Noriko Nagi‐Miura

AIM2 targeting of nuclear DNA leakage in dendritic cells exacerbates vasculitis in a murine model of Kawasaki disease

Chintogtokh Baatarjav, Takanori Komada, Yoshitaka Gunji, Satoko Komori et autres

The AIM2 inflammasome in dendritic cells is a significant component of the murine model of Kawasaki disease-like vasculitis induced by CAWS injection. The AIM2 deficiency reduces vasculitis via reduced inflammatory cell infiltration and vascular fibrosis in CAWS-induced vasculitis. CAWS induces the damage …

jp (code pays fourni par la source)

Statin suppresses the development of excessive intimal proliferation in a Kawasaki disease mouse model

Yusuke Motoji, Ryuji Fukazawa, Ryosuke Matsui, Makoto Watanabe et autres

Kawasaki disease (KD) causes vascular injury and lifelong remodeling. Excessive intimal proliferation has been observed, resulting in coronary artery lesions (CALs). However, the mechanisms underlying vascular remodeling in CAL and statin treatment have not been comprehensively elucidated. This study aimed to investigate …

jp (code pays fourni par la source)

Candesartan Attenuates Vasculitis in a Mouse Model of Kawasaki Disease Induced by Candida albicans Water-Soluble Fraction

Ryosuke Matsui, Ryuji Fukazawa, Ryohei Fukunaga, Yusuke Motoji et autres

BACKGROUND: The standard treatment for Kawasaki disease is immunoglobulin therapy, but the high frequency of coronary sequelae in immunoglobulin-refractory cases indicates a need for further improvement in treatment. METHODS: Kawasaki disease-like vasculitis was induced in 5-week-old DBA/2 mice by intraperitoneal administration of …

jp (code pays fourni par la source)

Human Adipose Tissue-Derived Stem Cells Inhibit Coronary Artery Vasculitis in a Mouse Model of Kawasaki Disease

Ryohei Fukunaga, Takahiro Ueda, Ryosuke Matsui, Toshikazu Itabashi et autres

BACKGROUND: Adipose tissue-derived mesenchymal stem cells (ADSCs) are used for the treatment of various diseases because of their rapid proliferation and high anti-inflammatory and tissue repair properties. Kawasaki disease is a systemic vasculitis with coronary arteritis and aneurysms occurring in pediatric patients. …

jp (code pays fourni par la source)

Statins Show Anti-Atherosclerotic Effects by Improving Endothelial Cell Function in a Kawasaki Disease-like Vasculitis Mouse Model

Yusuke Motoji, Ryuji Fukazawa, Ryosuke Matsui, Yoshinori Abe et autres

Kawasaki disease (KD) is an acute inflammatory syndrome of unknown etiology that is complicated by cardiovascular sequelae. Chronic inflammation (vasculitis) due to KD might cause vascular cellular senescence and vascular endothelial cell damage, and is a potential cause of atherosclerosis in young …

jp (code pays fourni par la source)

Kawasaki Disease-like Vasculitis Facilitates Atherosclerosis, and Statin Shows a Significant Antiatherosclerosis and Anti-Inflammatory Effect in a Kawasaki Disease Model Mouse

Yusuke Motoji, Ryuji Fukazawa, Ryosuke Matsui, Noriko Nagi‐Miura et autres

Kawasaki disease (KD) is an acute form of systemic vasculitis that may promote atherosclerosis in adulthood. This study examined the relationships between KD, atherosclerosis, and the long-term effects of HMG-CoA inhibitors (statins). Candida albicans water-soluble fraction (CAWS) was injected intraperitoneally into 5-week-old …

jp (code pays fourni par la source)

Sivelestat's effect on Candida albicans water‐soluble fraction‐induced vasculitis

Yuya Yoshida, Rie Banno‐Terada, Masashi Takada, Toui Fujii et autres

BACKGROUND: We investigated the efficacy of sivelestat sodium hydrate (SSH) as a treatment for Kawasaki disease, and its pharmacological action sites, in mice with Candida albicans water-soluble fraction-induced vasculitis. METHODS: Sivelestat sodium hydrate was administered intraperitoneally to Candida albicans water-soluble fraction-induced vasculitis …

jp (code pays fourni par la source)

Recombinant Human Soluble Thrombomodulin Suppresses Arteritis in a Mouse Model of Kawasaki Disease

Hironobu Nakayama, Hiroyasu Inada, Tatsuya Inukai, Kenta Kondo et autres

INTRODUCTION AND OBJECTIVE: Kawasaki disease (KD) is associated with diffuse and systemic vasculitis of unknown aetiology and primarily affects infants and children. Intravenous immunoglobulin (IVIG) treatment reduces the risk of developing coronary aneurysms, but some children have IVIG-resistant KD, which increases their …

jp (code pays fourni par la source)

Recombinant Human Soluble Thrombomodulin Suppresses Arteritis in a Mouse Model of Kawasaki Disease

Hironobu Nakayama, Hiroyasu Inada, Tatsuya Inukai, Kenta Kondo et autres

jp (code pays fourni par la source)

Supplementary Material for: Recombinant Human Soluble Thrombomodulin Suppresses Arteritis in a Mouse Model of Kawasaki Disease

Hironobu Nakayama, Hiroyasu Inada, Toshihiko Inukai, Kenta Kondo et autres

Introduction and Objective: Kawasaki disease (KD) is associated with diffuse and systemic vasculitis of unknown aetiology and primarily affects infants and children. Intravenous immunoglobulin (IVIG) treatment reduces the risk of developing coronary aneurysms, but some children have IVIG-resistant KD, which increases their …

Crucial role of NLRP3 inflammasome in a murine model of Kawasaki disease

Fumiya Anzai, Sachiko Watanabe, Hiroaki J. Kimura, Ryo Kamata et autres

jp (code pays fourni par la source)

Adipose tissue‐derived stem cells suppress coronary arteritis of Kawasaki disease in vivo

Ryoichi Uchimura, Takahiro Ueda, Ryuji Fukazawa, Jun Hayakawa et autres

BACKGROUND: Kawasaki disease (KD) is a systemic inflammatory disease resulting in an acute febrile syndrome commonly affecting children younger than 5 years. Coronary arteritis in KD is occasionally non-responsive to several treatments. Recently, adipose tissue-derived stem cells (ADSCs) have been shown to …

jp (code pays fourni par la source)