Mourad Barhoumi

Leishmania infantum eukaryotic initiation factor 4A modulates in vitro functional activity of human neutrophils

Rafeh Oualha, Yosser Zina Abdelkrim, Mourad Barhoumi, Sonia Ben Hamouda et autres

Leishmaniases are a group of neglected tropical diseases caused by Leishmania parasites which virulence mainly relies on its modulation of the host immune response. Neutrophils, the first recruited innate immune cells at the site of infection, are key determinants of the early …

Tunisie (code pays fourni par la source)

Identification and characterization of a PRP5 / DDX46 ‐like DEAD ‐box helicase with noncanonical calcium‐dependent enzymatic activity from the trypanosomatid parasite Leishmania infantum

Yosser Zina Abdelkrim, Molka Mokdadi, Josette Banroques, Emmeline Huvelle et autres

The DEAD-box proteins of the superfamily II (SF2) RNA/DNA helicases are typically found to be ATP-dependent RNA binding proteins and RNA-dependent ATPases; however, they have poor, nonprocessive, RNA unwinding activity. Moreover, cells contain multiple variants that are associated with specific cellular processes, …

fr, Tunisie (code pays fourni par la source)

The ecoepidemiology of cutaneous leishmaniasis in Ethiopia: a systematic review and meta-analysis

Galana Mamo Ayana, Derese Bekele Daba, Bedilu Alamirie Ejigu, Debisa Eshatu Wendimu et autres

BACKGROUND: Cutaneous leishmaniasis (CL) is a neglected tropical skin disease. In Ethiopia, CL is a public health concern; about 29 million people are at risk, with an estimated incidence of up to 50,000 new cases annually. In endemic communities, access to diagnosis, …

Éthiopie, Tunisie, pk, es (code pays fourni par la source)

Extensive heterozygosity and genetic exchange among natural populations of Leishmania species

Eliza V. C. Alves-Ferreira, Mourad Barhoumi, Tiago Rodrigues Ferreira, Matthew W. Brown et autres

Genetic hybridization within the genus Leishmania has been demonstrated experimentally, but the extent to which this occurs naturally among circulating populations remains enigmatic. The current consensus is that natural populations undergo preponderant clonal evolution, presumably expanding by asexual replication. To investigate the …

us, Tunisie, cz, Algérie (code pays fourni par la source)

Repurposing approved drugs targeting Leishmania infantum 5-Methylthioadenosine Phosphorylase as anti-leishmanial candidates

Yosser Zina Abdelkrim, Rafeh Oualha, Sonia Abbes, Isleme Khalfaoui et autres

Introduction Drug repurposing is a promising strategy for identifying new treatments against neglected tropical diseases such as leishmaniases, which are endemic in Asia, Africa, the Americas, and Southern Europe, offering the advantages of reduced development time and cost. In this context, computational …

Tunisie (code pays fourni par la source)

Leishmania infantum eukaryotic initiation factor 4A modulates in vitro functional activity of human neutrophils.

Rafeh Oualha, Yosser Zina Abdelkrim, Mourad Barhoumi, Sonia Ben Hamouda et autres

Eukaryotic Initiation Factor 4A (LieIF), an excreted/secreted protein, on human neutrophils. Stimulation with recombinant LieIF protein induced a strong pro-inflammatory neutrophil response characterized by increased ROS production, degranulation, late apoptosis and enhanced secretion of IL-8, TNF-α, IL-1β and IL-6 cytokines associated with …

Tunisie (code pays fourni par la source)

Genetic Diversity and Population Structure of Leishmania infantum in Morocco as Revealed by Multilocus Sequence Typing (MLST) Approach

Sara El Mazini, Mourad Barhoumi, Idris Mhaidi, Othmane Daoui et autres

Leishmania infantum is endemic in Morocco, and it causes both visceral (VL) and cutaneous leishmaniasis (CL). In this study, the multilocus sequence typing (MLST) approach was used to investigate the phylogeny and population structure of Leishmania infantum strains isolated from CL and …

Maroc, Tunisie (code pays fourni par la source)

Enzymatic and Molecular Characterization of Anti-Leishmania Molecules That Differently Target Leishmania and Mammalian eIF4A Proteins, LieIF4A and eIF4AMus

Yosser Zina Abdelkrim, Emna Harigua‐Souiai, Imen Bassoumi-Jamoussi, Mourad Barhoumi et autres

Previous investigations of the Leishmania infantum eIF4A-like protein (LieIF4A) as a potential drug target delivered cholestanol derivatives inhibitors. Here, we investigated the mode of action of cholesterol derivatives as a novel scaffold structure of LieIF4A inhibitors on the RNA-dependent ATPase activity of …

Tunisie, fr (code pays fourni par la source)

Multilocus sequence analysis provides new insight into population structure and genetic diversity of Leishmania tropica in Morocco

Sofia El Kacem, Mouad Ait Kbaich, Othmane Daoui, Hicham Charoute et autres

Maroc, Tunisie (code pays fourni par la source)

The In Silico Identification of Potential Members of the Ded1/DDX3 Subfamily of DEAD-Box RNA Helicases from the Protozoan Parasite Leishmania infantum and Their Analyses in Yeast

Molka Mokdadi, Yosser Zina Abdelkrim, Josette Banroques, Emmeline Huvelle et autres

DEAD-box RNA helicases are ubiquitous proteins found in all kingdoms of life and that are associated with all processes involving RNA. Their central roles in biology make these proteins potential targets for therapeutic or prophylactic drugs. The Ded1/DDX3 subfamily of DEAD-box proteins …

Tunisie, fr (code pays fourni par la source)

New Insights on the Adjuvant Properties of the Leishmania Infantum Eukaryotic Initiation Factor

Olga S. Koutsoni, Mourad Barhoumi, Ikram Guizani, Eleni Dotsika

Vaccination is the most effective tool against infectious diseases.Subunit vaccines are safer compared to live-attenuated vaccines but are less immunogenic and need to be delivered with an adjuvant.Adjuvants are essential for enhancing vaccine potency by improving humoral and cell-mediated immune responses.Only a …

gr, Tunisie (code pays fourni par la source)

Infection of Human Neutrophils With Leishmania infantum or Leishmania major Strains Triggers Activation and Differential Cytokines Release

Rafeh Oualha, Mourad Barhoumi, Soumaya Marzouki, Emna Harigua‐Souiai et autres

Leishmaniases are neglected diseases, caused by intracellular protozoan parasites of the Leishmania (L.) genus. Although the principal host cells of the parasites are macrophages, neutrophils are the first cells rapidly recruited to the site of parasites inoculation, where they play an important …

Tunisie (code pays fourni par la source)