Zhuolun Song

P2.285: Hydrogel-based cytokine delivery accelerates liver regeneration following partial hepatectomy.

Catalina Ortiz, Zhuolun Song, Falak Babar, Hao Zhou et autres

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202.6: Aging attenuates humoral allosensitization through B cell-intrinsic alterations.

Friederike Martin, Zhuolun Song, Mukhammad Kaymunov, Yao Xiao et autres

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302.8: Defining the immune-metabolic landscape of aged allografts: Insights from metabolomic profiling in acute heart transplant rejection.

Sarah Tsou, Yuko Sato, Tatsuo Fukushima, Keita Nakamori et autres

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CIT-Bench1.0: Open-Source Benchmark Suite for Chiplet-based Advanced Packaging

Xiaokun Lin, Jixiang Zhu, Yujie Wang, Xiaoting Wang et autres

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The promise of organ rejuvenation to overcome the shortage in organ transplantation

Mukhammad Kayumov, Zhuolun Song, Friederike Martin, Sarah Tsou et autres

Organ shortage remains a major barrier in treating end-stage organ failure, with many patients dying while waiting or becoming medically unfit by the time an organ is offered. A substantial number of organs, particularly from older donors, remain unused due to concerns …

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Intestinal Epithelial Cell-derived Osteopontin Protects Against Metabolic Dysfunction–associated Steatohepatitis by Modulating Bile Acid Composition and the Gut Microbiome

Hui Han, Jeongwoo Park, Rui Zhang, Sukanta Das et autres

BACKGROUND & AIMS: The gut-liver axis plays a critical role in metabolic dysfunction-associated steatohepatitis (MASH). Osteopontin (OPN, encoded by SPP1) is implicated in chronic liver disease; however, its expression in intestinal epithelial cells (IECs) and role in MASH remain unclear. METHODS: ) …

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Kidney Disease as a Driver of Immunosenescence

Zhuolun Song, Sarah Tsou, Friederike Martin, Mukhammad Kayumov et autres

Immunosenescence, a state marked by immune dysfunction, chronic low-grade inflammation, and impaired pathogen defense, is accelerated in CKD. CKD promotes systemic inflammation through the accumulation of uremic toxins, oxidative stress, and dysregulated immune signaling, all driving premature aging of both innate and …

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Bone marrow mesenchymal stem cells alleviate liver fibrosis after rat liver transplantation through JAK1/STAT5 pathway

Zhuyuan Si, Shengqiao Zhao, Zhixin Zhang, Tianran Chen et autres

OBJECTIVE: The effectiveness of bone marrow mesenchymal stem cells (BMSCs) in post-transplantation liver fibrosis has not been studied. The aim of this study was to investigate the effect of BMSCs on liver fibrosis and their role in the Janus-activated kinase (JAK) 1/ …

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Abstract 7240: The role of myeloid cell derived HMGB1 in the development of hepatocellular carcinoma

Sai Santosh Babu Komakula, Xiaodong Ge, Wei Chen, Romain Désert et autres

Abstract Background: High mobility group box 1 (HMGB1) is a non-histone chromatin-associated protein involved in the pathogenesis of chronic liver disease. HMGB1 is expressed in myeloid cells, including conventional dendritic cells (cDCs), which play a major role in the tumor microenvironment. However, …

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Transplant oncology and anti-cancer immunosuppressants

Dejun Kong, Jinliang Duan, Zhenglu Wang, Jiashu Ren et autres

Organ transplantation is a life-saving intervention that enhances the quality of life for patients with end-stage organ failure. However, long-term immunosuppressive therapy is required to prevent allogeneic graft rejection, which inadvertently elevates the risk of post-transplant malignancies, especially for liver transplant recipients …

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Myosin Light Chain 9 Mediates Graft Fibrosis After Pediatric Liver Transplantation Through TLR4/MYD88/NF-κB Signaling

Zhixin Zhang, Chong Dong, Shengqiao Zhao, Zhuyuan Si et autres

BACKGROUND & AIMS: The incidence of graft fibrosis is elevated after pediatric liver transplantation (pLT) and is influenced by cold ischemic time (CIT). Myosin light chain 9 (MYL9), a member of the myosin family, could act on hepatic stellate cells (HSCs) and …

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Post-translational modifications drive the effects of HMGB1 in alcohol-associated liver disease

Xiaodong Ge, Nithyananthan Subramaniyam, Zhuolun Song, Romain Désert et autres

BACKGROUND: We previously identified that high-mobility group box-1 (HMGB1) is increased and undergoes post-translational modifications (PTMs) in response to alcohol consumption. Here, we hypothesized that specific PTMs, occurring mostly in hepatocytes and myeloid cells, could contribute to the pathogenesis of alcohol-associated liver …

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