Hui-Yun Cheng

Adipose-derived therapeutics for radiation-induced injury and fibrosis: mechanistic and preclinical evidence

C. Javier Solorza, Hui-Yun Cheng

Abstract Background Radiotherapy (RT) is an essential component of modern cancer treatment but often injures adjacent healthy tissues, leading to acute radiation dermatitis and chronic radiation-induced fibrosis (RIF), a progressive condition characterized by persistent inflammation, vascular rarefaction, excessive extracellular matrix (ECM) deposition, …

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PS11.5: Globo H ceramide promotes retention and quality of tissue stromal vascular fraction graft.

Hui-Yun Cheng, Jing‐Yan Cheng, Jung‐Tung Hung, Gonzalo Mallarino Restrepo et autres

Background: Fat grafting is widely utilized in plastic surgery; however, inconsistent graft retention remains a key clinical issue. One major limitation is the poor ischemic tolerance of transplanted adipose tissue, aiming to timely improving the vascularity of the grafted fat. Among various …

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Characterizing Donor- and Recipient-Derived Macrophages in Vascularized Composite Allotransplantation Rejection

Hui-Yun Cheng, Chun‐Chi Lin, S. Liu, Madonna Rica Anggelia

Purpose: It has been reported that macrophages are accumulated within the graft during vascularized composite allotransplantation (VCA) rejection, however, the specific processes that macrophages participate are not fully characterized. In particular, the presence and function of donor-derived macrophages are worthy of further …

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Enhancing retention and quality of tissue stromal vascular fraction graft with globo H ceramide

Jing‐Yan Cheng, Hui-Yun Cheng, Jung‐Tung Hung, Gonzalo Mallarino Restrepo et autres

Fat grafting has been extensively used in plastic surgery practice, yet unstable retention in the recipient site remains a significant clinical challenge. The limited tolerance of injected adipose tissue to ischemia has prompted strategies aiming at timely enhancing the vascularity of the …

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Unraveling the Roles of Macrophages in Vascularized Composite Allotransplantation

Hui-Yun Cheng, Madonna Rica Anggelia, Cheng‐Hung Lin

The phenotypic heterogeneity and functional diversity of macrophages have been increasingly appreciated, particularly regarding their roles as innate immune cells in shaping transplantation outcomes. However, their functions in vascularized composite allotransplantation (VCA) remain underexplored. In this review, we first describe the development …

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Single injection of tacrolimus-loaded thermosensitive hydrogel improves outcomes in vascularized composite allotransplantation

Madonna Rica Anggelia, Hsiu-Chao Lin, Chih-Chi Cheng, Yun‐Huan Hsieh et autres

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P.545: Deciphering the interplay of lymph node profiles with outcomes in vascularized composite allotransplantation.

Hui-Yun Cheng, Madonna Rica Anggelia, C.H. Lin, Shiao-Chin Liu et autres

Background: As crucial secondary lymphoid organs located at the kunction between allograft and host, the complex cellular and molecular processes within lymph nodes (LNs) following vascularized composite allotransplantation (VCA) are poorly understood. Additionally, the connection between these processes and the eventual outcome …

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Enhancing Immunomodulatory Function of Mesenchymal Stromal Cells by Hydrogel Encapsulation

Hui-Yun Cheng, Madonna Rica Anggelia, Shiao-Chin Liu, Chih-Fan Lin

Mesenchymal stromal cells (MSCs) showcase remarkable immunoregulatory capabilities in vitro, positioning them as promising candidates for cellular therapeutics. However, the process of administering MSCs and the dynamic in vivo environment may impact the cell-cell and cell-matrix interactions of MSCs, consequently influencing their …

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Toward transplantation tolerance with adipose tissue-derived therapeutics

Hui-Yun Cheng, Madonna Rica Anggelia, Cheng‐Hung Lin, Fu‐Chan Wei

Solid organ and composite tissue allotransplanation have been widely applied to treat end-stage organ failure and massive tissue defects, respectively. Currently there are a lot of research endeavors focusing on induction of transplantation tolerance, to relieve the burden derived from long-term immunosuppressant …

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Reciprocal Donor-Recipient Strain Combinations Present Different Vascularized Composite Allotransplantation Outcomes in Rodent Models

Hui-Yun Cheng, Chih-Fan Lin, Madonna Rica Anggelia, Ping‐Chin Lai et autres

BACKGROUND: Although vascularized composite allotransplantation (VCA) has been the focus of many animal studies, further research is needed to determine the potential for a generalized model and immunosuppression regimen that applies across different donor-recipient combinations. In this study, the authors evaluated the …

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The intragraft vascularized bone marrow induces secondary donor-specific mystacial pad allograft tolerance

Cheng‐Hung Lin, Madonna Rica Anggelia, Hui-Yun Cheng, Yun‐Huan Hsieh et autres

Introduction Vascularized bone marrow (VBM) is essential in tolerance induction through chimerism. We hypothesized that the inclusion of VBM contributes to the induction of mystacial pad allotransplantation tolerance. Method In this study, 19 VBM, nine mystacial pad, and six sequential VBM and …

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Implantable Immunosuppressant Delivery to Prevent Rejection in Transplantation

Madonna Rica Anggelia, Ren‐Wen Huang, Hui-Yun Cheng, Chih‐Hung Lin et autres

An innovative immunosuppressant with a minimally invasive delivery system has emerged in the biomedical field. The application of biodegradable and biocompatible polymer forms, such as hydrogels, scaffolds, microspheres, and nanoparticles, in transplant recipients to control the release of immunosuppressants can minimize the …

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