Emna Harigua‐Souiai

Adjusted imbalance ratio leads to effective AI-based drug discovery against infectious disease

Ons Masmoudi, Afef Abdelkrim, Emna Harigua‐Souiai

The success of AI-based pipelines in Drug Discovery (DD) heavily depends on three components: the dataset (size, content, imbalance ratio), the encoding system and the predictive model. This study focuses on optimizing these elements to develop robust predictive models for the biological …

Tunisie (code pays fourni par la source)

Emergence and evolution of epizootic hemorrhagic disease virus in the Mediterranean region: spatio-temporal dynamics and epidemiological insights

Marwa Arbi, Emna Harigua‐Souiai, Mariem Hanachi, Imen Larbi et autres

Background: Epizootic Hemorrhagic Disease Virus (EHDV) is an arbovirus, transmitted to wild and domestic ruminants through Culicoides biting midges. Since 2006, high morbidity and mortality cases of EHDV have been reported among cattle and deer populations in several Mediterranean countries. The temporal …

Tunisie (code pays fourni par la source)

Lesionia: a digital data management system to enhance collaborative management of epidemiological and clinical data of cutaneous leishmaniases patients

Emna Harigua‐Souiai, Youssef Ben Salem, Maaoui Hariga, Yusr Saadi Ben Aoun et autres

Digital Systems for Data Management (DSDM) have become a critical cornerstone in collaborative biomedical research and clinical trials involving multiple investigators, institutions, and populations. DSDM provide unique features that ensure that data meet the standards of FAIR (Findability, Accessibility, Interoperability and Reusability). …

Tunisie, Nigéria, Maroc, lb (code pays fourni par la source)

Recombinase-based amplification coupled with lateral flow chromatography for the specific and sensitive detection and identification of Leishmania major in cutaneous leishmaniasis patients

Insaf Bel Hadj Ali, Yusr Saadi Ben Aoun, Imen Khammeri, Hejer Souguir et autres

Introduction Cutaneous leishmaniases (CL), a wide range of cutaneous diseases caused by diverse species of Leishmania genus parasites, are among the most neglected infectious diseases. While they are non-fatal, CL are highly morbid with disfiguring lesions, which could be chronic, leaving lifelong …

Tunisie, Maroc, lb, us (code pays fourni par la source)

cidalsDB: an AI-empowered platform for anti-pathogen therapeutics research

Emna Harigua‐Souiai, Ons Masmoudi, Samer Makni, Rafeh Oualha et autres

Computer-aided drug discovery (CADD) is nurtured by late advances in big data analytics and Artificial Intelligence (AI) towards enhanced drug discovery (DD) outcomes. In this context, reliable datasets are of utmost importance. We herein present CidalsDB a novel web server for AI-assisted …

Tunisie (code pays fourni par la source)

Using machine learning to explore the genetics of tobacco addiction: A study of an African American population

Ibrahima Diallo, Ines Abdeljaoued-Tej, Emna Harigua‐Souiai, Christian Happi et autres

The World Health Organization estimates that smoking-related lung cancer account for more than 7 million deaths worldwide each year. Cigarette smoking is also a risk factor for various health issues including respiratory as well as other infections, osteoporosis, reproductive disorders, adverse postoperative …

us, Tunisie, Nigéria (code pays fourni par la source)

Approved drugs successfully repurposed against Leishmania based on machine learning predictions

Rafeh Oualha, Yosser Zina Abdelkrim, Ikram Guizani, Emna Harigua‐Souiai

Drug repurposing is a promising approach towards the discovery of novel treatments against Neglected Tropical Diseases, such as Leishmaniases, presenting the advantage of reducing both costs and duration of the drug discovery process. In previous work, our group developed a Machine Learning …

Tunisie (code pays fourni par la source)

Exploring AI governance in the Middle East and North Africa (MENA) region: gaps, efforts, and initiatives

Hana Trigui, Fatma Z. Guerfali, Emna Harigua‐Souiai, Radwan Qasrawi et autres

Abstract This commentary explores MENA”s AI governance, addressing gaps, showcasing successful strategies, and comparing national approaches. It emphasizes current deficiencies, highlights regional contributions to global AI governance, and offers insights into effective frameworks. The study reveals distinctions and trends in MENA”s national …

us, Tunisie, ps, tr, lb, ca (code pays fourni par la source)

Pathologic complete response to neoadjuvant imatinib of a gastric stromal tumor with concomitant mutations in KIT : A case report and literature review

Mariem Ben Rekaya, Feryel Letaief Ksontini, Linda Bel Haj Kacem, Farah Sassi et autres

Key clinical message We report the first case of pathologic complete response (pCR) to neoadjuvant imatinib in a gastric stromal tumor harboring KIT mutations in both exons 11 and 9. The significance of this co‐occurrence is unknown and might increase the responsiveness …

Tunisie (code pays fourni par la source)

ANTIPSEUDOBASE: Database of Antimicrobial Peptides and Essential Oils Against Pseudomonas

Abdelmajid Zouhir, Oussama Souiaï, Emna Harigua‐Souiai, Ammar Cherif et autres

Tunisie, sa (code pays fourni par la source)

Retrospective Phylodynamic and Phylogeographic Analysis of the Bluetongue Virus in Tunisia

Oussema Souiai, Marwa Arbi, Mariem Hanachi, Ameny Sallami et autres

Bluetongue virus (BTV) is an arbovirus considered as a major threat for the global livestock economy. Since 1999, Tunisia has experienced several incursions of BTV, during which numerous cases of infection and mortality have been reported. However, the geographical origin and epidemiological …

Tunisie (code pays fourni par la source)

Enzymatic and Molecular Characterization of Anti-Leishmania Molecules That Differently Target Leishmania and Mammalian eIF4A Proteins, LieIF4A and eIF4AMus

Yosser Zina Abdelkrim, Emna Harigua‐Souiai, Imen Bassoumi-Jamoussi, Mourad Barhoumi et autres

Previous investigations of the Leishmania infantum eIF4A-like protein (LieIF4A) as a potential drug target delivered cholestanol derivatives inhibitors. Here, we investigated the mode of action of cholesterol derivatives as a novel scaffold structure of LieIF4A inhibitors on the RNA-dependent ATPase activity of …

Tunisie, fr (code pays fourni par la source)