Lorenzo Turcano

Cyclic Peptide Inhibitors of the MLH1-MSH3 Interaction as a Potential Therapeutic Strategy for Huntington's Disease

Tasir S. Haque, Federica Orvieto, Sara Tomaselli, Lorenzo Turcano et autres

Components of the DNA mismatch repair (MMR) pathway modulate somatic CAG-repeat expansion at the huntingtin (HTT) locus and alter the age of clinical motor diagnosis and progression of Huntington's disease (HD). MSH3, which encodes a subunit of MutSβ (MSH2-MSH3), has been identified …

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Cyclic Peptide Inhibitors of the MLH1-MSH3 Interaction as a Potential Therapeutic Strategy for Huntington's Disease

Tasir S. Haque, Federica Orvieto, Sara Tomaselli, Lorenzo Turcano et autres

Components of the DNA mismatch repair (MMR) pathway modulate somatic CAG-repeat expansion at the huntingtin (HTT) locus and alter the age of clinical motor diagnosis and progression of Huntington's disease (HD). MSH3, which encodes a subunit of MutSβ (MSH2-MSH3), has been identified …

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Identification and in vitro characterization of a new series of potent and highly selective G9a inhibitors as novel anti-fibroadipogenic agents

Pietro Randazzo, Roberta Sinisi, Davide Gornati, Stefania Bertuolo et autres

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Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme

Lorenzo Turcano, Theo Battista, Esther Torrente De Haro, Antonino Missineo et autres

Trypanothione reductase (TR) is a key enzyme that catalyzes the reduction of trypanothione, an antioxidant dithiol that protects Trypanosomatid parasites from oxidative stress induced by mammalian host defense systems. TR is considered an attractive target for the development of novel anti-parasitic agents …

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Discovery and Preliminary Characterization of Translational Modulators that Impair the Binding of eIF6 to 60S Ribosomal Subunits

Elisa Pesce, Annarita Miluzio, Lorenzo Turcano, Claudia Minici et autres

Eukaryotic initiation factor 6 (eIF6) is necessary for the nucleolar biogenesis of 60S ribosomes. However, most of eIF6 resides in the cytoplasm, where it acts as an initiation factor. eIF6 is necessary for maximal protein synthesis downstream of growth factor stimulation. eIF6 …

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Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening

Lorenzo Turcano, Esther Torrente, Antonino Missineo, Matteo Andreini et autres

Trypanothione reductase (TR) is considered to be one of the best targets to find new drugs against Leishmaniasis.This enzyme is fundamental for parasite survival in the host since it reduces trypanothione, a molecule used by the tryparedoxin/tryparedoxin peroxidase system of Leishmania to …

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Identification by High-Throughput Screening of Pseudomonas Acyl–Coenzyme A Synthetase Inhibitors

Lorenzo Turcano, Daniela Visaggio, Emanuela Frangipani, Antonino Missineo et autres

Pseudomonas infections are common among hospitalized, immunocompromised, and chronic lung disease patients. These infections are recalcitrant to common antibacterial therapies due to inherent antibiotic resistance. To meet the need of new anti- Pseudomonas drugs, a sensitive, homogenous, and robust assay was developed …

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Aloe-emodin exerts a potent anticancer and immunomodulatory activity on BRAF-mutated human melanoma cells

Claudio Tabolacci, Martina Cordella, Lorenzo Turcano, Stefania Rossi et autres

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Aloin enhances cisplatin antineoplastic activity in B16-F10 melanoma cells by transglutaminase-induced differentiation

Claudio Tabolacci, Stefania Rossi, Alessandro Lentini, Bruno Provenzano et autres

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