Accès ouvert
2024
article
OpenAlex
Kazuteru Hasegawa, Yang Zhao, Alina Garbuzov, M. Ryan Corces et autres
Abstract Telomerase is intimately associated with stem cells and cancer, because it catalytically elongates telomeres—nucleoprotein caps that protect chromosome ends1. Overexpression of telomerase reverse transcriptase (TERT) enhances the proliferation of cells in a telomere-independent manner2–8, but so far, loss-of-function studies have provided …
us
(code pays fourni par la source)
Accès ouvert
2021
preprint
OpenAlex
Kazuteru Hasegawa, Yang Zhao, Alina Garbuzov, M. Ryan Corces et autres
Summary Telomerase is intimately associated with stem cells and upregulated in cancer, where it serves essential roles through its catalytic action in elongating telomeres, nucleoprotein caps that protect chromosome ends 1 . Overexpression of the telomerase reverse transcriptase (TERT) enhances cell proliferation …
us
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
Shengda Lin, Elisabete M. Nascimento, Chandresh R. Gajera, Lü Chen et autres
us
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
Alina Garbuzov, Matthew F. Pech, Kazuteru Hasegawa, Meena Sukhwani et autres
Undifferentiated spermatogonia comprise a pool of stem cells and progenitor cells that show heterogeneous expression of markers, including the cell surface receptor GFRα1. Technical challenges in isolation of GFRα1+ versus GFRα1- undifferentiated spermatogonia have precluded the comparative molecular characterization of these subpopulations …
us
(code pays fourni par la source)
2017
article
OpenAlex
Kazuteru Hasegawa, Alina Garbuzov, Shengda Lin, Matthew F. Pech et autres
Accès ouvert
2017
article
OpenAlex
Jonathan Kort, Alina Garbuzov, Julia Arand, Barry R. Behr et autres
us
(code pays fourni par la source)
Accès ouvert
2017
article
OpenAlex
Jonathan Kort, Alina Garbuzov, Steven E. Artandi, Barry Behr
us
(code pays fourni par la source)
2016
article
OpenAlex
Marisa M. Juntilla, Alina Garbuzov, Natalie Ortiz, Julia N. Eberhard et autres
Abstract Nucleophosmin 1 (NPM1) is the most common gene mutated in acute myeloid leukemia (AML). Several putative mechanisms for the role of NPM1 in the generation of AML have been proposed, including acting as a tumor suppressor by promoting the degradation of …
us
(code pays fourni par la source)
2016
article
OpenAlex
Kazuteru Hasegawa, Matthew F. Pech, Alina Garbuzov, Shengda Lin et autres
Accès ouvert
2015
preprint
OpenAlex
Matthew F. Pech, Alina Garbuzov, Kazuteru Hasegawa, Meena Sukhwani et autres
Telomerase inactivation causes loss of the male germline in worms, fish, and mice, indicating a conserved dependence on telomere maintenance in this cell lineage. Here, using telomerase reverse transcriptase (Tert) reporter mice, we found that very high telomerase expression is a hallmark …
us
(code pays fourni par la source)
2015
conference-abstract
OpenAlex
Matthew F. Pech, Alina Garbuzov, Meena Sukhwani, Bérénice Anath Benayoun et autres
Abstract One of the invariant features of human cancer is unlimited proliferation, a hallmark conferred by telomerase in 90% tumors. Somatic mutations in the telomerase reverse transcriptase (TERT) gene promoter are highly recurrent in human cancers. Telomerase is also critically important in …
us
(code pays fourni par la source)
Accès ouvert
2015
article
OpenAlex
Aparna Raval, Gregory K. Behbehani, Le Xuan Truong Nguyen, DANIEL W. THOMAS et autres
Telomere shortening is common in bone marrow failure syndromes such as dyskeratosis congenita (DC), aplastic anemia (AA) and myelodysplastic syndromes (MDS). However, improved knowledge of the lineage-specific consequences of telomere erosion and restoration of telomere length in hematopoietic progenitors is required to …
us, in
(code pays fourni par la source)