Accès ouvert
2021
article
OpenAlex
Wataru Matsunaga, Katsuyuki Hamada, Masatoshi Tagawa, Takao Morinaga et autres
BACKGROUND: The clustered regularly interspaced short palindromic repeats-associated protein 9 (CRISPR-Cas9) is thought to have promising clinical potential. However, the off-target effects of Cas9 are a major concern for its application. Therefore, we hypothesized that the adverse effects of off-target gene editing …
jp
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Accès ouvert
2021
article
OpenAlex
Tomoko Ito, Kikuya Sugiura, Aya Hasegawa, Wakana Ouchi et autres
Tumor-derived extracellular vesicles (EVs), as tumor vaccines, carry tumor-associated antigens (TAAs), and were expected to transfer TAAs to antigen-presenting cells. However, treatment with tumor-derived EVs exhibited no obvious antitumor effect on the established tumors, likely due to their immuno-suppressive functions, and also …
jp
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Accès ouvert
2018
article
OpenAlex
Katsuyuki Hamada, Soichi Takagi, Hajime Kuboshima, Hideaki Shimada et autres
BACKGROUND: A549 carrier cells infected with oncolytic adenovirus can induce complete tumor reduction of subcutaneous ovarian tumors but not intraperitoneal disseminated ovarian tumors. This appears to be a result of the insufficient antitumor effect of A549 carrier cells. Therefore, in the present …
jp, us
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Accès ouvert
2017
article
OpenAlex
Toshiaki Yasuoka, Toru Fujioka, Megumi Ueno, Sakiko Murakami et autres
BACKGROUND: With the increase in the cesarean section rate, the complications associated with cesarean section wounds have also increased. The presence of a cesarean scar defect and diverticulum has recently been identified as a source of persistent, irregular vaginal bleeding, menstrual pain, …
jp
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Accès ouvert
2016
article
OpenAlex
Nozomi Saito, Iman Abdullah, Kayoko Hayashi, Katsuyuki Hamada et autres
We succeeded in the development of a new method for enantioselective synthesis of alpha-substituted-beta-amino acid derivatives. Thus, nickel(0)-promoted carboxylation of ynamide gave the alpha-substituted-beta-aminoacrylate derivative in a highly regioselective manner. Then, rhodium-catalyzed asymmetric hydrogenation of the a-substituted beta-aminoacrylate produced the corresponding alpha-substituted …
jp
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Accès ouvert
2016
article
OpenAlex
Katsuyuki Hamada, Kazuko Takagi, Takashi Sugiyama
Infection inhibition of virus by antiviral antibodies is one of the major problems that cancer gene therapy has never shown the significant antitumor activity in human clinical trial. Oncolytic adenovirus-infected A549 carrier cells develop cell fragments and exosomes containing oncolytic adenoviral particles …
jp
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Accès ouvert
2016
article
OpenAlex
Keiichi Matsubara, Yuko Matsubara, Miki Mori, Yuka Uchikura et autres
The CD40 ligand (CD40L) is expressed by T cells and has a critical role in immune system regulation. Interventions targeting CD40L interactions following embryo implantation represent an approach to preventing preeclampsia (PE). To better understand the role of CD40L in PE, we …
jp
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Accès ouvert
2016
article
OpenAlex
Kaname Nosaki, Katsuyuki Hamada, Yuto Takashima, Miyako Sagara et autres
Although various therapies are available to treat cancers, including surgery, chemotherapy, and radiotherapy, cancer has been the leading cause of death in Japan for the last 30 years, and new therapeutic modalities are urgently needed. As a new modality, there has recently …
jp
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Accès ouvert
2015
article
OpenAlex
Katsuyuki Hamada, Kazuko Takagi, Hiroshi Itoh, Kenzaburo Tani et autres
Although replication-competent viruses have been developed to treat cancers, their cytotoxic effects are insufficient, since infection with them is inhibited by generation of neutralizing antibodies. To address this limitation, we developed a carrier cell system to deliver a replication-competent adenovirus. Carrier cells …
jp
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Accès ouvert
2015
article
OpenAlex
Kaname Nosaki, Katsuyuki Hamada, Yuto Takishima, Miyako Sagara et autres
Background: Although there have recently been much progress in cancer treatment including surgery, chemotherapy and radiotherapy, cancers have long been the leading cause of death in Japan in the last 30 years and the development of new therapeutic modalities is imminently required. …
jp
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Accès ouvert
2014
article
OpenAlex
Katsuyuki Hamada, Toshiro Shirakawa, Shuji Terao, Akinobu Gotoh et autres
The use of carrier cells infected with oncolytic viruses in cancer gene therapy is an attractive method because it can overcome viral immunogenicity and induce tumor immunity and significant antitumor activity. To enable human clinical trials of this treatment, acute and chronic …
jp, cn
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Accès ouvert
2013
article
OpenAlex
Toshiaki Yasuoka, Hisashi Hashimoto, Katsuyuki Hamada, Toru Fujioka et autres
•We herein report a case of a 44-year-old Japanese woman diagnosed with stage IB1 atypical carcinoid of the uterine cervix.•After radical hysterectomy, she developed recurrence with aggressive clinical behavior, resistance to CPT-11 + cisplatin and paclitaxel + CBDCA chemotherapy.
jp
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