Paul C. Norris

CIeaD: A Complementary CID and EAD Mass Spectral Library for Phytochemicals

Yatendra Singh, Paul C. Norris, Sirapa Maharjan, Caroline Ferrante et autres

Plant metabolomics faces major challenges in metabolite identification due to the structural diversity of plant metabolites and limited coverage in existing spectral libraries. To address this, we developed CIeaD (Collision-Induced and Electron-Activated Dissociation), an open-access plant metabolite spectral library containing complementary CID …

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Author Correction: Piperideine-6-carboxylic acid regulates vitamin B6 homeostasis and modulates systemic immunity in plants

Huazhen Liu, Lakshminarayan M. Iyer, Paul C. Norris, Ruiying Liu et autres

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Piperideine-6-carboxylic acid regulates vitamin B6 homeostasis and modulates systemic immunity in plants

Huazhen Liu, Lakshminarayan M. Iyer, Paul C. Norris, Ruiying Liu et autres

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Is Lipid Metabolism of Value in Cancer Research and Treatment? Part I- Lipid Metabolism in Cancer

Ala F. Nassar, Xinxin Nie, Tianxiang Zhang, Jacky T. Yeung et autres

For either healthy or diseased organisms, lipids are key components for cellular membranes; they play important roles in numerous cellular processes including cell growth, proliferation, differentiation, energy storage and signaling. Exercise and disease development are examples of cellular environment alterations which produce …

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Is Lipid Metabolism of Value in Cancer Research and Treatment? Part II: Role of Specialized Pro-Resolving Mediators in Inflammation, Infections, and Cancer

Muhammad Usman Babar, Ala F. Nassar, Xinxin Nie, Tianxiang Zhang et autres

Acute inflammation is the body's first defense in response to pathogens or injury that is partially governed by a novel genus of endogenous lipid mediators that orchestrate the resolution of inflammation, coined specialized pro-resolving mediators (SPMs). SPMs, derived from omega-3-polyunstaturated fatty acids …

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Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity

Tianxiang Zhang, Weiwei Yu, Xiaoxiao Cheng, Jacky T. Yeung et autres

T cells are often absent from human cancer tissues during both spontaneously induced immunity and therapeutic immunotherapy, even in the presence of a functional T cell-recruiting chemokine system, suggesting the existence of T cell exclusion mechanisms that impair infiltration. Using a genome-wide …

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Author Correction: Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity

Oliver Werz, Jana Gerstmeier, Stephania Libreros, Xavier de la Rosa et autres

The original version of this Article contained an error in Fig. 1a, in which the two chromatograms for RvD2 and RvD5 were produced by re-plotting the raw LC–MS–MS output and omitting peaks considered of less relevance because there were no other prominent …

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Data Supplement from Targeted Deletion and Lipidomic Analysis Identify Epithelial Cell COX-2 as a Major Driver of Chemically Induced Skin Cancer

Jing Jiao, Tomo‐o Ishikawa, Darren S. Dumlao, Paul C. Norris et autres

Keratinocytes from Cox-2deltaE Cox-2flox/flox;K14Cre+) mice undergo effective targeted Cox-2 gene deletion. Keratinocyte were isolated from Cox-2deltaE and Cox-2flox/flox (Cox-2fl/fl) mice. Briefly, skin specimens isolated from 7-9 week old mice were treated with 3 mg/ml Dispase (Invitrogen, Carlsbad, CA) for 16 hrs at …

Data Supplement from Targeted Deletion and Lipidomic Analysis Identify Epithelial Cell COX-2 as a Major Driver of Chemically Induced Skin Cancer

Jing Jiao, Tomo‐o Ishikawa, Darren S. Dumlao, Paul C. Norris et autres

Epithelial thickness in response to short term DMBA/TPA treatment of Cox-2deltaE mice and their littermate Cox-2fl/fl mice (upper panels), and of Cox-2deltaM mice and their littermate Cox-2fl/fl mice (lower panels). Panels on the left show representative H&E skin sections, panels on the …

Data Supplement from Targeted Deletion and Lipidomic Analysis Identify Epithelial Cell COX-2 as a Major Driver of Chemically Induced Skin Cancer

Jing Jiao, Tomo‐o Ishikawa, Darren S. Dumlao, Paul C. Norris et autres

Skin and papilloma samples from Cox-2fl/fl and Cox-2deltaE littermate mice taken 18 hours after the last TPA treatment of the DMBA/TPA tumor induction protocol were immunostained for Cleaved-Caspase 3. Arrows indicate apoptotic cells.

Data Supplement from Targeted Deletion and Lipidomic Analysis Identify Epithelial Cell COX-2 as a Major Driver of Chemically Induced Skin Cancer

Jing Jiao, Tomo‐o Ishikawa, Darren S. Dumlao, Paul C. Norris et autres

Antibodies used for Immunohistochemistry analyses.

Data Supplement from Targeted Deletion and Lipidomic Analysis Identify Epithelial Cell COX-2 as a Major Driver of Chemically Induced Skin Cancer

Jing Jiao, Tomo‐o Ishikawa, Darren S. Dumlao, Paul C. Norris et autres

Papillomas developed on Cox-2deltaE mice have a significantly increased percentage of small vessels and a significantly decreased percentage of (medium-sized + large-sized) vessels when compared to papillomas from littermate control Cox-2fl/fl mice. Vessel size analysis was performed with the Definiens' Tissue Studio …