Hiroyasu Inada

Recombinant Human Soluble Thrombomodulin Suppresses Arteritis in a Mouse Model of Kawasaki Disease

Hironobu Nakayama, Hiroyasu Inada, Tatsuya Inukai, Kenta Kondo et autres

INTRODUCTION AND OBJECTIVE: Kawasaki disease (KD) is associated with diffuse and systemic vasculitis of unknown aetiology and primarily affects infants and children. Intravenous immunoglobulin (IVIG) treatment reduces the risk of developing coronary aneurysms, but some children have IVIG-resistant KD, which increases their …

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Recombinant Human Soluble Thrombomodulin Suppresses Arteritis in a Mouse Model of Kawasaki Disease

Hironobu Nakayama, Hiroyasu Inada, Tatsuya Inukai, Kenta Kondo et autres

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Supplementary Material for: Recombinant Human Soluble Thrombomodulin Suppresses Arteritis in a Mouse Model of Kawasaki Disease

Hironobu Nakayama, Hiroyasu Inada, Toshihiko Inukai, Kenta Kondo et autres

Introduction and Objective: Kawasaki disease (KD) is associated with diffuse and systemic vasculitis of unknown aetiology and primarily affects infants and children. Intravenous immunoglobulin (IVIG) treatment reduces the risk of developing coronary aneurysms, but some children have IVIG-resistant KD, which increases their …

SOCS1 Antagonist–Expressing Recombinant Bacillus Calmette–Guérin Enhances Antituberculosis Protection in a Mouse Model

Satoru Mizuno, Shogo Soma, Hiroyasu Inada, Tomohiro Kanuma et autres

Abstract Suppressor of cytokine signaling 1 (SOCS1) plays a key role in the negative regulation of JAK/STAT signaling, which is involved in innate immunity and subsequent adaptive immunity. Bacillus Calmette–Guérin (BCG) induces upregulation of SOCS1 expression in host cells, which may lead …

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Primary Role of Suppressor of Cytokine Signaling 1 in Mycobacterium bovis BCG Infection

Shogo Soma, Satoru Kawai, Hiroyasu Inada, Kenta Watanabe et autres

Suppressor of cytokine signaling 1 (SOCS1) is a negative regulator of JAK/STAT signaling and is induced by mycobacterial infection. To understand the major function of SOCS1 during infection, we established a novel system in which recombinant Mycobacterium bovis bacillus Calmette-Guérin expressed dominant-negative …

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Restrictive IL-10 induction by an innocuous parainfluenza virus vector ameliorates nasal allergy

Keiichi Yamanaka, Takehisa Nakanishi, Kana Isono, Chisami Hasegawa et autres

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Effects of Mycobacteria Major Secretion Protein, Ag85B, on Allergic Inflammation in the Lung

Yusuke Tsujimura, Hiroyasu Inada, Misao Yoneda, Tomoyuki Fujita et autres

Many epidemiological studies have suggested that the recent increase in prevalence and severity of allergic diseases such as asthma is inversely correlated with Mycobacterium bovis bacillus Calmette Guerin (BCG) vaccination. However, the underlying mechanisms by which mycobacterial components suppress allergic diseases are …

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Recombinant Ag85B vaccine by taking advantage of characteristics of human parainfluenza type 2 virus vector showed Mycobacteria-specific immune responses by intranasal immunization

Kenta Watanabe, Akihiro Matsubara, Mitsuo Kawano, Satoru Mizuno et autres

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Intranasally Administered Antigen 85B Gene Vaccine in Non-Replicating Human Parainfluenza Type 2 Virus Vector Ameliorates Mouse Atopic Dermatitis

Hiroshi Kitagawa, Mitsuo Kawano, Keiichi Yamanaka, Masato Kakeda et autres

Atopic dermatitis (AD) is a refractory and recurrent inflammatory skin disease. Various factors including heredity, environmental agent, innate and acquired immunity, and skin barrier function participate in the pathogenesis of AD. T -helper (Th) 2-dominant immunological milieu has been suggested in the …

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Cynomolgus monkey induced pluripotent stem cells established by using exogenous genes derived from the same monkey species

Nobuhiro Shimozawa, Ryoichi Ono, Manami Shimada, Hiroaki Shibata et autres

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A case of pancreatic ductal adenocarcinoma with marked infiltration with IgG4-positive cells

Misao Yoneda, Hiroyasu Inada, Kazuki Kanayama, Tadashi Shiraishi

A 75-year-old man was diagnosed as having pancreatic ductal carcinoma containing remarkable lymphocytic and plasma cell infiltration, as revealed by the cytological examination of endoscopic ultrasound guided fine-needle aspiration (EUS-FNA) specimen. The EUS-FNA specimen showed small amounts of atypical epithelium with noticeable …

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Single systemic administration of Ag85B of mycobacteria DNA inhibits allergic airway inflammation in a mouse model of asthma

K Karamatsu, K Matsuo, Hiroyasu Inada, Y Tsujimura et autres

Katsuo Karamatsu,1,2 Kazuhiro Matsuo,3 Hiroyasu Inada,4 Yusuke Tsujimura,1 Yumiko Shiogama,1,2 Akihiro Matsubara,1,2 Mitsuo Kawano,5 Yasuhiro Yasutomi1,21Laboratory of Immunoregulation and Vaccine Research, Tsukuba Primate Research Center, National Institute of Biomedical Innovation, Tsukuba, 2Division of Immunoregulation, Department of Molecular and Experimental Medicine, Mie University …