies aiming at timely enhancing the vascularity of the …

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Stromal vascular fraction in canine osteoarthritis: advantages, applications, and insights for veterinary practitioners

Aline Yen Ling Wang, Ana Elena Aviña, Yen‐Yu Liu, Huang‐Kai Kao

Canine osteoarthritis (OA) stands as a prevalent and excruciating joint condition that represents a promising application of stromal vascular fraction (SVF) treatment. In this review, we discuss the multi-factorial advantage of SVF cited as anti-inflammatory, regenerative, and angiogenic, all of which improve …

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An Adipose-Derived Stem Cell Exosome Sheet Promotes Oral Mucosal Wound Healing

Dany Y. Matar, Adriana Christine Panayi, Dennis Paul Orgill, Huang‐Kai Kao

Objective: Oral mucosal wound healing is not completely understood, and effective therapies are lacking. This study explores the potential of an adipose-derived stem cell (ADSC) exosome sheet in enhancing intraoral wound healing in rats. Approach: An ADSC exosome sheet derived from Tisseel …

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76. An Adipose Stem Cell Derived Exosome Sheet Regulates Oral Mucosal Wound Healing

Dany Y. Matar, Chung‐Jan Kang, Adriana Christine Panayi, Dennis Paul Orgill et autres

PURPOSE: Wounds in the oral cavity, whether caused by surgery or trauma, can lead to significant health and economic burdens. While the mechanisms of cutaneous wound healing are well-established, intraoral mucosal healing remains less explored, making treatment development more challenging. Adipose-derived stem …

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162. Iron-Based Metal-Organic Framework MIL-100(Fe) Modulates Keloid Scarring

Dany Y. Matar, Po-Hsiu Cheng, Wei-Ting Chung, Adriana Christine Panayi et autres

PURPOSE: Pathological scarring such as keloids poses significant therapeutic challenges due to their complex pathophysiology, often resulting in substantial functional impairments and aesthetic concerns. Metal-Organic Frameworks (MOFs), specifically MIL-100(Fe), have emerged as a promising treatment modality for keloid scars. This study aims …

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Pluripotent Stem Cells: Recent Advances and Emerging Trends

Aline Yen Ling Wang, Ana Elena Aviña, Yen‐Yu Liu, Huang‐Kai Kao

The field of induced pluripotent stem cells (iPSCs) continues to evolve, offering unprecedented potential for regenerative medicine, disease modeling, and therapeutic applications [...].

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